MICA
MICA(MHC类I链相关蛋白A)是位于人类MHC区域的非经典MHC I类分子,具有高度多态性。它编码一个含有3个α螺旋的跨膜蛋白,其结构与经典MHC I类分子相似但存在关键差异。MICA的主要功能是作为应激诱导分子在多种上皮肿瘤细胞表面表达,并激活通过与NKG2D受体结合的免疫细胞,如NK细胞、NKT细胞、γδT细胞和CD8+T细胞,介导这些细胞的活化并杀伤靶细胞。MICA参与的信号通路主要是NKG2D信号通路,它通过与NKG2D受体的相互作用触发免疫细胞的细胞毒性程序和共刺激信号通路,对肿瘤细胞逃脱机体免疫监视过程中发挥主要作用。肿瘤细胞可能通过蛋白水解使细胞表面MICA脱落来逃避免疫识别。MICA的功能性结构域为胞外的α1和α2结构域,这些结构域对免疫细胞的识别和激活至关重要。MICA的表达和功能对于维持机体对肿瘤的免疫监视非常重要,其异常表达或功能失调与多种肿瘤的发生发展有关。MICA的研究有助于开发新的癌症治疗策略,尤其是在利用免疫系统对抗肿瘤方面显示出重要性。
热销产品
MICA Recombinant Monoclonal Antibody (CSB-RA574653A0HU)
验证数据
IHC image of CSB-RA574653A0HU diluted at 1:80 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.49% DAB.
IHC image of CSB-RA574653A0HU diluted at 1:80 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.49% DAB.
MICA Antibodies
MICA for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA013806GA01HU | MICA Antibody | Human | ELISA,WB |
CSB-PA013806ESR2HU | MICA Antibody | Human | ELISA, IHC |
CSB-PA013806ESR1HU | MICA Antibody | Human, Mouse | ELISA, WB, IHC |
CSB-RA574653A0HU | MICA Recombinant Monoclonal Antibody | Human | ELISA, IHC |
MICA Proteins
MICA Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP013806HU CSB-EP013806HU CSB-BP013806HU CSB-MP013806HU CSB-EP013806HU-B |
Recombinant Human MHC class I polypeptide-related sequence A (MICA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP000251HU | Recombinant Human MHC class I polypeptide-related sequence A protein (MICA) | E.Coli |
CSB-AP000261HU | Recombinant Human MHC class I polypeptide-related sequence A protein (MICA) | E.Coli |
CSB-AP005551HU | Recombinant Human MHC class I polypeptide-related sequence A (MICA), partial (Active) | Mammalian cell |
MICA ELISA Kit
MICA ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-E13782h | Human major histocompatibility complex class I chain-related gene A (MICA) ELISA Kit | serum, plasma, tissue homogenates | 0.39 ng/mL |