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MICA

MICA(MHC类I链相关蛋白A)是位于人类MHC区域的非经典MHC I类分子,具有高度多态性。它编码一个含有3个α螺旋的跨膜蛋白,其结构与经典MHC I类分子相似但存在关键差异。MICA的主要功能是作为应激诱导分子在多种上皮肿瘤细胞表面表达,并激活通过与NKG2D受体结合的免疫细胞,如NK细胞、NKT细胞、γδT细胞和CD8+T细胞,介导这些细胞的活化并杀伤靶细胞。MICA参与的信号通路主要是NKG2D信号通路,它通过与NKG2D受体的相互作用触发免疫细胞的细胞毒性程序和共刺激信号通路,对肿瘤细胞逃脱机体免疫监视过程中发挥主要作用。肿瘤细胞可能通过蛋白水解使细胞表面MICA脱落来逃避免疫识别。MICA的功能性结构域为胞外的α1和α2结构域,这些结构域对免疫细胞的识别和激活至关重要。MICA的表达和功能对于维持机体对肿瘤的免疫监视非常重要,其异常表达或功能失调与多种肿瘤的发生发展有关。MICA的研究有助于开发新的癌症治疗策略,尤其是在利用免疫系统对抗肿瘤方面显示出重要性。

热销产品

MICA Recombinant Monoclonal Antibody (CSB-RA574653A0HU)

验证数据

CSB-RA574653A0HU

IHC image of CSB-RA574653A0HU diluted at 1:80 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.49% DAB.

CSB-RA574653A0HU

IHC image of CSB-RA574653A0HU diluted at 1:80 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.49% DAB.

MICA Antibodies

MICA for Homo sapiens (Human)

MICA Proteins

MICA Proteins for Homo sapiens (Human)

MICA ELISA Kit

MICA ELISA Kit for Homo sapiens (Human)