MAT2A
MAT2A，即甲硫氨酸腺苷转移酶2A，别名AdoMet合成酶2、Methionine adenosyltransferase 2、S-adenosylmethionine synthase isoform type-2等。它是一种在人体内催化甲硫氨酸转化为S-腺苷甲硫氨酸（SAM）的关键酶，SAM是细胞内最重要的甲基供体，参与多种生物分子的甲基化过程。MAT2A由人体细胞自身的基因编码，在多种组织中都有表达，尤其在睾丸组织中表达量较高。其作用机制涉及到将ATP和甲硫氨酸作为底物，通过转移磷酸腺苷基团至甲硫氨酸，生成SAM，这一过程对维持细胞内的甲基化水平至关重要。MAT2A在生物学上的意义非常广泛，它不仅参与了一碳单位代谢和转硫途径，还与叶酸循环紧密相连。作为甲基化反应的关键辅助因子，MAT2A对DNA、RNA、蛋白质和脂质的甲基化修饰具有重要影响，这些甲基化修饰对基因表达调控、细胞信号传导、细胞增殖和分化等过程至关重要。MAT2A的功能异常与多种疾病相关，包括某些类型的癌症，例如在H3K27M突变的胶质瘤中，MAT2A的活性与肿瘤的生长和存活密切相关。因此，MAT2A不仅在细胞生理过程中发挥着核心作用，也是药物开发和疾病治疗中的潜在靶点。
热销产品
Recombinant Human S-adenosylmethionine synthase isoform type-2 (MAT2A) (CSB-YP013517HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MAT2A Antibody (CSB-PA013517LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA013517LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA013517LA01HU at dilution of 1:100
Immunofluorescent analysis of PC-3 cells using CSB-PA013517LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
MAT2A Antibodies
MAT2A for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA013517LA01HU | MAT2A Antibody | Human | ELISA, IHC, IF |
| CSB-PA013517LB01HU | MAT2A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA013517LC01HU | MAT2A Antibody, FITC conjugated | Human | |
| CSB-PA013517LD01HU | MAT2A Antibody, Biotin conjugated | Human | ELISA |
MAT2A Proteins
MAT2A Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-MP013517HU CSB-EP013517HU-B |
Recombinant Human S-adenosylmethionine synthase isoform type-2 (MAT2A) | Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP013517HU | Recombinant Human S-adenosylmethionine synthase isoform type-2 (MAT2A) | Baculovirus |
| CSB-EP013517HUc7 | Recombinant Human S-adenosylmethionine synthase isoform type-2 (MAT2A) | E.coli |
| CSB-YP013517HU | Recombinant Human S-adenosylmethionine synthase isoform type-2 (MAT2A) | Yeast |
| CSB-EP013517HU | Recombinant Human S-adenosylmethionine synthase isoform type-2 (MAT2A) | E.coli |
