MAN1B1

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase is a protein in humans that is encoded by MAN1B1 gene. Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).