MAGEA1
MAGEA1，即黑色素瘤相关抗原家族A1，是一种在多种肿瘤中表达的蛋白，特别是在黑色素瘤、肺癌、胃癌等恶性肿瘤中。MAGEA1属于MAGE（melanoma-associated antigen）家族成员，通常在睾丸组织中表达，而在其他正常组织中表达较低或不表达。MAGEA1的作用机制涉及调节细胞凋亡、影响肿瘤的发生发展，其在肿瘤细胞中的表达水平与肿瘤的侵袭性和预后密切相关。MAGEA1参与的信号通路包括Wnt/β-catenin信号通路，它通过激活该通路促进黑色素瘤细胞的上皮-间充质转化（EMT），提高黑色素瘤细胞的侵袭与迁移能力。此外，MAGEA1还可能参与其他信号通路，如成纤维细胞生长因子受体2（FGFR2）信号通路，通过调节纤维连接蛋白控制细胞的增殖和迁移。在生物学意义上，MAGEA1的异常表达与肿瘤的增殖、侵袭、转移等过程密切相关，是肿瘤治疗和免疫治疗的潜在靶点。MAGEA1的高表达通常与肿瘤的不良预后相关，其可作为肿瘤生物标志物用于诊断和治疗监测。
热销产品
Recombinant Human Melanoma-associated antigen 1 (MAGEA1) (CSB-YP013323HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP013323HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) MAGEA1.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP013323HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) MAGEA1.
MAGEA1 Antibody (CSB-PA013323ESR2HU)
验证数据
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA013323ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA013323ESR2HU at dilution of 1:100
Immunoprecipitating MAGEA1 in Hela whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-PA013323ESR2HU in Hela whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA013323ESR2HU (8µg) + Hela whole cell lysate (500µg)
Lane 3: Hela whole cell lysate (10µg)
MAGEA1 Antibodies
MAGEA1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA013323GA01HU | MAGEA1 Antibody | Human | ELISA,WB |
| CSB-PA013323ESR2HU | MAGEA1 Antibody | Human | ELISA, IHC, IP |
| CSB-PA003186 | MAGEA1 Antibody | Human | WB, IHC, ELISA |
MAGEA1 Proteins
MAGEA1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP013323HU | Recombinant Human Melanoma-associated antigen 1 (MAGEA1) | Yeast |
| CSB-MP013323HU | Recombinant Human Melanoma-associated antigen 1 (MAGEA1) | Mammalian cell |
| CSB-EP013323HU | Recombinant Human Melanoma-associated antigen 1 (MAGEA1) | E.coli |
| CSB-BP013323HU CSB-EP013323HU-B |
Recombinant Human Melanoma-associated antigen 1 (MAGEA1) | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP013323HUd9 | Recombinant Human Melanoma-associated antigen 1 (MAGEA1) | Mammalian cell |
MAGEA1 ELISA Kit
MAGEA1 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL013323HU | Human Melanoma-associated antigen 1(MAGEA1) ELISA kit | tissue homogenates, cell lysates | 0.039 ng/ml |
