MADCAM1
MAdCAM-1（粘膜血管地址素细胞粘附分子1）是免疫球蛋白超家族的一员，作为一种跨膜蛋白，它在肠道粘膜淋巴组织的血管内皮细胞上选择性表达。MAdCAM-1的结构包含三个免疫球蛋白样结构域和一个粘蛋白样区域，其中前两个结构域能够与淋巴细胞的归巢受体α4β7结合，而粘蛋白样结构域则与选择素L结合。它主要参与淋巴细胞的归巢过程，通过与其归巢受体的相互作用，引导淋巴细胞向粘膜部位定向迁移。此外，MAdCAM-1还在炎症反应中发挥重要作用，通过调节白细胞在粘膜环境中的通过和保留，影响炎症的发展。因此，MAdCAM-1在维持机体内淋巴细胞迁移和炎症调节中起到关键作用，成为治疗炎症性肠病等疾病的重要靶点。
热销产品
Recombinant Human Mucosal addressin cell adhesion molecule 1 (MADCAM1), partial (CSB-YP618776HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MADCAM1 Antibodies
MADCAM1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA295662 | MADCAM1 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA618776HA01HU | MADCAM1 Antibody | Human | ELISA, WB, IF |
| CSB-PA618776HB01HU | MADCAM1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA618776HC01HU | MADCAM1 Antibody, FITC conjugated | Human | |
| CSB-PA618776HD01HU | MADCAM1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA215817A0HU | MADCAM1 Recombinant Monoclonal Antibody | Human | ELISA, FC |
MADCAM1 Proteins
MADCAM1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP618776HU | Recombinant Human Mucosal addressin cell adhesion molecule 1 (MADCAM1), partial | Yeast |
| CSB-EP618776HU | Recombinant Human Mucosal addressin cell adhesion molecule 1 (MADCAM1), partial | E.coli |
| CSB-BP618776HU CSB-EP618776HU-B |
Recombinant Human Mucosal addressin cell adhesion molecule 1 (MADCAM1), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP618776HU | Recombinant Human Mucosal addressin cell adhesion molecule 1 (MADCAM1), partial | Mammalian cell |
| CSB-YP618776HUc7 | Recombinant Human Mucosal addressin cell adhesion molecule 1 (MADCAM1), partial | Yeast |
