Kras

KRAS，即Kirsten大鼠肉瘤病毒癌基因同源物”，别名KRAS4A和KRAS4B，这两种变体来源于同一基因的不同剪接形式。KRAS基因编码的蛋白质属于RAS超家族的小GTP酶，是一种在细胞内信号传导途径中起关键作用的分子开关。它通过与鸟嘌呤核苷二磷酸（GDP）或鸟嘌呤核苷三磷酸（GTP）结合，来调节自身的活性状态。在正常细胞中，KRAS受到上游信号如EGFR激活的严格控制，其活性周期性地在激活和失活之间转换，以维持细胞内环境的稳定。KRAS在生物学上的意义非常重要，它参与调控细胞的生长、分化、存活和迁移等关键生理过程。KRAS蛋白通过激活包括RAF-MEK-ERK（MAPK）通路、PI3K-AKT通路以及Ral-GEFs通路在内的多条下游信号通路，影响细胞的生理功能。当KRAS发生突变时，如常见的G12D、G12V、G13D等，它将被锁定在持续激活状态，导致细胞信号传导失衡，促进肿瘤细胞的无序增殖和存活，与多种肿瘤的发生发展密切相关。因此，KRAS是肿瘤治疗中一个极具挑战性和重要性的靶点，针对KRAS突变的靶向治疗正在成为癌症治疗研究的热点。

热销产品

KRAS Antibody (CSB-PA13967A0Rb)

验证数据

Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA13967A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA13967A0Rb at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA13967A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human GTPase KRas(KRAS) ELISA kit (CSB-EL012493HU)

验证数据

货号：CSB-EL012493HU

规格：96T/48T

灵敏度：5.8 pg/mL

检测范围：23.5 pg/mL-1500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Kras Antibody

Kras Protein

Kras ELISA Kit

Kras Antibodies

Kras for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA13969C0Rb	KRAS Antibody, FITC conjugated	Human
CSB-PA012493GA01HU	KRAS Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA13967A0Rb	KRAS Antibody	Human	ELISA, IHC, IF
CSB-PA13967B0Rb	KRAS Antibody, HRP conjugated	Human	ELISA
CSB-PA13967C0Rb	KRAS Antibody, FITC conjugated	Human
CSB-PA13967D0Rb	KRAS Antibody, Biotin conjugated	Human	ELISA
CSB-PA13969A0Rb	KRAS Antibody	Human, Mouse	ELISA, WB, IHC, IF

Kras Proteins

Kras Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP012493MO CSB-EP012493MO CSB-BP012493MO CSB-MP012493MO CSB-EP012493MO-B	Recombinant Mouse GTPase KRas (Kras)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Kras Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP012493HU CSB-EP012493HU CSB-BP012493HU CSB-MP012493HU CSB-EP012493HU-B	Recombinant Human GTPase KRas (KRAS)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP012493HU1	Recombinant Human GTPase KRas (KRAS), partial	E.coli

Kras Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP012493RA CSB-EP012493RA CSB-BP012493RA CSB-MP012493RA CSB-EP012493RA-B	Recombinant Rat GTPase KRas (Kras)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Kras Proteins for Meleagris gallopavo (Common turkey)

产品货号	产品名称	来源
CSB-YP012493MQV CSB-EP012493MQV CSB-BP012493MQV CSB-MP012493MQV CSB-EP012493MQV-B	Recombinant Meleagris gallopavo GTPase KRas (KRAS)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Kras Proteins for Cyprinus carpio (Common carp)

产品货号	产品名称	来源
CSB-YP012493EQE CSB-EP012493EQE CSB-BP012493EQE CSB-MP012493EQE CSB-EP012493EQE-B	Recombinant Cyprinus carpio GTPase KRas (kras)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Kras Proteins for Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus)

产品货号	产品名称	来源
CSB-YP012493KAAB CSB-EP012493KAAB CSB-BP012493KAAB CSB-MP012493KAAB CSB-EP012493KAAB-B	Recombinant Kryptolebias marmoratus GTPase KRas (kras)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli