INVS

Inversin是人体中由INVS基因编码的一种蛋白质。它在正常肾脏发育和左右轴的建立中起着必要作用。可能作为不同Wnt信号通路之间的分子开关。通过靶向细胞质中的Disheveled（DVL1）使其被泛素蛋白酶降解，从而抑制了经典Wnt通路。这表明，在肾脏发育中，它在对抗Wnt信号抑制小管上皮细胞末期分化方面是必要的。与NPHP1、NPHP4和RPGRIP1L/NPHP8（类似物）共同参与调节肾细胞顶部结合的组织。似乎不是纤毛发生的严格必需品（类似）。

Inversin is a protein in humans that is encoded by INVS gene. Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).