IGF2BP3

IGF2BP3，即胰岛素样生长因子2的mRNA结合蛋白3，是一种RNA结合蛋白，其结构包含RNA结合结构域、RRM结构域和蛋白质互作结构域。它通过与mRNA结合，促进其稳定性和翻译过程，从而调控细胞的增殖、分化和存活。在生物学过程中，IGF2BP3扮演着重要角色，尤其在发育、肿瘤发生和干细胞形成等方面。作为N6-腺苷酸甲基化阅读蛋白，它还能识别m6A GC序列，影响下游靶基因mRNA的稳定性和翻译。关于其信号通路，IGF2BP3可能通过与特定分子或蛋白质相互作用，形成复杂的信号网络，如在结直肠癌中，它与METTL14合作，通过m6A依赖的方式促进EGFR mRNA的稳定性和翻译，进而激活EGFR通路。因此，深入研究IGF2BP3的信号通路和调控机制对于理解其生物学功能以及开发新的治疗策略具有重要意义。

热销产品

● Recombinant Human Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

验证数据

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

● IGF2BP3 Antibody

验证数据

SDS

Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, HEK293 whole cell lysate, Mouse brain tissue
All lanes: IGF2BP3 antibody at 2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 64, 22 kDa
Observed band size: 64, 50 kDa

IHC

Immunofluorescent analysis of MCF-7 cells using CSB-PA011092LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

IHC

Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA011092LA01HU at dilution of 1:100

IHC

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA011092LA01HU at dilution of 1:100

IGF2BP3 Antibody

IGF2BP3 Protein

IGF2BP3 ELISA Kit

IGF2BP3 Antibodies

IGF2BP3 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA011092GA01HU	IGF2BP3 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA745585	IGF2BP3 Antibody	Human,Mouse	ELISA,WB
CSB-PA011092LA01HU	IGF2BP3 Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA011092LB01HU	IGF2BP3 Antibody, HRP conjugated	Human	ELISA
CSB-PA011092LC01HU	IGF2BP3 Antibody, FITC conjugated	Human
CSB-PA011092LD01HU	IGF2BP3 Antibody, Biotin conjugated	Human	ELISA

IGF2BP3 Proteins

IGF2BP3 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP011092HU CSB-BP011092HU CSB-MP011092HU CSB-EP011092HU-B	Recombinant Human Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP011092HU	Recombinant Human Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)	E.coli