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IDO1

IDO1,即吲哚胺2,3-双加氧酶1,它是一种由IDO1基因编码的酶,主要分布在肝脏外的各种组织和细胞中,如胸腺、小肠、附睾、胎盘、肾脏、脾脏、胰腺、中枢神经系统等。IDO1的主要作用机制是催化色氨酸转化为犬尿氨酸,这一过程是色氨酸代谢的限速步骤。在信号通路方面,IDO1的活性受到多种细胞因子如IFN-γ、TNF-α的调控,这些细胞因子通过作用于IDO1基因的干扰素刺激反应元素(GAS)和干扰素激活位点(ISRE)来诱导IDO1的表达。在生物学意义上,IDO1在维持免疫稳态、调节免疫应答中发挥重要作用,尤其是在妊娠期间防止胎儿排斥反应、肿瘤免疫逃逸、以及某些感染性疾病中。IDO1的异常表达或活性与多种疾病包括肿瘤、自身免疫病和神经退行性疾病等的发生发展密切相关。

热销产品

Recombinant Human Indoleamine 2,3-dioxygenase 1 (IDO1) (CSB-EP010996HU)

验证数据

CSB-EP010996HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP010996HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010996HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IDO1.

CSB-EP010996HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010996HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IDO1.

IDO1 Recombinant Monoclonal Antibody (CSB-RA215054A0HU)

验证数据

CSB-RA215054A0HU

IHC image of CSB-RA215054A0HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Mouse Indoleamine 2,3-dioxygenase 1(IDO1) ELISA kit (CSB-EL010996MO)

验证数据

CSB-EL010996MO 标准曲线

货号:CSB-EL010996MO

规格:96T/48T

灵敏度:15.6 pg/mL

检测范围:62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

IDO1 Antibodies

IDO1 for Homo sapiens (Human)

IDO1 Proteins

IDO1 Proteins for Homo sapiens (Human)

IDO1 ELISA Kit

IDO1 ELISA Kit for Homo sapiens (Human)