IDH2
IDH2（异柠檬酸脱氢酶2）是一种线粒体酶，由α、β和γ三个亚基组成，形成α2βγ异源四聚体，并进一步组装成八聚体结构。IDH2的主要功能是催化异柠檬酸氧化脱羧生成α-酮戊二酸（α-KG），同时将NADP+转化为NADPH，参与三羧酸循环（TCA cycle），对细胞代谢和能量产生至关重要。NADPH作为一种抗氧化剂，有助于维持细胞氧化还原状态的稳定，并促进脂肪酸等大分子的合成。IDH2参与的信号通路包括三羧酸循环、氧化还原稳态的维持，以及与肿瘤发生发展相关的代谢途径。IDH2的突变在急性髓系白血病（AML）等肿瘤中较为常见，与肿瘤细胞的异常代谢和分化障碍有关。因此，IDH2不仅在细胞代谢中发挥关键作用，其突变还与肿瘤的发生发展密切相关，使其成为研究肿瘤代谢和开发新疗法的重要靶点。
热销产品
IDH2 Antibody (CSB-PA010990ESR1HU)
验证数据
Western blot
All lanes: IDH2 antibody at 5µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 51, 46 kDa
Observed band size: 51 kDa
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010990ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA010990ESR1HU at dilution of 1:100
IDH2 Antibodies
IDH2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA010990GA01HU | IDH2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010990ESR2HU | IDH2 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA010990ESR1HU | IDH2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA148538 | IDH2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA586287 | IDH2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
IDH2 Proteins
IDH2 Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010990PI CSB-EP010990PI CSB-BP010990PI CSB-MP010990PI CSB-EP010990PI-B |
Recombinant Pig Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010990HU CSB-EP010990HU CSB-BP010990HU CSB-MP010990HU CSB-EP010990HU-B |
Recombinant Human Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010990MO CSB-EP010990MO CSB-BP010990MO CSB-MP010990MO CSB-EP010990MO-B |
Recombinant Mouse Isocitrate dehydrogenase [NADP], mitochondrial (Idh2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010990RA CSB-EP010990RA CSB-BP010990RA CSB-MP010990RA CSB-EP010990RA-B |
Recombinant Rat Isocitrate dehydrogenase [NADP], mitochondrial (Idh2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP310511DOA CSB-EP310511DOA CSB-BP310511DOA CSB-MP310511DOA CSB-EP310511DOA-B |
Recombinant Arabidopsis thaliana Isocitrate dehydrogenase [NAD] regulatory subunit 2, mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP340961SVG CSB-EP340961SVG CSB-BP340961SVG CSB-MP340961SVG CSB-EP340961SVG-B |
Recombinant Saccharomyces cerevisiae Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP528404KBK CSB-EP528404KBK CSB-BP528404KBK CSB-MP528404KBK CSB-EP528404KBK-B |
Recombinant Kluyveromyces lactis Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP680991MOV CSB-EP680991MOV CSB-BP680991MOV CSB-MP680991MOV CSB-EP680991MOV-B |
Recombinant Macaca fascicularis Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDH2 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP891493SXV CSB-EP891493SXV CSB-BP891493SXV CSB-MP891493SXV CSB-EP891493SXV-B |
Recombinant Schizosaccharomyces pombe Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (idh2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
