HMGB1
HMGB1（High Mobility Group Box 1）是一种高迁移性群蛋白，属于染色质结构蛋白家族。它在细胞核内以特定的方式与DNA结合，帮助调节基因表达。HMGB1分子通常由两个DNA结合域（A盒和B盒）以及一个非特异性连结区域（C盒）组成。HMGB1在细胞生物学中具有多种功能。在细胞核中，HMGB1可以结合DNA，调节基因转录和染色质结构，参与基因表达调控。在细胞质中，HMGB1在细胞应激、炎症和免疫反应中发挥重要作用。当细胞受到损伤或遭受感染时，HMGB1可以被释放到胞外，与免疫细胞上的特定受体（如RAGE、TLR4等）结合，触发免疫细胞的活化和炎症反应。HMGB1被认为是一种重要的促炎因子，它可以引导免疫细胞的迁移和激活，增强炎症反应，从而参与免疫应答和组织修复。HMGB1也与自噬过程有关，可能在自噬的调节和执行中发挥作用。HMGB1的研究已经在多个领域得到广泛的关注，包括基因调控、炎症生物学、免疫学和肿瘤学等。它的作用在疾病的发展和治疗中具有重要意义。
热销产品
● HMGB1 Recombinant Monoclonal Antibody CSB-RA010553MA1HU
验证数据
IHC image of CSB-RA010553MA1HU diluted at 1:100 and staining in paraffin-embedded human salivary gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
Overlay Peak curve showing Hela cells stained with CSB-RA010553MA1HU (red line) at 1:50. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
HMGB1 Antibodies
HMGB1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA01604A0Rb | HMGB1 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA01604B0Rb | HMGB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA01604C0Rb | HMGB1 Antibody, FITC conjugated | Human | |
| CSB-PA01604D0Rb | HMGB1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA010553GA01HU | HMGB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA049959 | HMGB1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000149 | Acetyl-HMGB1 (K12) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA002937 | HMGB1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA005927 | HMGB1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA995991 | HMGB1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA225274 | HMGB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010553YA01HU | HMGB1 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA010553YB01HU | HMGB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA010553YC01HU | HMGB1 Antibody, FITC conjugated | Human | |
| CSB-PA010553YD01HU | HMGB1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA439052A0HU | HMGB1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-RA010553MA1HU | HMGB1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF, FC |
HMGB1 for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA010553NA01RA | Hmgb1 Antibody | Rat | ELISA, WB |
| CSB-PA010553NB01RA | Hmgb1 Antibody, HRP conjugated | Rat | ELISA |
| CSB-PA010553NC01RA | Hmgb1 Antibody, FITC conjugated | Rat | |
| CSB-PA010553ND01RA | Hmgb1 Antibody, Biotin conjugated | Rat | ELISA |
| CSB-PA010553NA01MO | Hmgb1 Antibody | Rat | ELISA, WB |
HMGB1 Proteins
HMGB1 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010553BO CSB-EP010553BO CSB-BP010553BO CSB-MP010553BO CSB-EP010553BO-B |
Recombinant Bovine High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010553PI CSB-BP010553PI CSB-MP010553PI CSB-EP010553PI-B |
Recombinant Pig High mobility group protein B1 (HMGB1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-BP010553MO CSB-MP010553MO CSB-EP010553MO-B |
Recombinant Mouse High mobility group protein B1 (Hmgb1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP010553MO | Recombinant Mouse High mobility group protein B1 (Hmgb1) | E.coli |
| CSB-YP010553MO | Recombinant Mouse High mobility group protein B1 (Hmgb1) | Yeast |
HMGB1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010553RA | Recombinant Rat High mobility group protein B1 (Hmgb1) | Yeast |
| CSB-EP010553RA | Recombinant Rat High mobility group protein B1 (Hmgb1) | E.coli |
| CSB-BP010553RA CSB-MP010553RA CSB-EP010553RA-B |
Recombinant Rat High mobility group protein B1 (Hmgb1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP010553RAa1 | Recombinant Rat High mobility group protein B1 (Hmgb1) | Yeast |
HMGB1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010553HU | Recombinant Human High mobility group protein B1 (HMGB1), partial | Yeast |
| CSB-RP016044h | Recombinant Human High mobility group protein B1 (HMGB1), partial | E.coli |
| CSB-EP010553HU CSB-BP010553HU CSB-EP010553HU-B |
Recombinant Human High mobility group protein B1 (Hmgb1), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP010553MO1 | Recombinant Mouse High mobility group protein B1 (HMGB1), partial | E.coli |
| CSB-MP010553HU | Recombinant Human High mobility group protein B1 (HMGB1) | Mammalian cell |
HMGB1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP362058DXU CSB-EP362058DXU CSB-BP362058DXU CSB-MP362058DXU CSB-EP362058DXU-B |
Recombinant Cricetulus griseus High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Papio anubis (Olive baboon)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP434996ERI CSB-EP434996ERI CSB-BP434996ERI CSB-MP434996ERI CSB-EP434996ERI-B |
Recombinant Papio anubis High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP523735DOA CSB-EP523735DOA CSB-BP523735DOA CSB-MP523735DOA CSB-EP523735DOA-B |
Recombinant Arabidopsis thaliana High mobility group B protein 1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Callithrix jacchus (White-tufted-ear marmoset)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP533334CYL CSB-EP533334CYL CSB-BP533334CYL CSB-MP533334CYL CSB-EP533334CYL-B |
Recombinant Callithrix jacchus High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Callicebus moloch (Dusky titi monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP541463CYE CSB-EP541463CYE CSB-BP541463CYE CSB-MP541463CYE CSB-EP541463CYE-B |
Recombinant Callicebus moloch High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Equus caballus (Horse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP600961HO CSB-EP600961HO CSB-BP600961HO CSB-MP600961HO CSB-EP600961HO-B |
Recombinant Horse High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP703137MOV CSB-EP703137MOV CSB-BP703137MOV CSB-MP703137MOV CSB-EP703137MOV-B |
Recombinant Macaca fascicularis High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP751094DO CSB-EP751094DO CSB-BP751094DO CSB-MP751094DO CSB-EP751094DO-B |
Recombinant Dog High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 ELISA Kit
HMGB1 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL010553DO | Dog High mobility group protein B1(HMGB1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
HMGB1 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E08223h | Human High mobility group protein B1,HMGB-1 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 19.5 pg/mL |
HMGB1 ELISA Kit for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E08225m | Mouse High mobility group protein B1,HMGB-1 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
HMGB1 ELISA Kit for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL010553PI | Pig High mobility group protein B1(HMGB1) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
HMGB1 ELISA Kit for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E08224r | Rat High mobility group protein B1,HMGB-1 ELISA Kit | serum, plasma, tissue homogenates |
