HAT1
HAT1，即组蛋白乙酰转移酶1，别名KAT1。它是一种B型组蛋白乙酰转移酶，由人类基因组编码，主要在细胞质中发挥作用。HAT1的作用机制是通过其催化结构域将乙酰辅酶A上的乙酰基转移到新合成的组蛋白H4的赖氨酸残基上，特别是H4K5和H4K12，以及在较小程度上乙酰化组蛋白H2A的K5。这种乙酰化过程对于新合成DNA链的染色质组装至关重要，影响基因表达和染色质结构。HAT1在调控细胞周期进程、DNA复制、修复以及转录调控中发挥重要作用。HAT1的异常表达或活性失调与多种疾病相关，包括癌症。HAT1还参与了肿瘤发生中组蛋白和非组蛋白的琥珀酰化，影响癌细胞的表观遗传调控和基因表达。
热销产品
HAT1 Antibody (CSB-PA010143ESR2HU)
验证数据
Western blot
All lanes: HAT1 antibody at 3µg/ml
Lane 1: MCF-7 whole cell lysate
Lane 2: 293T whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 50, 40 kDa
Observed band size: 50 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA010143ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010143ESR2HU at dilution of 1:100
HAT1 Antibodies
HAT1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA010143GA01HU | HAT1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010143ESR2HU | HAT1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA928867 | HAT1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA070071 | HAT1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA010143EA01HU | HAT1 Antibody | Human, Rat | ELISA, WB, IF |
HAT1 Proteins
HAT1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010143HU CSB-EP010143HU CSB-BP010143HU CSB-MP010143HU CSB-EP010143HU-B |
Recombinant Human Histone acetyltransferase type B catalytic subunit (HAT1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
