Ffar4
FFAR4,即游离脂肪酸受体4,别名GPR120、Omega-3脂肪酸受体1(O3FAR1)、G-蛋白偶联受体120等。FFAR4是一种G蛋白偶联受体(GPCR),主要在肠道上皮细胞、脂肪细胞、巨噬细胞等组织中表达。它的作用机制是通过与长链脂肪酸,尤其是Omega-3多不饱和脂肪酸(ω-3 PUFA)结合,激活受体,进而通过Gαs蛋白激活腺苷酸环化酶(AC),导致cAMP水平增加,激活PKA和EPAC等下游信号通路,从而调节代谢和炎症反应。FFAR4在生物学上的意义主要体现在其对代谢和免疫反应的调节作用。作为Omega-3脂肪酸的传感器,FFAR4的激活可以促进胰高血糖素样肽-1(GLP-1)和肽YY(PYY)的释放,有助于改善胰岛素敏感性,降低血糖,对抗代谢综合征。此外,FFAR4在免疫细胞中的作用还包括调节巨噬细胞的极化状态,影响炎症因子的产生,从而在炎症性疾病和自身免疫性疾病中发挥作用。FFAR4的功能异常与多种疾病相关,包括2型糖尿病、肥胖症和某些类型的癌症。因此,FFAR4是治疗代谢性疾病和炎症性疾病的潜在药物靶点。
热销产品
验证数据
Western Blot analysis of HEPG2-UV cells using GPR120 Polyclonal Antibody
Western Blot analysis of HepG2-UV cells using GPR120 Polyclonal Antibody
Ffar4 Antibodies
Ffar4 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA002756 | FFAR4 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
Ffar4 Proteins
Ffar4 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP009743MOV1 CSB-EP009743MOV1 CSB-BP009743MOV1 CSB-MP009743MOV1 CSB-EP009743MOV1-B |
Recombinant Macaca fascicularis Omega-3 fatty acid receptor 1 (O3FAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF009743MOV | Recombinant Macaca fascicularis Omega-3 fatty acid receptor 1 (O3FAR1) | in vitro E.coli expression system |
Ffar4 Proteins for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP639132RA1 CSB-EP639132RA1 CSB-BP639132RA1 CSB-MP639132RA1 CSB-EP639132RA1-B |
Recombinant Rat Omega-3 fatty acid receptor 1 (O3far1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF639132RA | Recombinant Rat Omega-3 fatty acid receptor 1 (O3far1) | in vitro E.coli expression system |
Ffar4 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP711851HU1 CSB-EP711851HU1 CSB-BP711851HU1 CSB-MP711851HU1 CSB-EP711851HU1-B |
Recombinant Human Free fatty acid receptor 4 (FFAR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF711851HU | Recombinant Human Free fatty acid receptor 4 (FFAR4) | in vitro E.coli expression system |
Ffar4 Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP749243MO1 CSB-EP749243MO1 CSB-BP749243MO1 CSB-MP749243MO1 CSB-EP749243MO1-B |
Recombinant Mouse Omega-3 fatty acid receptor 1 (O3far1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF749243MO | Recombinant Mouse Omega-3 fatty acid receptor 1 (O3far1) | in vitro E.coli expression system |