FADD

FAS相关死亡区结构域蛋白是由FADD基因编码的人类蛋白质。它作为一种凋亡适配分子，将半胱氨酸蛋白酶8或半胱氨酸蛋白酶10招募到活化的Fas（CD95）或TNFR-1受体上。形成的复合物称为死亡诱导信号复合物（DISC），并对半胱氨酸蛋白酶8进行蛋白酶活化。活性半胱氨酸蛋白酶8启动介导细胞凋亡的下一级半胱氨酸蛋白酶级联反应。该蛋白质参与干扰素介导的抗病毒免疫应答，在干扰素信号转导的正向调控中发挥作用。
FAS-associated death domain protein is a protein in humans that is encoded by FADD gene. Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.