DSG2
DSG2(Desmoglein-2)，是一种细胞粘附蛋白，属于钙黏蛋白家族的一员。主要在上皮细胞中表达，如皮肤、心脏、肺、肠道等组织。DSG2的结构特点包括外部区域和细胞膜跨膜区。外部区域包含多个结构域，其中包括多个钙离子结合位点，这些结构域有助于DSG2与其他细胞间连接蛋白（如其他DSG蛋白或Plakophilin）相互作用，形成一种称为"桥粒"（desmosomes）的连接结构。 这种"桥粒"连接可以使上皮细胞紧密连接在一起，增强组织的结构稳定性，并提供细胞间的强大黏附力。这对于维持组织的完整性和稳定性至关重要，尤其是在受到外部力量时，如心脏的搏动、皮肤的拉伸等情况下，它可以使上皮组织具有强大的耐受力。DSG2的功能异常可能导致一些疾病。例如，某些遗传性皮肤疾病和心脏病与DSG2的突变或异常表达有关。
更多相关阅读：DSG2：桥粒芯蛋白家族DSGs表达最广泛的成员，心肌病、腺病毒和肿瘤新兴靶点？
热销产品
● DSG2 Recombinant Monoclonal Antibody CSB-RA622752MA1HU
验证数据
The Binding Activity of DSG2 with anti-DSG2 antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DSG2 (CSB-MP622752HU) at 2 μg/mL can bind Anti-DSG2 recombinant antibody，the EC50 is 20.26-38.00 ng/mL
● Recombinant Human Desmoglein-2(DSG2),partial (Active) CSB-MP622752HU
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DSG2 at 2μg/mL can bind Anti-DSG2 recombinant antibody (CSB-RA622752MA1HU)， the EC50 is 20.26-38.00 ng/mL
DSG2 Antibodies
DSG2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA007204GA01HU | DSG2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA007839 | DSG2 Antibody | Human | WB, ELISA |
| CSB-PA025645 | DSG2 Antibody | Human | ELISA,IHC |
| CSB-PA401715 | DSG2 Antibody | Human | ELISA,IHC |
| CSB-PA622752LA01HU | DSG2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA622752LB01HU | DSG2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA622752LC01HU | DSG2 Antibody, FITC conjugated | Human | |
| CSB-PA622752LD01HU | DSG2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA622752MA1HU | DSG2 Recombinant Monoclonal Antibody | Human | ELISA |
DSG2 Proteins
DSG2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007204MO CSB-BP007204MO CSB-MP007204MO CSB-EP007204MO-B |
Recombinant Mouse Desmoglein-2 (Dsg2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP007204MO | Recombinant Mouse Desmoglein-2 (Dsg2), partial | E.coli |
DSG2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP622752HU CSB-EP622752HU CSB-EP622752HU-B |
Recombinant Human Desmoglein-2 (DSG2), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-EP622752HUb1 | Recombinant Human Desmoglein-2 (DSG2), partial | E.coli |
| CSB-BP622752HU | Recombinant Human Desmoglein-2 (DSG2), partial | Baculovirus |
| CSB-EP622752HUa0 | Recombinant Human Desmoglein-2 (DSG2), partial | E.coli |
| CSB-EP622752HUb0 | Recombinant Human Desmoglein-2 (DSG2), partial | E.coli |
| CSB-MP622752HU | Recombinant Human Desmoglein-2 (DSG2), partial (Active) | Mammalian cell |
