Col18a1
COL18A1，作为胶原蛋白家族的重要成员，具有独特的分子结构，通过其特定的氨基酸序列在细胞外基质中发挥关键作用。在功能上，COL18A1不仅参与视网膜的形成和维持，确保视网膜正常功能，还调节内皮细胞的迁移、增殖和粘附等过程，对血管生成、伤口愈合以及胎盘循环建立至关重要。同时，COL18A1能够特异性地抑制内皮细胞增殖和血管生成，通过抑制内皮细胞迁移和粘附，下调血管生成相关基因表达来实现。在信号通路上，COL18A1通过与内皮细胞表面受体结合，触发一系列细胞内信号转导，涉及转谷氨酰胺酶2、肝素、整合素α5 beta 1和αV beta 3等分子的相互作用，导致细胞骨架重排、基因表达改变以及细胞行为调整。此外，COL18A1的突变与某些疾病如诺布洛赫综合征相关，突显其在维持正常生理功能和预防疾病中的重要作用。尽管我们对COL18A1已有一定了解，但仍需进一步探索其未知领域，以揭示其在生理和病理过程中的更多作用，并为新治疗策略的开发提供线索。
热销产品
Recombinant Human Collagen alpha-1 (XVIII) chain (COL18A1), partial
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP005725HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) COL18A1.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP005725HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) COL18A1.
Col18a1 Antibodies
Col18a1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA005725GA01HU | COL18A1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA044575 | COL18A1 Antibody | Human | ELISA,IHC |
| CSB-PA057835 | COL18A1 Antibody | Human,Mouse | ELISA,IHC,IF |
| CSB-PA060191 | COL18A1 Antibody | Human,Mouse | IHC, IF, ELISA |
| CSB-PA010559 | COL18A1 Antibody | Human,Mouse | IHC, ELISA |
| CSB-PA199023 | COL18A1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA005725LA01HU | COL18A1 Antibody | Human | ELISA, IF |
| CSB-PA005725LB01HU | COL18A1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA005725LC01HU | COL18A1 Antibody, FITC conjugated | Human | |
| CSB-PA005725LD01HU | COL18A1 Antibody, Biotin conjugated | Human | ELISA |
Col18a1 Proteins
Col18a1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005725HU | Recombinant Human Collagen alpha-1 (XVIII) chain (COL18A1), partial | Yeast |
| CSB-EP005725HU | Recombinant Human Collagen alpha-1 (XVIII) chain (COL18A1), partial | E.coli |
| CSB-BP005725HU CSB-MP005725HU CSB-EP005725HU-B |
Recombinant Human Collagen alpha-1 (XVIII) chain (COL18A1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
