CD20
CD20,即B淋巴细胞抗原,别名MS4A1,是一种在B细胞表面表达的跨膜磷蛋白。它在B细胞的发育过程中,从前体B细胞到成熟B细胞的各个阶段均有表达,但在浆细胞和造血干细胞中不表达。CD20在超过95%的B细胞淋巴瘤中高度表达,而在正常组织中表达较低,使其成为治疗B细胞相关疾病的有效靶点。CD20的作用机制涉及调节B细胞的活化、增殖和分化。抗CD20单克隆抗体,如利妥昔单抗,通过激活补体系统和抗体依赖性细胞介导的细胞毒性作用(ADCC)来消灭B细胞来源的肿瘤细胞。此外,CD20还参与B细胞受体(BCR)的信号传导,与多种细胞表面蛋白相互作用,对B细胞的生物学功能具有重要意义。
热销产品
Recombinant Human B-lymphocyte antigen CD20 (MS4A1) (CSB-CF015007HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MS4A1 Recombinant Monoclonal Antibody (CSB-RA015007MA3HU)
验证数据
The Binding Activity of Human MS4A1 with Anti-MS4A1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MS4A1 (CSB-MP015007HU) at 5 μg/mL can bind Anti-MS4A1 recombinant antibody, the EC50 is 6.959-19.70 ng/mL.
The Binding Activity of Dog MS4A1 with Anti-MS4A1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Dog MS4A1 (CSB-MP661636DO) at 10 μg/mL can bind Anti-MS4A1 recombinant antibody, the EC50 is 147.3-199.0 ng/mL.
The Binding Activity of Macaca fascicularis CD20 with Anti-CD20 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CD20 (CSB-MP4516MOV) at 10 μg/mL can bind Anti-CD20 recombinant antibody, the EC50 is 10.65-15.26 ng/mL.
The VLPs (CSB-MP3838) is negative control.
CD20 Antibodies
CD20 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA015007DSR2HU | MS4A1 Antibody | Human | ELISA, IHC |
CSB-PA001433 | MS4A1 Antibody | Human | WB, ELISA |
CSB-PA006161 | MS4A1 Antibody | Human | WB, ELISA |
CSB-RA015007A0HU | CD20 Recombinant Monoclonal Antibody | Human | ELISA |
CSB-MA996413 | MS4A1 Monoclonal Antibody | Human | ELISA, IHC |
CSB-RA015007A1HU | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA |
CSB-RA015007MA3HU | MS4A1 Recombinant Monoclonal Antibody | Human, Dog, Macaca fascicularis | ELISA |
CSB-RA015007MA4HU | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
CD20 for H, M, R
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-MA000204 | MS4A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
CD20 Proteins
CD20 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP015007HU1 | Recombinant Human B-lymphocyte antigen CD20 (MS4A1), partial | Yeast |
CSB-CF015007HU | Recombinant Human B-lymphocyte antigen CD20 (MS4A1) | in vitro E.coli expression system |
CSB-EP015007HU1 CSB-BP015007HU1 CSB-MP015007HU1 CSB-EP015007HU1-B |
Recombinant Human B-lymphocyte antigen CD20 (MS4A1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP015007HU | Recombinant Human B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active) | Mammalian cell |
CSB-EP015007HU2 | Recombinant Human B-lymphocyte antigen CD20 (MS4A1), partial | E.coli |
CSB-MP015007HU-D | Recombinant Human B-lymphocyte antigen CD20(MS4A1)-Detergent (Active) | Mammalian cell |
CD20 ELISA Kit
CD20 ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-E14007h | Human B-lymphocyte antigen (CD20) ELISA Kit | serum, plasma, tissue homogenates | 0.78 ng/mL |