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CD20

CD20,即B淋巴细胞抗原,别名MS4A1,是一种在B细胞表面表达的跨膜磷蛋白。它在B细胞的发育过程中,从前体B细胞到成熟B细胞的各个阶段均有表达,但在浆细胞和造血干细胞中不表达。CD20在超过95%的B细胞淋巴瘤中高度表达,而在正常组织中表达较低,使其成为治疗B细胞相关疾病的有效靶点。CD20的作用机制涉及调节B细胞的活化、增殖和分化。抗CD20单克隆抗体,如利妥昔单抗,通过激活补体系统和抗体依赖性细胞介导的细胞毒性作用(ADCC)来消灭B细胞来源的肿瘤细胞。此外,CD20还参与B细胞受体(BCR)的信号传导,与多种细胞表面蛋白相互作用,对B细胞的生物学功能具有重要意义。

热销产品

Recombinant Human B-lymphocyte antigen CD20 (MS4A1) (CSB-CF015007HU)

验证数据

CSB-CF015007HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

MS4A1 Recombinant Monoclonal Antibody (CSB-RA015007MA3HU)

验证数据

CSB-RA015007MA3HU

The Binding Activity of Human MS4A1 with Anti-MS4A1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MS4A1 (CSB-MP015007HU) at 5 μg/mL can bind Anti-MS4A1 recombinant antibody, the EC50 is 6.959-19.70 ng/mL.

CSB-RA015007MA3HU

The Binding Activity of Dog MS4A1 with Anti-MS4A1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Dog MS4A1 (CSB-MP661636DO) at 10 μg/mL can bind Anti-MS4A1 recombinant antibody, the EC50 is 147.3-199.0 ng/mL.

CSB-RA015007MA3HU

The Binding Activity of Macaca fascicularis CD20 with Anti-CD20 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CD20 (CSB-MP4516MOV) at 10 μg/mL can bind Anti-CD20 recombinant antibody, the EC50 is 10.65-15.26 ng/mL.
The VLPs (CSB-MP3838) is negative control.

CD20 Antibodies

CD20 for Homo sapiens (Human)

CD20 for H, M, R

CD20 Proteins

CD20 Proteins for Homo sapiens (Human)

CD20 ELISA Kit

CD20 ELISA Kit for Homo sapiens (Human)