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CD147

CD147,(也称为Basigin或EMMPRIN),是一种跨膜蛋白,属于免疫球蛋白超家族,其结构含有一个细胞外N端和一个胞内C端。它有一个Ig-like(免疫球蛋白样)细胞外结构域,可与其他蛋白质发生相互作用。CD147广泛表达在许多细胞类型中,包括免疫细胞、白血球、红血球、神经细胞、胶质细胞、肿瘤细胞等。它在细胞间黏附和迁移过程中发挥重要作用,并参与多种生物学过程,如细胞的增殖、侵袭、转移以及免疫细胞的活化和炎症反应等。 在肿瘤学中,CD147被认为是一种肿瘤相关标志物,因为它在多种肿瘤细胞表面的表达水平明显升高,与肿瘤细胞的侵袭和转移有关。CD147还参与调节肿瘤微环境中的细胞间相互作用,对肿瘤的生长和进展具有一定的影响。此外,CD147在免疫调节和感染过程中也发挥着重要作用。它与病原体感染、炎症反应和免疫细胞的活化和迁移等过程密切相关。是疾病治疗和新药开发的潜在靶点。

热销产品

Recombinant Human Basigin(BSG),partial (Active)

验证数据

High Purity Validated by SDS-PAGE
CSB-MP002831HU1 SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA
Activity assay of CSB-MP002831HU1

Activity: Measured by its binding ability in a functional ELISA. Immobilized CD147 at 2 μg/ml can bind Anti-CD147 recombinant Antibody, the EC50 is 21.95-33.12 ng/ml.

CD147 Recombinant Monoclonal Antibody CSB-RA002831A0HU

验证数据

Western Blot
CSB-RA002831A0HU WB

Positive WB detected in: HepG2 whole cell lysate, ntera2 whole cell lysate, A549 whole cell lysate, U251 whole cell lysate

All lanes: CD147 antibody at 1:1000

Secondary

Goat polyclonal to mouse IgG at 1/50000 dilution

Predicted band size: 42, 29, 23, 19 KDa

Observed band size: 35, 50-60 KDa

CD147 Antibodies

CD147 for Homo sapiens (Human)

CD147 Proteins

CD147 Proteins for Mus musculus (Mouse)

CD147 Proteins for Homo sapiens (Human)

CD147 Proteins for Rattus norvegicus (Rat)

CD147 Proteins for Oryctolagus cuniculus (Rabbit)

CD147 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

CD147 ELISA Kit

CD147 ELISA Kit for Homo sapiens (Human)