Bcl2
BCL2，即B细胞淋巴瘤/白血病-2基因，别名包括Bcl-2家族中的抗凋亡蛋白，如Bcl-2、Bcl-XL、Bcl-W、Mcl-1等。它最初在血液淋巴细胞中被发现，能够显著抑制细胞死亡。BCL2基因的作用机制复杂，主要通过调控线粒体途径来抑制细胞凋亡，它能够阻止细胞色素c的释放，抑制活化的Caspases对线粒体的影响，从而维持细胞生存。此外，BCL2还能通过抗氧化作用、抑制钙离子跨膜流动和调节离子通道蛋白功能等多种机制来发挥作用。BCL2在细胞凋亡的信号通路中扮演着关键角色，它通过与Bax等促凋亡蛋白相互作用，形成二聚体，调节线粒体膜的通透性，进而影响细胞色素c的释放和Caspase级联反应的激活。BCL2的生物学意义重大，它不仅在细胞存活和凋亡的平衡中发挥作用，还与多种疾病的发生发展密切相关，包括癌症、神经退行性疾病等。BCL2的功能失调可能导致细胞凋亡途径的异常激活，影响细胞的正常生理功能。
热销产品
Recombinant Rat Apoptosis regulator Bcl-2 (Bcl2) (CSB-CF002611RA)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
BCL2 Recombinant Monoclonal Antibody (CSB-RA564360A0HU)
验证数据
Western Blot
Positive WB detected in: 293 whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, U-937 whole cell lysate, THP-1 whole cell lysate, Raji whole cell lysate, Mouse Spleen whole cell lysate
All lanes: Bcl-2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 27, 23 kDa
Observed band size: 27 kDa
IHC image of CSB-RA564360A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Rat B-cell CLL/lymphoma 2 (BCL2) ELISA kit (CSB-E08854r)
验证数据
货号：CSB-E08854r
规格：96T/48T
灵敏度：0.078 ng/mL
检测范围：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
Bcl2 Antibodies
Bcl2 for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA002611LC01MO | Bcl2 Antibody, FITC conjugated | Mouse | |
| CSB-PA002611LA01MO | Bcl2 Antibody | Mouse | ELISA, IHC |
| CSB-PA002611LB01MO | Bcl2 Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA006342 | Phospho-BCL2 (S70) Antibody | Mouse,Rat | WB, ELISA |
Bcl2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA002611GA01HU | BCL2 Antibody | Human,Mouse,Rat,Guinea pig | ELISA,WB,IHC |
| CSB-PA187601 | BCL2 (Ab-56) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA129411 | BCL2 (Ab-70) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA206782 | Phospho-BCL2 (Thr56) Antibody | Human | ELISA,IHC |
| CSB-PA824266 | Phospho-BCL2 (Ser70) Antibody | Human | ELISA,IHC |
| CSB-PA971921 | Phospho-BCL2 (Ser87) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000484 | Phospho-BCL2 (S70) Antibody | Human,Monkey | WB, IHC, IP, ELISA |
| CSB-PA000485 | Phospho-BCL2 (T56) Antibody | Human | WB, IHC, IP, IF, ELISA |
| CSB-PA000982 | BCL2 Antibody | Human,Monkey | WB, IHC, ELISA |
| CSB-PA000983 | BCL2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA000984 | BCL2 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA040190 | Phospho-BCL2 (T69) Antibody | Human | IHC, IF, ELISA |
| CSB-PA040191 | Phospho-BCL2 (S87) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA040192 | Phospho-BCL2 (T74) Antibody | Human | IHC, ELISA |
| CSB-PA597947 | BCL2 Antibody | Human | ELISA,WB |
| CSB-PA832691 | BCL2 Antibody | Human | ELISA,WB,IHC |
| CSB-PA703826 | BCL2 Antibody | Mouse,Rat | WB,ELISA |
| CSB-PA12959A0Rb | BCL2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA12959B0Rb | BCL2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA12959C0Rb | BCL2 Antibody, FITC conjugated | Human | |
| CSB-PA12959D0Rb | BCL2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA002611A0HU | BCL2 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, IHC, FC |
| CSB-RA564360A0HU | BCL2 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-MA002611A0m | BCL2 Monoclonal Antibody | Human, Mouse | ELISA, WB, FC |
Bcl2 for H, M, R
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-MA000196 | BCL2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
Bcl2 Proteins
Bcl2 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP002611CH1 CSB-EP002611CH1 CSB-BP002611CH1 CSB-MP002611CH1 CSB-EP002611CH1-B |
Recombinant Chicken Apoptosis regulator Bcl-2 (BCL2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002611CH | Recombinant Chicken Apoptosis regulator Bcl-2 (BCL2) | in vitro E.coli expression system |
Bcl2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP002611HU1 CSB-BP002611HU1 CSB-MP002611HU1 CSB-EP002611HU1-B |
Recombinant Human Apoptosis regulator Bcl-2 (BCL2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002611HU | Recombinant Human Apoptosis regulator Bcl-2 (BCL2) | in vitro E.coli expression system |
| CSB-EP002611HU1 | Recombinant Human Apoptosis regulator Bcl-2 (BCL2), partial | E.coli |
Bcl2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP002611MO CSB-BP002611MO CSB-MP002611MO CSB-EP002611MO-B |
Recombinant Mouse Apoptosis regulator Bcl-2 (Bcl2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002611MO | Recombinant Mouse Apoptosis regulator Bcl-2 (Bcl2), partial | E.coli |
| CSB-CF002611MO(A4) | Recombinant Mouse Apoptosis regulator Bcl-2 (Bcl2) | in vitro E.coli expression system |
Bcl2 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP002611RA1 CSB-EP002611RA1 CSB-BP002611RA1 CSB-MP002611RA1 CSB-EP002611RA1-B |
Recombinant Rat Apoptosis regulator Bcl-2 (Bcl2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Bcl2 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP002611BO1 CSB-EP002611BO1 CSB-BP002611BO1 CSB-MP002611BO1 CSB-EP002611BO1-B |
Recombinant Bovine Apoptosis regulator Bcl-2 (BCL2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002611BO | Recombinant Bovine Apoptosis regulator Bcl-2 (BCL2) | in vitro E.coli expression system |
Bcl2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP744176DO1 CSB-EP744176DO1 CSB-BP744176DO1 CSB-MP744176DO1 CSB-EP744176DO1-B |
Recombinant Dog Apoptosis regulator Bcl-2 (BCL2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Bcl2 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP872860DXU1 CSB-EP872860DXU1 CSB-BP872860DXU1 CSB-MP872860DXU1 CSB-EP872860DXU1-B |
Recombinant Cricetulus griseus Apoptosis regulator Bcl-2 (BCL2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF872860DXU | Recombinant Cricetulus griseus Apoptosis regulator Bcl-2 (BCL2) | in vitro E.coli expression system |
Bcl2 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-CF744176DO | Recombinant Dog Apoptosis regulator Bcl-2 (BCL2) | in vitro E.coli expression system |
Bcl2 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-CF002611RA | Recombinant Rat Apoptosis regulator Bcl-2 (Bcl2) | in vitro E.coli expression system |
Bcl2 ELISA Kit
Bcl2 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E08853h | Human B-cell leukemia/lymphoma 2,Bcl-2 ELISA Kit | serum, plasma, tissue homogenates | 0.225 ng/mL |
Bcl2 ELISA Kit for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E08855m | Mouse B-cell leukemia/lymphoma 2,Bcl-2 ELISA Kit | serum, plasma | 3.9 pg/mL |
Bcl2 ELISA Kit for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E08854r | Rat B-cell CLL/lymphoma 2 (BCL2) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
