BAFF
BAFF(B细胞激活因子)是一种由髓系细胞产生的细胞因子,属于肿瘤坏死因子家族,对B细胞的存活、增殖、抗原呈递以及类别转换重组起着至关重要的作用。它通过与三种受体(TNFRSF13B/TACI、TNFRSF17/BCMA、TNFRSF13C/BAFFR)结合,激活多种信号通路,包括NF-κB、MAPK(丝裂原活化蛋白激酶)和PI3K/AKT等,这些信号通路在B细胞的生物学过程以及免疫调节中发挥着重要作用。然而,BAFF的过度产生和激活也可能导致自身免疫性疾病的发生。因此,对BAFF的结构功能及其参与的信号通路的深入研究,对于理解其在免疫系统中的作用机制以及开发相关疾病的治疗方法具有重要意义。
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验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B at 10 μg/ml can bind human BCMA (CSB-MP023974HU1), the EC50 of human TNFSF13B protein is 221.3-298.6 ng/ml.
Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
Activity
Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B at 2 μg/ml can bind TNFRSF13C(CSB-MP853495HU1), the EC50 is 9.943-15.72 ng/ml.
The purity of TNFSF13B was greater than 90% as determined by SEC-HPLC
BAFF Antibodies
BAFF for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA023990GA01HU | TNFSF13B Antibody | Human | ELISA,WB |
CSB-PA05767A0Rb | TNFSF13B Antibody | Human | ELISA |
CSB-PA897523ESR2HU | TNFSF13B Antibody | Human, Mouse | ELISA, WB, IHC |
CSB-PA005018 | TNFSF13B Antibody | Human,Mouse | WB, ELISA |
CSB-PA981923 | TNFSF13B Antibody | Human | ELISA,WB,IHC |
CSB-PA108957 | TNFSF13B Antibody | Human | ELISA,IHC |
BAFF Proteins
BAFF Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP897523HU CSB-BP897523HU CSB-MP897523HU CSB-EP897523HU-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP897523HU | Recombinant Human Tumor necrosis factor ligand superfamily member 13B protein (TNFSF13B), partial | E.coli |
CSB-AP002191HU | Recombinant Human Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), partial (Active) | E.Coli |
CSB-MP897523HU1 | Recombinant Human Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), partial (Active) | Mammalian cell |
CSB-MP897523HU1-B | Recombinant Human Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), partial,Biotinylated (Active) | Mammalian cell |
BAFF ELISA Kit
BAFF ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-E11912h | Human B cell activation factor,BAFF ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |