Ackr2

ACKR2是一个编码β趋化因子受体的基因，预测该蛋白质是与G蛋白偶联受体类似的七次跨膜蛋白。该蛋白质在多种组织和造血细胞中表达。该受体在淋巴内皮细胞中的表达，以及在血管肿瘤中的过度表达，表明了它在趋化因子驱动的白细胞再循环和可能影响血管肿瘤发展和生长的趋化因子作用中的功能。新兴证据表明，该蛋白质在银屑病患者的炎症变化中起着分子调节器的作用。
ACKR2 is a gene encoding a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. Emerging evidence has demonstrated that this protein plays a role in inflammatory changes in patients with psoriasis as a molecular regulator.