ATR
ATR，即共济失调毛细血管扩张和辐射敏感综合征相关蛋白，也称为共济失调毛细血管扩张突变蛋白。它是一种在细胞周期中起关键作用的蛋白质激酶，主要在细胞核中表达。ATR的作用机制是通过感知DNA复制过程中的异常，如单链DNA（ssDNA）的产生，进而激活多个下游信号通路，包括CHK1和CHK2等。这些信号通路参与细胞周期的检查点控制，确保DNA复制的准确性和完整性。在信号传导过程中，ATR通过磷酸化多种底物蛋白，促进细胞周期停滞，DNA修复，以及对复制压力的响应。ATR对维持基因组稳定性至关重要，其功能异常与多种疾病有关，包括癌症、遗传性疾病和衰老。ATR的激活有助于防止细胞因DNA损伤而发生癌变，是细胞应对DNA损伤的重要机制之一。
热销产品
ATR Antibody (CSB-PA622666LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA622666LA01HU at dilution of 1:100
Western Blot
Positive WB detected in: Raji whole cell lysate, K562 whole cell lysate
All lanes: ATR antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 302, 295, 298 kDa
Observed band size: 302 kDa
ATR Antibodies
ATR for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA002433GA01HU | ATR Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA267100 | ATR (Ab-428) Antibody | Human | ELISA,IHC |
| CSB-PA058282 | Phospho-ATR (Ser428) Antibody | Human | ELISA,IHC |
| CSB-PA030127 | Phospho-ATR (S428) Antibody | Human | IHC, ELISA |
| CSB-PA030128 | ATR Antibody | Human | WB, IHC, ELISA |
| CSB-PA622666LA01HU | ATR Antibody | Human | ELISA, WB, IHC |
| CSB-PA622666LD01HU | ATR Antibody, Biotin conjugated | Human | ELISA |
ATR Proteins
ATR Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP622666HU CSB-EP622666HU CSB-BP622666HU CSB-MP622666HU CSB-EP622666HU-B |
Recombinant Human Serine/threonine-protein kinase ATR (ATR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATR Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP863791DOA CSB-EP863791DOA CSB-BP863791DOA CSB-MP863791DOA CSB-EP863791DOA-B |
Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR (ATR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATR Proteins for Xenopus laevis (African clawed frog)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP872068XBE CSB-EP872068XBE CSB-BP872068XBE CSB-MP872068XBE CSB-EP872068XBE-B |
Recombinant Xenopus laevis Serine/threonine-protein kinase atr (atr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATR Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP872870MO CSB-EP872870MO CSB-BP872870MO CSB-MP872870MO CSB-EP872870MO-B |
Recombinant Mouse Serine/threonine-protein kinase ATR (Atr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
