Recombinant Human Toll-like receptor 8 (TLR8), partial

1. Conditioned media or microparticles released from obese omental adipose tissue increased CD16 and CCR5 expression on CD14(+)CD16(-) monocytes and augmented their migratory capacity towards the conditioned media from obese omental adipose tissue, itself. PMID: 27677832
2. MBZ-induced IL-1beta release was found to be dependent on NLRP3 inflammasome activation and to involve TLR8 stimulation. PMID: 28472897
3. the current study shows that motolimod ( selective small-molecule agonist of TLR8, stimulates natural killer (NK) cells, dendritic cells, and monocytes))can be safely administered in combination with cetuximab with an acceptable toxicity profile PMID: 27810904
4. Epstein-Barr virus (EBV) replication activating the toll like receptor 8 (TLR8) molecular pathway in primary monocytes. PMID: 28245863
5. this study identified TLR8 as mediator of monocyte differentiation and M2 macrophage polarization during hepatitis C virus infection PMID: 28122964
6. Demonstrate STAT1-dependent transcriptional activation of TLR8 with estrogen stimulation. PMID: 28039018
7. TLR8 gene rs3764880 polymorphisms might be associated with susceptibility to ischemic stroke and involved in the inflammatory reaction and lipid metabolism of ischemic stroke in southern Chinese Han. PMID: 27772795
8. this study shows that TLR8 gene polymorphism is associated with susceptibility to HIV and HCV co-infection PMID: 28062211
9. Comparison of present and previous association studies reveals contradictory results for common variants. Thus, no associations exist between genetic variation in TLR8 and AR. PMID: 26556310
10. Identified human TLR8 as functional TLR13 equivalent that promiscuously senses ssRNA. PMID: 26545385
11. TLR8 polymorphisms seem to be related to non-progression of liver fibrosis in HIV/HCV coinfected patients, particularly in males and those patients infected with GT1. PMID: 26455634
12. TLR8 with the uncleaved Z-loop is unable to form a dimer. The uncleaved Z-loop located on the ascending lateral face prevents the approach of the dimerization partner by steric hindrance. PMID: 26929371
13. Sex-specific associations for TLR8 polymorphisms in tuberculosis. PMID: 26160538
14. Knockdown of LRRC59 reduced TLR3-, 8-, and 9-mediated, but not TLR4-mediated, signaling. PMID: 26466955
15. the activation of TLR8 by bi-specific si-RNA for the production of INFbeta, was investigated. PMID: 26202481
16. Results suggest a relationship between the TLR8 and the susceptibility to Crohn's disease and Behcet's disease. PMID: 26486764
17. Carriage of the G-allele of TLR8-rs3764879 was associated with the occurrence of SLE in Danish women, but not men. PMID: 24919757
18. TLR8 is identified as receptor for bacterial RNA in primary human monocyte-derived macrophages. Moreover, TLR8-dependent detection of bacterial RNA was critical for triggering monocyte activation in response to infection with Streptococcus pyogenes. PMID: 26101323
19. This study demonstrates a physiological role of TLR8 in the sensing of entire S. aureus in human primary phagocytes, including the induction of IFN-beta and IL-12 production via a TAK1-IKKbeta-IRF5 pathway that can be inhibited by TLR2 signaling. PMID: 26085680
20. No significant associations have been found between TLR8 polymorphisms and susceptibility to Graves' disease in Chinese Cantonese. PMID: 25430040
21. Met1Val of TLR8 is significantly associated with risk of pulmonary tuberculosis susceptibility in southern Punjab population. This effect was highly pronounced among males. PMID: 25572425
22. The minor allele of TLR8 rs3764879 of the donor is associated with outcome after myeloablative conditioned allogeneic hematopoietic cell transplantation. PMID: 25464115
23. TLR8, but not TLR7, is involved in priming of human neutrophil reactive oxygen species production by inducing the phosphorylation of p47phox and p38 MAPK. PMID: 25877926
24. Increased miR-K-10b and miR-K12-12 are functionally involved in sepsis as agonists of TLR8, forming a positive feedback that may lead to cytokine dysregulation. PMID: 25476907
25. Data show that activation of toll-like receptor 8 (TLR8) signaling in tumor cells can block the induction and reverse the suppression of senescent naive and tumor-specific T cells in vitro and in vivo, resulting in enhanced anti-tumor immunity. PMID: 25231413
26. Data indicate that treatment with toll-like receptor 8 (TLR8) agonists elicited granzyme B production. PMID: 25667415
27. TLR8 activation has direct anti-leukemic effects independent of its immunomodulating properties. PMID: 25283842
28. The insertion loop between leucine-rich repeats 14 and 15 in TLR8 is indispensable for the receptor cleavage in endosomes. PMID: 25297876
29. HIV-1 infection induced the expression of pro-IL-1beta via TLR8-mediated mechanisms and activated caspase-1 through the NLRP3 inflammasome to cleave pro-IL-1beta into bioactive IL-1beta PMID: 24939850
30. The mRNA expression level of TLR8 in the patients with cervical cancer and Hela cells were up-regulated, it consistent with the increased expression of VEGF and Bcl-2. PMID: 24782650
31. Data indicate 4-methyl-1-pentyl-1H-benzo[d]imidazol-2-amine a pure toll-like receptor 8 (TLR8) agonist, evoking proinflammatory cytokine and Type II interferon responses in mononuclear leukocytes. PMID: 25102141
32. non-synonymous TLR8 SNP rs3764880-G allele was a risk factor for oral ulcer and pericardial effusion, with significant additive effects PMID: 24445780
33. Variations in TLR8 genes may modulate immune responses during HCV infection. PMID: 24205871
34. TLR8 is a novel estrogen target gene that can lower the inflammatory threshold and implicate an IFNalpha-independent inflammatory mechanism that could contribute to higher systemic lupus erythematosus incidence in women. PMID: 24525049
35. The mechanisms of action of Aldaratrade mark are complex. Imiquimod is an effective ligand for TLR7 (and TLR8 in humans) and also interferes with adenosine receptor signaling. PMID: 24254490
36. Bb RNA is a TLR8 ligand in human monocytes and that transcription of IFN-beta in response to the spirochete is induced from within the phagosomal vacuole through the TLR8-MyD88 pathway. PMID: 23906644
37. Data indicate that TLR8 stimulation of NK-DC co-cultures significantly increased DC priming of EGFR-specific CD8(+) T cells in the presence of cetuximab. PMID: 23685782
38. TLR8 expression and signaling is impaired in peripheral blood mononuclear cells from patients with multiple sclerosis PMID: 23787171
39. This study demonstrates profibrotic properties of circulating monocytes from patients with systemic sclerosis and a key role for TLR signalling, particularly TLR8, in TIMP-1 secretion and matrix remodelling. PMID: 23223421
40. crystal structures of unliganded and ligand-induced activated TLR8 dimers were elucidated; ligand binding induces reorganization of the TLR8 dimer, which enables downstream signaling processes PMID: 23520111
41. Single nucleotide polymorphism in the TLR8 gene is associated with allergic rhinitis. PMID: 22857391
42. IL10 production after TLR9 ligands or HSV-1 stimulation was significantly related with plasma levels of sex hormones, whereas no correlation was found in cytokines produced following TLR7 and TLR8 stimulation. PMID: 22768144
43. Expression of TLR8 is significantly increased in HeLa cells. TLR8 agonist may influence tumor development. PMID: 22340042
44. UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling PMID: 22164301
45. Epigenetic regulation of tumor necrosis factor alpha (TNFalpha) release in human macrophages by HIV-1 single-stranded RNA (ssRNA) is dependent on TLR8 signaling PMID: 22393042
46. analyzed the frequency of TLR7 rs179008, TLR8 rs3764880, TLR9 rs5743836 and rs352140 in 370 patients with SLE and 415 healthy controls from southern Brazil PMID: 22065095
47. Human TLR8 detectS viral single-stranded RNA and imidazoquinoline compounds. Review. PMID: 22289837
48. Quantitative polymerase chain reaction showed significantly higher expression of LEAP-1 (P = 0.002) and TLR-8 (P = 0.023) and TLR-10 (P = 0.014) in viral keratitis and LEAP-2 (P = 0.034) in dry eye, versus controls. PMID: 21499082
49. Lower toll-like receptor 8 expression was observed in monocytes from infants with respiratory syncytial virus infection. PMID: 20946625
50. Phagosomal signaling involves a cooperative interaction between TLR2 and TLR8 in pro- and antiinflammatory cytokine responses, whereas TLR8 is solely responsible for IRF7-mediated induction of IFN-beta. PMID: 21321205

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HGNC: 15632

OMIM: 300366

KEGG: hsa:51311

STRING: 9606.ENSP00000218032

UniGene: Hs.660543