Human Selenoprotein S(SELS) ELISA kit

Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.

1. In these studies found that SelS increases in negative correlation with tau phosphorylation in brain. PMID: 27802219
2. The results suggest that SelS is required for C99 degradation through endoplasmic reticulum-associated degradation, resulting in inhibition of amyloid beta production. PMID: 28315680
3. regulating liver and serum Selenoprotein S levels might become a new strategy for the prevention and treatment of DM and its macrovascular complications PMID: 27121097
4. SEPS1 may be a potential gene marker for disease diagnosis and prognosis. PMID: 26382012
5. interaction between SelK and p97(VCP) is SelS-dependent, and the resulting ERAD complex (SelS-p97(VCP)-SelK) plays an important role in ERAD and ER stress PMID: 26504085
6. Potential roles of the SEPS1 gene in the pathogenesis and etiology of Hashimoto's thyroiditis. PMID: 26016409
7. SNP rs4965814 of SELS may affect the susceptibility to ischemic stroke. PMID: 25390504
8. The SEPS1 -105G>A is associated with an increased risk of Kashin-Beck disease and influences the expression of PI3K/Akt signaling pathway in Kashin-Beck disease patients PMID: 25433273
9. Although VIMP can interact with CLIMP-63 and Syn5L, it does not interact with MT-binding ER proteins (such as Reep1) that shape the tubular smooth ER PMID: 25008318
10. Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells in inflammatory bowel diseases. PMID: 24275540
11. Pro(178) and Pro(183) of SelS play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress PMID: 24700463
12. that SEPS1 may protect mice against LPS-induced sepsis and organ damage. Therefore, SEPS1 may be a new target to resolve LPS-induced sepsis. PMID: 24573439
13. Existence of a link between SEPS1 promoter genetic variation and Hashimoto thyroiditis risk. PMID: 24471570
14. Findings suggest that the SEPS1 G-105A polymorphism contributes to the risk of developing SPTB in a Chinese population. PMID: 23776519
15. Our results indicated that the rs12910524 in the Tanis gene was associated with triglyceride concentrations in subjects without diabetes in China. PMID: 23829426
16. Data suggest that selenocysteine allows selenoprotein S (SelS, VIMP) to sustain activity under oxidative stress. PMID: 23914919
17. These results suggest a potential role for the SELS region in the development subclinical cardiovascular disease in this sample enriched for type 2 diabetes mellitus. PMID: 23161441
18. the redox properties observed for recombinant VIMP are compatible with a function as a reductase PMID: 22700979
19. Upregulation of SelS expression in reactive astrocytes reveals a new protective role for SelS against inflammation and endoplasmic reticulum stress that can be relevant to astrocyte function. PMID: 21456042
20. a role for SELS in the development of metabolic disease, especially in the context of insulin resistance. PMID: 20619427
21. beta-ME, also an ER stress agent, could induce cell apoptosis, and SelS may play an important role in protecting cells from apoptosis induced by ER stress in HepG2 cells. PMID: 20114070
22. SELS is regulated by glucose deprivation and endoplasmic reticulum stress. It is a glucose-regulated protein. PMID: 15063746
23. Positive relationship between Tanis mRNA and the acute-phase protein serum amyloid A suggests an interaction between innate immune system responses and Tanis expression in muscle and adipose tissue. PMID: 15161744
24. Derlin-1 interacts with US11, a virally encoded ER protein that specifically targets MHC class I heavy chains for export from the ER, as well as with VIMP, a novel membrane protein that recruits the p97 ATPase and its cofactor PMID: 15215856
25. SEPS1 may regulate cytokine production in macrophage cells and there may be a regulatory loop between TNF-alpha, IL-1beta and SEPS1 that plays a key role in control of the inflammatory response PMID: 16574427
26. SEPS1 protein is secreted from hepatoma cells. Fractionation of human serum indicated that SEPS1 was associated with LDL and possibly with VLDL. PMID: 17374524
27. significant association with increased CHD risk in females carrying the minor allele of rs8025174. Another variant, rs7178239, increased the risk for ischemic stroke significantly in females. PMID: 17641917
28. -105G>A polymorphism is not associated with IBD susceptibility and does not contribute to a certain disease phenotype or increased TNF-alpha levels in IBD patients. PMID: 17661913
29. Selenoprotein S -105(adenosine) allele is a non-significant risk factor in young stroke patients from Italy and Germany. PMID: 17880573
30. Six polymorphisms were studied in this gene, and none are associated with type 1 diabetes, rheumatoid arthritis or inflammatory bowel diseases. PMID: 18625033
31. SelS has a role in lipopolysaccharide-induced inflammatory response in hepatoma HepG2 cells PMID: 18675776
32. SelS protein may be involved in insulin resistance in Chinese with type 2 diabetes mellitus (T2DM) by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis PMID: 18710632
33. The -105G>A promoter polymorphism of SEPS1 was associated with the intestinal type of gastric cancer. PMID: 19144102
34. Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency. PMID: 19398551
35. Regulatory variant in SELS influences inflammatory response to ER stress PMID: 16227999

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Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm.

Selenoprotein S family

HGNC: 30396

OMIM: 607918

KEGG: hsa:55829

STRING: 9606.ENSP00000381282

UniGene: Hs.32148