Your Good Partner in Biology Research

  1. 首页
  2. 产品中心
  3. 蛋白
  4. 跨膜蛋白
  5. 人白细胞抗原

跨膜蛋白系列四：人白细胞抗原（HLA）

什么是人类白细胞抗原？

跨膜蛋白跨越膜磷脂双层，这决定了跨膜域的强疏水性。跨膜蛋白的跨膜域可完全或部分插入膜内。跨膜蛋白种类的多样性决定了其功能特点的多样性。它具有物质转运、信号转导能力。此外，在免疫应答中，跨膜蛋白也发挥及其重要的作用。

人白细胞抗原（Human leukocyte antigen, HLA）是一类跨膜蛋白，是存在于机体细胞表面的一种蛋白或抗原，在机体免疫防御中起着至关重要的作用。HLA系统和MHC一起帮助身体的免疫系统区分自体物质和外来物质。

人白细胞抗原（HLA）在人群中的分布

HLA抗原在不同地区有不同的分布。以HLA-B*27为例，在美国哥伦比亚、加拿大沿海印第安人和加拿大海达人中，其阳性率高达50%；在欧洲和美国的白种人中，B27阳性率为6%到8%；日本和非洲黑人的B27阳性率低于1%。

人白细胞抗原（HLA）应用

HLA主要应用于器官移植和输血中供体和受体的匹配。

在器官移植中，供体和受体必须具有相同或匹配的HLA基因，以使供体组织不受受体免疫系统的攻击或排斥。

在临床输血中，异体HLA免疫在输血治疗中引起各种问题，如血小板输注不应性，发热引起的非溶血性输血反应，输血相关的急性肺损伤，输血相关的移植物抗宿主病等。因此，HLA检测是非常必要的。

人白细胞抗原（HLA）和疾病

HLA基因与自身免疫疾病和癌症有关。

HLA基因 相关疾病
HLA-B 强直性脊柱炎
HLA-DRB1 类风湿性关节炎
HLA-A1、B8、DR17 自体免疫疾病
HLA-DR3 1型糖尿病

许多研究表明，HLA与HIV疾病有关。此外，HLA与妊娠期间复发性流产，先兆子痫或新生儿溶血性疾病密切相关。HLA也是药物敏感性的原因之一。

更多细节了解，如抗原处理途径、人群分布、HLA多态性等，扩展阅读：Human Leukocyte Antigen: Distinguish between Friend and Foe.

在您的实验中，您可能需要HLA产品来辅助您的研究。CUSABIO可以帮助您。我们已经建立了一个特殊的跨膜蛋白表达系统。目前已生产HLA相关产品如下：

Human leukocyte antigen (HLA) related proteins for your research

Target Product Name Code Expression System
HLA-B Recombinant Human HLA-B protein(HLA-B),partial CSB-RP150894h E.coli
HLA-C Recombinant Human HLA-C protein(HLA-C),partial CSB-RP150994h E.coli
HLA-DRA Recombinant Human HLA class II histocompatibility antigen, DR alpha chain(HLA-DRA)，partial CSB-EP360793HU1 E.coli
HLA-DQA1 Recombinant Human HLA class II histocompatibility antigen, DQ alpha 1 chain(HLA-DQA1),partial CSB-RP148394h E.coli
HLA-DQA2 Recombinant Human HLA class II histocompatibility antigen, DQ alpha 2 chain(HLA-DQA2),partial CSB-RP148294h E.coli
HLA-DPA1 Recombinant Human HLA class II histocompatibility antigen, DP alpha 1 chain(HLA-DPA1),partial CSB-RP148194h E.coli
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G) CSB-MP010509HU Mammalian cell
HLA-DPB1 Recombinant Human HLA class II histocompatibility antigen, DP beta 1 chain(HLA-DPB1),partial CSB-RP148094h E.coli
HLA-DRB1 Recombinant Human HLA class II histocompatibility antigen, DRB1-1 beta chain(HLA-DRB1),partial CSB-EP361230HU E.coli
HLA-DRA Recombinant Human HLA class II histocompatibility antigen, DR alpha chain(HLA-DRA) CSB-EP360793HU E.coli
HLA-DQB1 Recombinant Human HLA class II histocompatibility antigen,DQ beta 1 chain(HLA-DQB1),partial CSB-EP355782HU E.coli
HLA-DMA Recombinant Human HLA-DMA protein(HLA-DMA),partial CSB-EP338892HU E.coli
HLA-DMB Recombinant Human HLA class II histocompatibility antigen, DM beta chain(HLA-DMB),partial CSB-EP333326HU E.coli
HLA-A Recombinant Human HLA class I histocompatibility antigen,A-1 alpha chain(HLA-A),partial CSB-EP328989HU E.coli
HLA-E Recombinant Human HLA class I histocompatibility antigen, alpha chain E(HLA-E) ,partial CSB-EP320269HU E.coli
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G) CSB-EP010509HUb0 E.coli
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G) CSB-EP010509HUa2 E.coli
HLA-DRA Recombinant Human HLA class II histocompatibility antigen, DR alpha chain(HLA-DRA) CSB-YP360793HU Yeast
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G),partial CSB-EP010509HU1 E.coli
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G) CSB-EP010509HU E.coli
HLA-E Recombinant Human HLA class I histocompatibility antigen, alpha chain E(HLA-E),partial CSB-BP320269HU Baculovirus
HLA-A Recombinant Human HLA class I histocompatibility antigen,A-1 alpha chain(HLA-A),partial CSB-EP328989HUb1 E.coli
HLA-A Recombinant Human HLA class I histocompatibility antigen, A alpha chain(HLA-A),partial CSB-BP328989HU Baculovirus
HLA-A Recombinant Human HLA class I histocompatibility antigen, A alpha chain(HLA-A),partial CSB-EP3499HU E.coli
HLA-DRB1 Recombinant Human HLA class II histocompatibility antigen, DRB1-3 chain(HLA-DRB1),partial CSB-EP365687HU E.coli
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G),partial CSB-EP010509HU1a6 E.coli
HLA-DRB5 Recombinant Human HLA class II histocompatibility antigen, DR beta 5 chain(HLA-DRB5),partial CSB-EP657235HU E.coli
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G) CSB-YP010509HU Yeast
HLA-DRB1 Recombinant Human HLA class II histocompatibility antigen, DRB1-12 beta chain(HLA-DRB1) CSB-EP846484HU E.coli

Human leukocyte antigen (HLA) related antibodies for your research

Target Product Name Code Species Reactivity Tested Applications
HLA-H HLA-H Antibody CSB-PA958630 Human ELISA, WB
HLA-H HLA-H Antibody CSB-PA009213 Human ELISA, WB
HLA-DQB1/HLA-DQB2 HLA-DQB1/HLA-DQB2 Antibody CSB-PA005915 Human ELISA, WB
HLA-DPA1 HLA-DPA1 Antibody CSB-PA14819A0Rb Human ELISA, WB, IF
HLA-DPA1 HLA-DPA1 Antibody CSB-PA177845 Human ELISA, WB
HLA-DOB HLA-DOB Antibody CSB-PA002935 Human ELISA, WB
HLA-DPA1 HLA-DPA1 Antibody CSB-PA009209 Human ELISA, WB
HLA-DOB HLA-DOB Antibody CSB-PA270928 Human ELISA, WB
HLA-A HLA-A Antibody CSB-PA906516 Human ELISA, WB
HLA-A HLA-A Antibody CSB-PA398166 Human ELISA, WB
HLA-DMB HLA-DMB Antibody CSB-PA561724 Human ELISA, IHC
HLA-DOA HLA-DOA Antibody CSB-PA002934 Human WB, IHC, ELISA
HLA-DOA HLA-DOA Antibody CSB-PA113671 Human ELISA, WB
HLA-DOA HLA-DOA Antibody CSB-PA356784ESR1HU Human ELISA, IHC

Human leukocyte antigen (HLA) related ELISA kits for your research

Target Product Name Code Sample Type Sensitivity
HLA-DRA Human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) ELISA kit CSB-EL010497HU serum, plasma, tissue homogenates 4.68 pg/mL
HLA-G Human leukocyte antigen G,HLA-G ELISA Kit CSB-E09401h serum, plasma, tissue homogenates 0.31 ng/mL
HLA-B27 Human leucocyte antigen B27,HLA-B27 ELISA Kit CSB-E08607h serum, urine, cerebrospinal fluid (CSF) 0.078 ng/mL
HLA-E Human major histocompatibility complex, class I, E (HLA-E) ELISA kit CSB-EL010507HU serum, plasma, cell culture supernates, tissue homogenates 7.81 pg/mL