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  4. Recombinant Sheep Melatonin receptor type 1A (MTNR1A)

Recombinant Sheep Melatonin receptor type 1A (MTNR1A)

  • 货号：
    CSB-CF015189SH
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    MTNR1A; Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor
  • 种属：
    Ovis aries (Sheep)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-366
  • 氨基酸序列
    MAGRLWGSPGGTPKGNGSSALLNVSQAAPGAGDGVRPRPSWLAATLASILIFTIVVDIVG NLLVVLSVYRNKKLRNAGNVFVVSLAVADLLVAVYPYPLALASIVNNGWSLSSLHCQLSG FLMGLSVIGSVFSITGIAINRYCCICHSLRYGKLYSGTNSLCYVFLIWTLTLVAIVPNLC VGTLQYDPRIYSCTFTQSVSSAYTIAVVVFHFIVPMLVVVFCYLRIWALVLQVRWKVKPD NKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLVVASDPASMAPRIPEWLFVASYYMA YFNSCLNAIIYGLLNQNFRQEYRKIIVSLCTTKMFFVDSSNHVADRIKRKPSPLIANHNL IKVDSV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
  • 基因功能参考文献：
    1. This study demonstrated that the T allele in the SNP rs403212791 in the MNTR1A gene is associated with a lower total days of anestrus and higher progesterone cycling months and estrus cycling months values in the Rasa Aragonesa breed. PMID: 29475126
    2. Data suggest a positive effect of melatonin treatment on the time of first conception in ewe lambs in Sardinia. The G/G genotype of an SNP in Mtnr1a (G612A; melatonin receptor 1A) influences the reproductive response to melatonin treatment; no influence was found for an SNP in KiSS1 (G1035A; kisspeptin-1) or another SNP in Mtnr1a (C606T). PMID: 25375207
    3. The frequency of single nucleotide polymorphisms of MTNR1A in tropical and temperate climate sheep breeds is reported. PMID: 25708518
    4. The data revealed that the MTNR1A gene polymorphisms influenced spring reproductive resumption in the Sarda sheep breed. PMID: 25132211
    5. Haplotype with T, A and T alleles for SNPs 422, 677 (promoter region) and 612 (Exon 2) showed an increase of the percentage of oestrous cyclic ewes. PMID: 22809454
    6. Report the presence of MT(1) and MT(2) receptors in ram spermatozoa. PMID: 22935156
    7. there was a positive correlation between melatonin receptor type 1A (MTNR1A) allele polymorphisms the reproductive response following synchronisation and artificial insemination in the spring PMID: 21211471
    8. MTNR1A transcripts are expressed in the ovine premammillary hypothalamus and their expression follows a diurnal rhythm PMID: 15470001
    9. The current data, on the MT(1) promoter suggests a general model in which melatonin receptor expression in the mammalian pituitary is determined by the balance between stimulatory and inhibitory transcription factors. PMID: 17337323
    10. Polymorphism of the MTNR1A locus is present in the Sarda sheep breed with a high incidence of the C/C genotype. PMID: 19223130
    11. Ewes with at least 1 M allele are able to conceive at younger ages, better able to breed and conceive out-of-season, and have shorter intervals between first and second lambings than ewes expressing only the m allele. PMID: 19359514

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: oas:443022

    UniGene: Oar.506