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  4. Recombinant Rat Zinc transporter 1 (Slc30a1)

Recombinant Rat Zinc transporter 1 (Slc30a1)

  • 中文名称：
    大鼠Slc30a1重组蛋白
  • 货号：
    CSB-CF723471RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Slc30a1
  • Uniprot No.：
  • 别名：
    Slc30a1; Znt1; Zinc transporter 1; ZnT-1; Solute carrier family 30 member 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    329-507
  • 氨基酸序列
    YTTYPLLKESALILLQTVPKQIDIKHLVKELRDVEGVEEVHELHVWQLAGSRIIATAHIK CEDPASYMQVAKTIKDVFHNHGIHATTIQPEFASVGSKSSVVPCELACRTQCALKQCCGT RPQVHSGKEAEKAPTVSISCLELSENLEKKPRRTKAEGSVPAVVIEIKNVPNKQPESSL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in zinc transport out of the cell.
  • 基因功能参考文献：
    1. Hypoxia/reoxygenation dramatically decreased ZnT-1 expression in rat astrocytes. PMID: 26463958
    2. These data indicate that maternal zinc deficiency resulted in an elevated incidence of fetal heart malformations, which was associated with significant decreases in placental MT-1 and ZnT-1 mRNA expressions PMID: 24807795
    3. ZNT-1 interacts with GluN2A-containing NMDA receptors at the glutamatergic synapse. This complex is regulated by synaptic plasticity induction. ZNT-1 expression modulation in hippocampal neurons shrank dendritic spines and reduced GluN2A surface levels. PMID: 25319628
    4. The mRNA levels of ZnT-1 and BDNF were significantly increased in spinal cord injury model group. PMID: 20838921
    5. ZnT-1 expression is crucial for maintaining zinc homeostasis, in particular, for the enhanced retention of zinc in transformed cells when subjected to zinc deprivation. PMID: 21775119
    6. These data are consistent with an important role for ZnT-1, ZnT-3 and PRG-1 in the pathophysiology of the long-term adverse effects of recurrent neonatal seizure-induced hippocampal mossy fiber sprouting and cognitive deficit. PMID: 20167268
    7. show that rapid electrical pacing can augment ZnT-1 expression in culture as well as in the atria of rats in vivo. PMID: 20201890
    8. The elevated ZnT-1 expression following zinc priming or after heterologous expression of ZnT-1 may explain the reduced zinc accumulation and the subsequent reduction in sensitivity toward toxic zinc levels. [ZnT-1] PMID: 15378655
    9. Our findings therefore indicate that ZnT-1 modulates the permeation of cations through LTCC, thereby, regulating cation homeostasis through this pathway. PMID: 15451416
    10. Zn deficiency results in alterations in Zn transporter expression, which facilitates increased brain Zn uptake and results in the conservation of brain Zn during Zn deficiency PMID: 15867272
    11. These results indicate that endogenously-expressed ZnT-1, by modulating LTCC, has a dual role: regulating calcium influx, and attenuating Cd(2+) and Zn(2+) permeation and toxicity in neurons and other cell types. PMID: 16741752
    12. findings demonstrate that crosstalk between ZnT-1 and the L-type calcium channels may underlie atrial response to rapid pacing, suggesting that ZnT-1 is a significant participant in rate-dependent cardiac electrical remodeling. PMID: 17196651
    13. ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats. PMID: 19059322
    14. findings suggest that ZnT1 plays a direct role in Zn2+ efflux in cultured cortical neurons PMID: 19095042
    15. zinc transporter 1 is an endogenous inhibitor of L-type calcium channels PMID: 19767393

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Localized on the basolateral surface of the enterocytes.
  • 蛋白家族：
    Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
  • 组织特异性：
    Widely expressed. The protein is detected in duodenum and jejunum but not in ileum and colon.
  • 数据库链接：

    KEGG: rno:58976

    STRING: 10116.ENSRNOP00000006340

    UniGene: Rn.10120