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  4. Recombinant Rat Synaptophysin (Syp)

Recombinant Rat Synaptophysin (Syp)

In Stock
  • 货号：
    CSB-CF023024RA
  • 规格：
    ￥9720
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Syp
  • Uniprot No.：
  • 别名：
    (Major synaptic vesicle protein p38)
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length
  • 来源：
    in vitro E.coli expression system
  • 分子量：
    34.8 kDa
  • 表达区域：
    1-307aa
  • 氨基酸序列
    MDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVEFEYPFRLHQVYFDAPSCVKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFMRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPASGGGGYGPQGDYGQQGYGQQGAPTSFSNQM
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
  • 基因功能参考文献：
    1. The environmental enrichment protected against the effects of maternal separation as indicated by the lower anxiety levels and the reversal of spatial memory deficits compared to animals housed in standard conditions. These changes were associated with increased synaptophysin expression in the hippocampus. PMID: 29545098
    2. Dexamethasone treatment significantly affects both GAP-43 and synaptophysin protein expression in the hippocampus of aged rats. PMID: 28801169
    3. Synaptophysin cerebellar cortex expression was significantly reduced in newborn animals from diabetic mothers. PMID: 27389246
    4. showed a significant down-regulation in mRNA expression of synaptophysin in the offspring born to diabetic animals PMID: 26794272
    5. Synaptophysin spinal cord levels were higher in balance and coordination trained animals compared with non-trained following sciatic nerve crush. PMID: 26316168
    6. the Nociceptin/orphanin FQ receptor system influences the expression of synaptophysin PMID: 25697061
    7. Results identified interesting differences between thienorphine and morphine in their effects on synaptic structure and synaptophysin expression in the rat NAc. PMID: 24861887
    8. Synaptophysin content was high in all the layers of the cortex, but the most intense reaction was detected in the molecular layer, similarly with the intensity of GFAP reaction PMID: 25282817
    9. data suggest that diabetes increases mRNA translation of synaptophysin in the retina, resulting in an accumulation of mannose rich glycosylated synaptophysin, a transient post-translational state of the protein PMID: 22970294
    10. Phosphorylation and nitration of tyrosine residues affect functional properties of Synaptophysin and Dynamin I. PMID: 23103755
    11. The expression of synaptophysin (SYP) and regenerationassociated protein (GAP43) in the injured brain of neural stem cells-transplanted rats was significantly increased. PMID: 21687946
    12. The developmental changes of GluR2 and SYP expression in the rat inferior colliculus may be involved in the development and plasticity of the auditory center. PMID: 20422983
    13. GAP-43 and P38 may be the pathological basis of insular epilepsy and the key molecular mechanism of synaptic plasticity. PMID: 20646586
    14. Our findings implicate decreases in the number of surviving cells and alterations in the levels of caveolin-1 and synaptophysin in the impairments in neural development induced by developmental iodine deficiency and hypothyroidism. PMID: 20025630
    15. stress during pregnancy reduced the expression of synaptophysin; this decrease provides evidence that synaptic integral membrane proteins are involved in altered synaptic plasticity in the adult CNS following stress exposure PMID: 20035832
    16. The expression level of synaptophysin showed dynamic changes following diffuse brain injury as well as during the repair period. PMID: 17330749
    17. Data suggest that synaptophysin I has multiple roles in neurotransmitter release, regulating VAMP2 availability for the soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex and participating in the late steps of exocytosis PMID: 12181340
    18. Synaptophysin mRNA increased in the barrel cortex contralateral to whisker stimulation, suggesting that synaptophysin is involved in the modulation of synaptic plasticity. PMID: 12363201
    19. We found a kindling-induced increase in synaptophysin in various hippocampal regions and in pyriform cortex, suggesting that activation-induced sprouting extends well beyond the hippocampal mossy fiber system. cortex PMID: 12453493
    20. Synaptophysin and gamma-adaptin occurred in the perinuclear region of hippocampal neurons, suggesting that synaptophysin serves as a docking site for AP-1 during clathrin-dependent vesicle budding and/or kinesin-based transport reactions. PMID: 12498786
    21. synaptophysin targeting to a ubiquitous synaptic vesicle-sized compartment is facilitated by cellugyrin and synaptogyrin PMID: 12928441
    22. Synaptophysin expression was assessed in dentate gyrus prepared from aged (22 months) and young (4 months) rats; marked reduction in synaptophysin expression in synaptosomes of aged compared with young rats was noted PMID: 12965244
    23. Restraint stress decreased SYP in rat hippocampus by 50% and increased microtubule-associated protein 1(MAP1) by 60%. SYP returned to pre-stress levels in three weeks and MAP1 in two weeks. PMID: 15584914
    24. Cognitive impairment and the expression patterns of MAP-2, GAP-43, and synaptophysin were examined in rats with permanent occlusion of bilateral common carotid arteries. PMID: 15964096
    25. The dose-response effects of Aroclor 1254 on the expression of alpha-synuclein, synaptophysin and parkin in rat brains is reported. PMID: 16174552
    26. Following clozapine treatment, synaptophysin expression increases in the very cortical regions in which GLT-1 expression is down-regulated. PMID: 16987241
    27. The mRNA expression level of synaptophysin induced by neuronal activity is related to the regulation of synapse formation or remodeling or both. PMID: 16990974
    28. Synaptophysin expression, which appeared diffusely across the cortex, increased on day 1, 3, and 5 of complex motor skill learning. PMID: 17141532
    29. AMPH administered in the AMPH-paired context increased the density of both Fos and synaptophysin immunoreactivity in the dentate gyrus, cornu ammonis (CA)1, CA3, basolateral amygdala and dorsolateral striatum. PMID: 17970739
    30. reduced synaptophysin protein levels in schizophrenia postmortem brains do not result from perinatal oxygen deprivation PMID: 18626794
    31. Synaptophysin gene is embedded in open chromatin in R28 retinal precursor cells. PMID: 18692536
    32. We found abnormal expression of the synaptic proteins synaptophysin, microtubule-associated protein 2 (MAP2) and cyclin-dependent kinase 5 (CDK5) and of the neurotrophin-3. PMID: 18703118
    33. Results show that nerve growth factor regulates the intracellular distribution of the synaptic vesicle protein synaptophysin in newborn rat trigeminal ganglion neurons in vitro. PMID: 19019428

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    Synaptophysin/synaptobrevin family
  • 组织特异性：
    Expressed in the brain with expression in the cerebrum and the cerebellum.
  • 数据库链接：

    KEGG: rno:24804

    STRING: 10116.ENSRNOP00000013724

    UniGene: Rn.11067