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  4. Recombinant Rat Potassium voltage-gated channel subfamily C member 1 (Kcnc1)

Recombinant Rat Potassium voltage-gated channel subfamily C member 1 (Kcnc1)

  • 中文名称：
    大鼠Kcnc1重组蛋白
  • 货号：
    CSB-CF012018RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Kcnc1
  • Uniprot No.：
  • 别名：
    Kcnc1; Potassium voltage-gated channel subfamily C member 1; NGK2; RAW2; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-585
  • 氨基酸序列
    MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRH PGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALD SFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALF EDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAE TEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPH HSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTR ERYGPCFLLSTGEYACPPGGGMRKDLCKESPVIAKYMPTEAVRVT
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
  • 基因功能参考文献：
    1. Trafficking-dependent roles of the Kv3.1b potassium channel are dependent on N229 site-specific glycosylation and N-glycan structure, and operate through a mechanism whereby specific N-glycan structures regulate cell surface expression. PMID: 28322444
    2. This study demonstrated that Kv3.1b potassium channel expression in motor cortex pyramidal cells. PMID: 28213922
    3. Our findings provide direct evidence that N-glycans of Kv3.1 splice variants contribute to the placement of these glycoproteins in the plasma membrane of neuronal-derived cells while those of Kv1.1 were absent. PMID: 26348848
    4. Results indicate that Src kinase may play an important role in regulating membrane trafficking of Kv3.1b channels. PMID: 24291260
    5. high-affinity multimeric binding between the Kv3.1 T1 domain and KIF5B requires three basic residues in the KIF5B tail. Kv3.1 T1 competes with the motor domain and microtubules, but not with kinesin light chain 1 (KLC1), for binding to the KIF5B tail. PMID: 23487040
    6. The unique N-terminus of DPP6K modulates the effects of KChIP proteins, slowing recovery and producing a negative shift in the steady-state inactivation curve. PMID: 22675523
    7. alternative splicing controls neuronal firing rates by regulating the polarized targeting of Kv3.1 channels. PMID: 22105078
    8. These results have demonstrated that N-glycans of the Kv3.1 glycoprotein enhance outward ionic current kinetics, and neuronal migration. PMID: 21541302
    9. study to elucidate the relative distribution of Kv3.1b and Kv3.3 in specific compartments of the parallel fibers in the cerebellar cortex PMID: 20857303
    10. A previously unknown interaction between the KV4 channel and Kv channel interacting protein (KChIP)3 in Muller cells could exert a physiological role in the onset of diabetic retinopathy. PMID: 21147063
    11. Net amounts of Kv3.1b protein can change on a time scale of minutes in response to stimulus-driven synaptic activity, permitting auditory neurons to actively adapt their complement of ion channels to changes in the acoustic environment. PMID: 20219640
    12. Kv3-like currents may be important for maintaining spike width and calcium influx within acceptable limits during repetitive firing. PMID: 15240761
    13. Synaptic inputs evoked by stimulation of a region lacking Kv3.1b-IR neurons were not affected, correlating the presence of Kv3.1b in the tractus solitarius with the pharmacological effects. [Kv3.1b] PMID: 15528247
    14. Both fast-firing and burst-firing parvalbumin+ interneurons in the basolateral amygdala express the Kv3.1b subunit. PMID: 16413129
    15. the Kv3.1b channel is regulated by both conventional and novel PKC isozymes, and novel PKC-delta contributes specifically to the maintenance of basal phosphorylation in auditory neurons PMID: 16595659
    16. The axon-dendrite targeting of Kv3.1 Shaw channel is controlled by a conditional interaction of a C-terminal axonal targeting motif with the N-terminal T1 domain and adaptor protein ankyrin G. PMID: 18094255
    17. Suggest that fluoxetine acts on Kv3.1 currents as an open-channel blocker. PMID: 18187934
    18. The results suggest that an altered expression of Kv3 channels affects the functional properties of FS neurons, and may contribute to the deficits in inhibition observed in the sensory-deprived cortex. PMID: 18708127
    19. Report effect of psoralen on the cloned Kv3.1 currents. PMID: 19387585

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane.
  • 蛋白家族：
    Potassium channel family, C (Shaw) (TC 1.A.1.2) subfamily, Kv3.1/KCNC1 sub-subfamily
  • 组织特异性：
    Expressed in brain. Expressed in globus pallidal neurons of the basal ganglia (at protein level). Detected on Purkinje cells in the cerebellum molecular layer (at protein level).
  • 数据库链接：

    KEGG: rno:25327

    STRING: 10116.ENSRNOP00000015260

    UniGene: Rn.33095