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  4. Recombinant Rat P2Y purinoceptor 6 (P2ry6)

Recombinant Rat P2Y purinoceptor 6 (P2ry6)

  • 货号：
    CSB-CF737185RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    P2ry6; P2Y purinoceptor 6; P2Y6
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-328
  • 氨基酸序列
    MERDNGTIQAPGLPPTTCVYREDFKRLLLPPVYSVVLVVGLPLNVCVIAQICASRRTLTR SAVYTLNLALADLLYACSLPLLIYNYARGDHWPFGDLACRLVRFLFYANLHGSILFLTCI SFQRYLGICHPLAPWHKRGGRRAAWVVCGVVWLVVTAQCLPTAVFAATGIQRNRTVCYDL SPPILSTRYLPYGMALTVIGFLLPFTALLACYCRMARRLCRQDGPAGPVAQERRSKAARM AVVVAAVFVISFLPFHITKTAYLAVRSTPGVSCPVLETFAAAYKGTRPFASANSVLDPIL FYFTQQKFRRQPHDLLQKLTAKWQRQRV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C.
  • 基因功能参考文献：
    1. This study suggested that spinal P2Y6 is present in spinal microglia while P2Y11 receptors are present in both spinal microglia and astrocytes, and both receptors are up-regulated in rats subjected to spinal nerve injury. PMID: 24886406
    2. Wound-induced UDP evokes intestinal epithelial restitution by activation of P2Y6 receptors, which mediates de novo synthesis of TGF-beta. PMID: 23941325
    3. Activation of P2Y6 receptors causes bladder overactivity in the anesthetized rat indirectly by releasing ATP. PMID: 24269631
    4. We speculate that P2Y(6) may be involved in retinal information processing in different ways PMID: 22728100
    5. Here we show that Plasmodium berghei ANKA infection of young rats leads to the modulation of expression of the G-protein-coupled receptor P2Y6. Susceptibility to malaria infection seems to be mediated by the alteration of genes expressing P2Y6R. PMID: 21323829
    6. prominent role for the UDP receptor, P2Y(6), in UTP-induced rat ASMC migration PMID: 11934835
    7. Activated hepatic stellate cells expressed the P2Y subtype P2Y(6). PMID: 14764443
    8. P2Y6 receptor-mediated ERK1/2 activation and phosphorylation are increased in uridine diphosphate-stimulated rat intestinal epithelial cells. PMID: 18250478

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Abundantly expressed in various tissues including lung, stomach, intestine, spleen, mesentery, heart, and, most prominently, aorta.
  • 数据库链接：

    KEGG: rno:117264

    STRING: 10116.ENSRNOP00000049439

    UniGene: Rn.10671