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  4. Recombinant Rat Nociceptin receptor (Oprl1)

Recombinant Rat Nociceptin receptor (Oprl1)

  • 货号：
    CSB-CF016360RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Oprl1; Oor; Oprl; Nociceptin receptor; Kappa-type 3 opioid receptor; KOR-3; Orphanin FQ receptor; ROR-C; XOR1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-367
  • 氨基酸序列
    MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCI GGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALC KTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGV PVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLR GVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRF CTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTS ETVPRPA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
  • 基因功能参考文献：
    1. The present in vitro and in vivo findings show that nociceptin/orphanin FQ receptor plays a crucial conserved role regulating the levels of the glutamate/aspartate transporter GLAST/EAAT1 in both human and rodent brain astrocytes. PMID: 28906039
    2. Genetic deletion of NOP receptors confers resilience to drug abuse and support a role for NOP receptor antagonism as a potential treatment option for drug addiction. PMID: 27562376
    3. Nociceptin/orphanin FQ mRNA is increased in the striatum from stressed, social defeat animal models. PMID: 28280884
    4. Findings suggest that the Galphai1/Gbeta2(beta4)/Ggamma7 heterotrimeric G protein complex determines the nociceptin/orphanin FQ peptide receptor-mediated modulation of voltage-gated Ca(2+) channels channels in stellate ganglion neurons. PMID: 27238748
    5. The opioid-like hepta-decapeptide nociceptin/orphanin FQ and its receptor nociceptin are widely distributed in the central nervous system where they are involved in a variety of biological functions including feeding, reward and emotional processes. PMID: 26387568
    6. This study demonstrated the expression of the NOP receptor in human peripheral nerve and visceral tissues, with a marked increase of NOP-positive nerve fibres in urinary bladder syndromes. PMID: 27127846
    7. Study shows an influence of the prelimbic nociceptin/orphanin FQ neurotransmission, but not the infralimbic nociceptin receptors, in the control of cardiovascular responses observed during acute stress, by increasing cardiac parasympathetic activity. PMID: 26935148
    8. Nociceptin-immunoreactive cells were observed in the central and peripheral regions of the islets of both normal and diabetic rat pancreas. PMID: 25875798
    9. This study demonistrated that Oprl1 and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain. PMID: 24978951
    10. Antagonism of endogenous N/OFQ produces anti-arrhythmic effects on ventricular arrhythmias in acute myocardial infarction, possibly via modulating PKC activity and action potential of myocytes. PMID: 23869704
    11. data are consistent with the interpretations that membrane estrogen receptor activation attenuates ORL1-mediated antinociception through a non-genomic, ERK 2-dependent mechanism in females PMID: 24452062
    12. These results confirm the existence of reciprocal interactions between serotonin and nociceptin/NOP transmissions in the dorsal raphe nucleus. PMID: 23669068
    13. Opioid/nociceptin receptor levels are increased in the cerebral cortex following kainic acid-induced seizures. PMID: 23337899
    14. the findings elaborate the effects of the N/OFQ-NOP system on cocaine-mediated extracellular dopamine; these studies confirm the widespread involvement of NOP receptors in drug addiction PMID: 23219985
    15. stress can affect N/OFQ expression and that glucocorticoids may constitute hormonal mediators of this complex interplay. PMID: 22074385
    16. ORL1 receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels PMID: 22371475
    17. Genetic knock-out of nociceptin receptor renders rats more susceptible to the rewarding effect of morphine. PMID: 21095077
    18. results indicate that the peripheral nociceptin/orphanin FQ (N/OFQ)-N/OFQ peptide (NOP) system is involved in stress-induced reduction of mucosal mast cell density PMID: 21925513
    19. NOP receptor signalling plays an important role in controlling anxiety- and mood-related behaviours, exercise-driven locomotor activity and nociception. PMID: 21184763
    20. present in the uterus PMID: 20237332
    21. These receptors exhibit differential blocker pharmacology and allosteric regulation by sodium. PMID: 20159949
    22. the existence of heterodimers between ORL1 and classical opioid receptors, with profound implications for effectors such as N-type calcium channels. PMID: 19887453
    23. Activation of spinal ORL-1 receptors prevents acute cutaneous neurogenic inflammation: role of nociceptin-induced suppression of primary afferent depolarization. PMID: 11973003
    24. ORL-1 receptors in layer V of anterior cingulate cortex are located on somatodendritic elements and deafferentation increases ORL-1 receptor binding. PMID: 12842128
    25. Long-term effects on brain opioid receptor like-1 receptors after short periods of maternal separation in rats. PMID: 12842289
    26. Expression of opioid receptor-like OP-4/ORL1 is detected in the intima of ex vivo rat aortic rings, where the signal is limited to the endothelial layer, and in endothelial cells from rat brain microvessels. PMID: 14660000
    27. These results provide the evidence that ORL1-mu opioid receptor heterodimerization and the resulting impairment of mu receptor-activated signaling pathways may contribute to ORL1-mediated antiopioid effects in the brain. PMID: 15748148
    28. ORL(1) was involved in nociceptive transmission of neuropathic pain PMID: 15862535
    29. ORL1 receptors are located on serotoninergic neurons in the dorsal raphe nucleus PMID: 15948180
    30. These results suggest that two C-terminal serine residues, Ser(334) and Ser(335), are required for homologous desensitization and agonist-induced phosphorylation of opioid receptor-like 1. PMID: 16019191
    31. These results suggest that opioid receptor like 1 receptors have an inhibitory effect at night, and a facilitative effect in the day, on phase changes. PMID: 16310969
    32. NOP receptor agonists evoked a hyperphagic effect while NOP receptor antagonists blocked the hyperphagic effect. PMID: 16483692
    33. Changes in expression of nociceptin and its receptor in spinal dorsal horn during electroacupuncture treatment for inflammatory pain were studied. PMID: 17493706
    34. Altered anxiety behavior was studied in nociceptin receptor gene knockout mice. PMID: 17499882
    35. Results suggest that NOP receptor activation is required for cannabinoids to produce hypothermia. PMID: 17512052
    36. In conclusion, we present a novel mutant rat lacking NOPr without compensatory changes in mu, delta and kappa opioid receptors. We anticipate that this mutant rat will have heuristic value to further understand the function of NOPr. PMID: 19527777
    37. These data suggest that the endogenous nociceptin system is responsive to changes in energy balance and that nociceptin receptors specifically within the dorsal raphe may be physiologically relevant to nociceptin's effects on appetite. PMID: 19765615

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Highly expressed in several brain areas, the intestine, liver and spleen. Detected in sympathetic stellate ganglion neurons.
  • 数据库链接：

    KEGG: rno:29256

    STRING: 10116.ENSRNOP00000047053

    UniGene: Rn.9762