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  4. Recombinant Rat Neurotensin receptor type 1 (Ntsr1)

Recombinant Rat Neurotensin receptor type 1 (Ntsr1)

  • 货号：
    CSB-CF016137RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Ntsr1; Ntsr; Neurotensin receptor type 1; NT-R-1; NTR1; High-affinity levocabastine-insensitive neurotensin receptor; NTRH
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-424
  • 氨基酸序列
    MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLDVNTD IYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLA MPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTL MSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGTHPGGLVCTPIVDTATVKVVIQV NTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGRV QALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYV SSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPTFSRKPNSMSSNHAFSTSATR ETLY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.
  • 基因功能参考文献：
    1. A thermostable variant termed enNTS1 exhibited the best combination of signaling capability and stability upon solubilization with detergents. Several well dispersed (13)CH3-methionine resonances were seen by solution NMR spectroscopy, many of which exhibited chemical shift changes upon the addition of the high affinity agonist peptide, NT8-13. PMID: 29596791
    2. Herein potential interaction between NTS1 receptor, dopaminergic D2 receptor and Na(+), K(+)-ATPase was studied.Results indicated that typical and atypical antipsychotic drugs differentially modulate the interaction between neurotensin and Na(+), K(+)-ATPase. PMID: 27586561
    3. NTS1 agonists as potentially novel drugs for the treatment of schizophrenia. PMID: 26783230
    4. Molecular dynamics simulations of NTS1 in bilayers are in agreement with the ESR data, and point to sites in the receptor where PS could interact with higher affinity PMID: 26926422
    5. Molecular dynamics simulation study on the neurotensin peptide receptor NTSR1 with neurotensin bound, with the aim of understanding the structural basis of thermostabilization and activation PMID: 25807267
    6. This study demonistrated that Ntsr1 and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain. PMID: 24978951
    7. Maternal separation-induced alternations of DNA methylation in the promoter region of NTSR1 in the amygdala may be associated with vulnerability to the development of anxiety disorders and depression in adulthood PMID: 24831231
    8. the crystal structure at 2.8 A resolution of Rattus norvegicus NTSR1 in an active-like state, bound to NTS(8-13), the carboxy-terminal portion of NTS responsible for agonist-induced activation of the receptor PMID: 23051748
    9. The high-affinity NT receptor may not be involved in ligand binding inhibition to muscarinic receptor by NT. PMID: 20403392
    10. NTR1-like immunoreactive GABAergic neurons are widely distributed in the deep layers of the prefrontal cortex. NTR1 may play a role in PFC interneuron regulation by neurotensin. PMID: 15716398
    11. Data showed a positive correlation between blood ethanol concentration and higher neurotensin receptor 1 density in putamen and ventral midbrain in High and Low Alcohol Sensitive rat lines. PMID: 16953387
    12. Neurotensin 1 receptors play a key role in the regulation of pain signaling in the spinal cord. PMID: 18182046
    13. The potentiating effects of neurotensin on DA and 5-HT release in the PFC are regulated by NTR1 receptors, probably located on dopaminergic and serotonergic nerve terminals or axons. PMID: 18835308

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Membrane raft.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Neurotensin receptor subfamily, NTSR1 sub-subfamily
  • 组织特异性：
    Detected in brain and small intestine.
  • 数据库链接：

    KEGG: rno:366274

    STRING: 10116.ENSRNOP00000035997

    UniGene: Rn.200149