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  4. Recombinant Rat NADPH oxidase 3 (Nox3)

Recombinant Rat NADPH oxidase 3 (Nox3)

  • 货号：
    CSB-CF015960RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Nox3
  • Uniprot No.：
  • 别名：
    Nox3; NADPH oxidase 3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-568
  • 氨基酸序列
    MPTCWILNESVSFVVALLWLAINIYLFIDTFCWYAEEESFFYTRVILGSALAWARASAVC LNFNCMLILLPVSRNFVSLVRGTSVCCRGPWRRQLDKNLKFHKLVAYGIAVNSVIHIVAH LFNLERYHLGQAKDAEGLLAALSKLGNAPNESYLNPVRTLYTGTTTQLLMTVSGITGLVI SLALILIMTSSTEFIRQSSYELFWYTHHIFIFLFISLAIHGGGRIIRGQTPESLRLHNVT FCRDHFDEWQEAASCPVPQFSGKEPSAWKWTLGPVVLYACEIIIRFWRSHQEVVITKVVS HPSAVLELHMKKRDFKMAPGQYIFIQCPSISPLEWHPFTLTSAPQEDFFSVHIRASGDWT EALLKAFGAEGQAPSELCSMPRLAVDGPFGGSLADVFHYPVSVCIATGIGVTPFASLLKS VWYKCCESQSLPGLSKVYFYWICRDAAAFEWFADLLLSLETQMSEQGKAHLLSYHIYLTG WDEYQAIHIALHWDESLDVITGLKQKTFYGRPNWNEEFKQIAYNHPSSSIGVFFCGPKAM SKTLQKMCRLYSSSDPRGVHFYYNKENF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.
  • 基因功能参考文献：
    1. These results suggested that the high expression levels of NOX3 increased oxidative stress in stroke-prone hypertensive rat cerebrum. PMID: 26830484
    2. NOX3 regulates stress-related genes in the cochlea, such as TRPV1 and KIM-1, and initiates apoptosis in the cochlea. PMID: 20214492
    3. NOX3 is a relevant source of ROS generation in the cochlear and vestibular systems and that NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to ototoxic drugs. PMID: 15326186
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 组织特异性：
    Expressed in the inner ear by the spiral glanglia and the organ of Corti.
  • 数据库链接：

    KEGG: rno:292279

    STRING: 10116.ENSRNOP00000022148

    UniGene: Rn.161761