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  4. Recombinant Rat Melanocortin receptor 3 (Mc3r)

Recombinant Rat Melanocortin receptor 3 (Mc3r)

  • 货号：
    CSB-CF013560RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Mc3r; Melanocortin receptor 3; MC3-R
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-323
  • 氨基酸序列
    MNSSCCPSSSYPTLPNLSQHPAAPSASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVI LAVVRNGNLHSPMYFFLLSLLQADMLVSLSNSLETIMIVVINSDSLTLEDQFIQHMDNIF DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALSLIVAIWVCCGICGVMFI VYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAALPPADGVAPQQHSCMKG AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA FRSLELRNTFKEILCGCNGMNVG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.
  • 基因功能参考文献：
    1. Study demonstrates an arcuate nucleus of the hypothalamus pro-opiomelanocortinergic projection onto ventral tegmental area dopaminergic neurons that modulates motivation for palatable food via activation of melanocortin 3 receptor signaling. PMID: 26852738
    2. Compared with low-activity rats, high-activity rats show enhanced mRNA expression of MCRs in the brain, specifically of MC3R in the paraventricular nucleus. PMID: 22643233
    3. These results show that immunization against the melanocortin-3 receptor resulted in the production of Abs with positive or negative allosteric properties. PMID: 21091037
    4. Identification of domains directing specificity of coupling to G-proteins PMID: 12045190
    5. role for PKC isozymes in gamma-2-MSH/MC3-R receptor signaling and in neuronal cell differentiation. PMID: 12906838
    6. Melanocortin MC3 receptor expression is detected in adult retina and superior colliculus. Following optic nerve transection expresssion is increased in retina and decreased in superior colliculus. PMID: 14660008
    7. MC3-R is not involved in leptin-stimulated or spontaneous growth hormone secretion PMID: 14688446
    8. These results suggest that the MC3-R is not involved in mediating the potentiation effect, adding further evidence to the argument that another melanocortin receptor exists. PMID: 15666803
    9. Efforts revealed a sequence consistent with that predicted by the rat genome, but different from the published receptor by three amino acids, all of which were located in the predicted second transmembrane domain. PMID: 15985309
    10. These data show that MC3-R is expressed in rat IMCD cells in a manner modulated by dietary sodium intake. PMID: 16195498
    11. Using a transgenic and pharmacological approach, we provide strong proof of concept for the development of selective MC3-R agonists as novel anti-inflammatory therapeutics. PMID: 17077300
    12. analysis of activation and endocytic internalization of melanocortin 3 receptor in neuronal cells PMID: 17405938
    13. Expression levels of melanocortin 3 receptor (MC3R) and melanocortin 5 receptor (MC5R) were not significantly affected by high dietary salt intake in either WKY or SP-SHR tissues. PMID: 17531155
    14. weight gain does not raise arterial pressure in the absence of a functional MC3/4 receptors in hypertension PMID: 18285617

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Brain.
  • 数据库链接：

    KEGG: rno:29310

    STRING: 10116.ENSRNOP00000005871

    UniGene: Rn.215838