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  4. Recombinant Rat Integrin beta-1 (Itgb1)

Recombinant Rat Integrin beta-1 (Itgb1)

  • 货号：
    CSB-CF011880RA(A4)
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Itgb1; Integrin beta-1; Beta oligodendroglia; Beta OL; Fibronectin receptor subunit beta; VLA-4 subunit beta; CD antigen CD29
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    21-798
  • 氨基酸序列
    QTDKNRCLKANAKSCGECIQAGPNCGWCTNTTFLQEGMPTSARCDDLEALKKKGCHPSDIENPRGSQTIKKNKNVTNRSKGMAEKLRPEDITQIQPQQLLLKLRSGEPQKFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTDRGEFFNELVGQQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNVYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSGNSSNVIQLIIDAYNSLSSEVILENSKLPDGVTINYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITANKCPNKESENQLKLNPLGFTEEVEVVLQFICKCNCQSHGIPASPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRENTNEIYSGKFCECDNFNCDRSNGLICGGNGVCRCRVCECYPNYTGSACDCSLDTVPCVATNGQICNGRGICECGACKCTDPKFQGPTCETCQTCLGVCAEHKECVQCRAFNKGEKKDTCAQECSHFNLTKVESREKLPQPVQVDPVTHCKEKDIDDCWFYFTYSVNSKGEAHVHVVETPDCPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    10xHis-SUMO-tag
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling.
  • 基因功能参考文献：
    1. alpha6 and beta1 integrins are induced in Schwann cells in the sciatic nerve after a crush injury, and the blocking of integrin activity by siRNA expression and by treatment with anti-integrin antibodies attenuates Schwann cell contact with cultured neurons and decreases neurite outgrowth. After nerve transection, the levels of alpha6 and beta1 integrins in the distal nerve stump are lower than corresponding nerve area... PMID: 29223350
    2. These results indicate that integrin alpha5beta1 expression on dopaminergic neurons plays an important role in the dopaminergic neurite outgrowth on striatal neurons. PMID: 28176845
    3. Transduction of rat bone marrow mesenchymal stem cells with ITGA5B1 lentivirus could prevent cell anoikis and increase nitric oxide production. PMID: 29324307
    4. TGFB1-induced chondrogenesis of bone marrow mesenchymal stem cells is promoted by low-intensity pulsed ultrasound through the integrin-mTOR signaling pathway. PMID: 29237506
    5. SEMA7A promotes seawater induced lung edema via plexin C1 and stimulates seawater induced lung inflammation via beta1 integrin. PMID: 28765893
    6. Bone marrow-mesenchymal stem cell treatment was able to accelerate the healing process of burns by increasing the thickness of the collagen and the percentage of integrin alpha2beta1, thus accelerating the cell migration involved during wound healing. PMID: 29023021
    7. The present results provide a new evidence on acupuncture-specific tissue response in terms of integrin induction, and further suggest that integrin activation may be involved in transmitting mechanosensory signals from the acupoint to afferent nerve fiber. PMID: 28760342
    8. The interaction of alpha2beta1 integrin to collagen I in the cellular microenvironment can regulate expression of LOX. PMID: 27169768
    9. Electric signals regulate the directional migration of oligodendrocyte progenitor cells via beta1 integrin. PMID: 27879672
    10. this study shows that experimental iabetes interferes with the osseointegration of implants by deferring expression of fibronectin and integrin alpha5beta1 PMID: 26093969
    11. Data indicate that estradiol-induced activation of integrin alpha5beta1 accelerates behavioral recovery of 6-OHDA-esioned hemi-Parkinsonian model. PMID: 26997644
    12. Beta1 integrin inhibits apoptosis induced by cyclic stretch in annulus fibrosus cells via ERK1/2 MAPK pathway. PMID: 26467923
    13. Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects on vascular smooth muscle cell proliferation/migration. PMID: 26520903
    14. Demonstrate complementary roles for KCa3.1 and TRPC4 channels with extracellular matrix and beta1-integrin in the regulation of alveolar repair processes. PMID: 26335442
    15. Results show that beta1 integrins were ubiquitously expressed throughout the bone and marrow, for both ovariectomized and control rats. PMID: 25974241
    16. albumin decreases precursor and mature forms of integrin-beta1 through reactive oxygen species-reticulum stress pathway in podocytes. PMID: 25713411
    17. a novel pathway wherein heparanse sequentially activates integrin beta1, HIF-2alpha, Flk-1, and p38MAPK/HSP27 with corresponding enhancement of angiogenesis PMID: 25754303
    18. Integrin-beta1 regulates chondrocyte proliferation and apoptosis through the upregulation of GIT1 expression PMID: 25715677
    19. These observations demonstrate an important role for beta1-integrin/ILK signaling in regulating astrogliosis from ESCs and suggest ILK as a potential target for limiting glial scar formation after nervous system injury. PMID: 25098415
    20. Data suggest that kindlin-2 (Kind2/Fermt2) interacts with integrin beta 1 (Itgb1) and actin alpha 2 (Actn2) and co-localizes to cardiac sarcomere at Z-disc; knockdown of Kind2 leads to dissociation of Itgb1 and Actn2. PMID: 26143257
    21. cells grown on the mature cardiac extracellular matrix are able to circumvent typical stiffness related cellular behaviors, likely through beta1 integrin binding to the complex composition. PMID: 25220424
    22. both alphanu and beta1 integrins interfered with Abeta-induced neurotoxicity in hippocampal neurons and that this mechanism partially contributes to the activation of the Integrin-FAK signaling pathway. PMID: 23755149
    23. We established that phosphorylation of FAK Y397 with association with beta1 and beta3 integrins occurs with pressure-induced eutrophic remodeling. PMID: 25300309
    24. These results indicate that a1b1 integrin signaling pathway determines the osteoinductive effect of nanotopography on mesenchymal stem cells PMID: 24122940
    25. Wnt3a enhances migration and adhesion of vascular smooth muscle cells by activating beta1-integrin. PMID: 24535659
    26. data suggested that the extracellular matrix stiffness stimulation signal was transduced into HCC cells via integrin beta1, and this signal activated the PI3K/Akt pathway and upregulated VEGF expression PMID: 24472554
    27. In cardiac myocytes, beta1-integrin expression regulates the expression of angiotensinogen. PMID: 23058350
    28. a novel MDA-7/IL-24-GAS3-beta1integrin-fibronectin signaling pathway that suppresses breast cancer growth, is reported. PMID: 23468528
    29. lymphoid cell kinase is the crucial effector of beta1-integrin signalling in Schwann cells PMID: 23715271
    30. Periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis in part by activating the ERK1/2 mitogenic signal through the integrin beta 1-Src-phospholipase C-gamma-1/Rac1-ERK1/2 pathway. PMID: 22890232
    31. CLCA splicing isoform is associated with adhesion through beta1-integrin and its scaffolding protein PMID: 23297403
    32. Tauroursodeoxycholic acid can directly activate intrahepatocytic beta integrins, which trigger signal transduction pathways toward choleresis. PMID: 22865233
    33. Mechanical force transduced by alpha(5)beta(1)-integrins triggered a myogenic response-like behavior in isolated renal vascular smooth muscle cells. PMID: 23325413
    34. the role of laminin-integrin signaling in retinal ganglion cell survival in vitro PMID: 23118988
    35. investigate the effects of the connecting segment-1 (CS-1) peptide therapy, which blocks FN-alpha4beta1 integrin leukocyte interactions, in a well-established model of 24-h cold liver ischemia-reperfusion injury PMID: 22812390
    36. Chondroitin sulfate proteoglycans digestion enhanced the motility of dendritic spines and induced the appearance of spine head protrusions in parallel with activation of beta1-integrins PMID: 23238717
    37. The laminin-binding integrin alpha7beta1 is oxidized by hydrogen peroxide at specific sites and thereby redox regulated in its binding activity. PMID: 22659335
    38. The finding that beta1 integrin neutralization was effective in the same time window for slice and behavioral experiments strongly suggests that integrin recovery triggers a temporally discrete, previously undetected second stage of consolidation. PMID: 22973009
    39. after experimental TBI, hippocampal neurons grew well on an OPN substrate with growth comparable to that seen on laminin, but showed a higher degree of primary neurites; growth on OPN was mediated through beta1 intregrins and CD44. T PMID: 22692550
    40. Blockade of integrin alpha4beta1 significantly inhibits the migration of activated CCR4-negative CD4 T cells to all of the inflammatory stimuli. PMID: 22664869
    41. beta1 integrin has an important physiological role in ADAM17 activity regulation. PMID: 22413019
    42. Reactive oxygen species are mandatory for CD29(integrin 1beta)-induced pro-survival signalling in cardiomyocytes. PMID: 22198504
    43. Data show that the expression of VE-cadherin was markedly decreased on hypoxia/reoxygenation cardiomyocytes, but was restored by angiopoietin-1 treatment through integrin-beta1-mediated extracellular signal-regulated kinase and caspase 9 phosphorylation. PMID: 21738954
    44. Integrins, in particular integrin beta3, are regulators of IGF-1, but not PDGF, signaling in osteoblasts. PMID: 21932337
    45. up-regulated via Rac1-dependent reactive oxygen species as part of the hypertrophic cardiomyocyte response PMID: 21620958
    46. alpha7beta1 integrin is a Schwann cell receptor for laminin-2. PMID: 17598176
    47. Data suggest that neural progenitor cell proliferation is modulated by the beta1 integrin/MAPK signaling pathway. PMID: 21696820
    48. elevated levels of perlecan domain V have a role in brain repair post stroke via VEGF and brain endothelial cell alpha5beta1 integrin PMID: 21747167
    49. OPN increases integrin beta1 expression in rat bone marrow-derived mesenchymal stem cells (rMSCs) and promotes rMSCs migration through the ligation to integrin beta1. PMID: 21136191
    50. Data shwo that that beta1 integrin activation in bone marrow mesenchymal stem cells was induced by soft substrate to a significantly greater degree than by stiff substrate. PMID: 21593411

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Recycling endosome. Melanosome. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, focal adhesion. Cell surface.
  • 蛋白家族：
    Integrin beta chain family
  • 数据库链接：

    KEGG: rno:24511

    STRING: 10116.ENSRNOP00000014785

    UniGene: Rn.25733