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  4. Recombinant Rat Gap junction alpha-4 protein (Gja4)

Recombinant Rat Gap junction alpha-4 protein (Gja4)

  • 货号：
    CSB-CF009447RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Gja4
  • Uniprot No.：
  • 别名：
    Gja4; Cxn-37; Gap junction alpha-4 protein; Connexin-37; Cx37
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-333
  • 氨基酸序列
    GDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGC TNVCYDQAFPISHIRYWVLQFLFVSTPTLIYLGHVIYLSRREERLRQKEGELRALPSKDP HVERALAAIEHQMAKISVAEDGRLRIRGALMGTYVISVLCKSVLEAGFLYGQWRLYGWTM EPVFVCQRAPCPHVVDCYVSRPTEKTIFIIFMLVVGVISLVLNLLELVHLLCRCVSREIK ARRDHDTRPAQGSASDPYPEQVFFYLPMGEGPSSPPCPTYNGLSSTEQNWANLTTEERLT STRPPPFVNAAPQGGQKSSSRPNSSASKKQYV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 基因功能参考文献：
    1. FFR levels increased along with decreased doses of siRNA CX37 lentivirus, indicating that siRNA CX37 lentivirus may reduce the risk of coronary atherosclerosis and provide a potential approach to treat coronary heart disease. PMID: 29049831
    2. Substituting alanine at serine residues 275, 302 and 328 eliminated Cx37-induced cell death, supported proliferation and reduced the GJCh closed state probability. PMID: 28818996
    3. Cx37-N55I and -Q58L mutations formed hemichannels with behavior and permeation properties similar to Cx37-WT (especially Q58L), but none of the mutants suppressed rat insulinoma cell proliferation. PMID: 25217644
    4. 7,12-Dimethylbenz[a]anthracene increases Cx37 and Cx43 expression prior to follicle loss and during follicle loss both Cx37 and Cx43 expressions are reduced in cultured rat ovaries. PMID: 24269759
    5. Differences in channel behavior of connexin 37 (Cx37) cytoplasmic loop mutants suggest that the Cx37-CT and pore-forming domains are both essential to growth suppression by Cx37. PMID: 24133065
    6. In the IVCs of IVC-banded ACF rats, which were exposed to a hemodynamic condition of high pressure and low flow velocity, the GJSNs and the TGJAs of Cx37 increased markedly. PMID: 20805582
    7. Renal epithelia express Cx37 in their basolateral membranes. PMID: 19828678
    8. Upregulation of connexin 37 mRNA after sciatic nerve injury causes thermal hyperalgesia; gap junctions thus may be responsible for this hyperexcitability. PMID: 11978404
    9. Demonstration of Cx37 as the dominant connexin expressed in the media of the caudal artery highlights the potential heterogeneity of Cx involvement in vascular smooth muscle. PMID: 12231561
    10. Renin-angiotensin system blockade corrects decreased expression of Cx37 and Cx40 in arterial endothelial cells of hypertensive rats, partly independently of blood pressure. PMID: 15016632
    11. Gap junctions, comprising connexins 37 and 40, transduce purinergic signals mediating renal autoregulation. PMID: 17928514
    12. Report regulation of connexin 37 gene expression during skeletal muscle regeneration in the adult rat. PMID: 19129462

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族：
    Connexin family, Alpha-type (group II) subfamily
  • 组织特异性：
    Highly expressed in lung.
  • 数据库链接：

    KEGG: rno:25655

    STRING: 10116.ENSRNOP00000019246

    UniGene: Rn.23406