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  4. Recombinant Rat Furin (Furin)

Recombinant Rat Furin (Furin)

  • 货号：
    CSB-CF009068RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Furin
  • Uniprot No.：
  • 别名：
    Furin; Fur; Pcsk3; Furin; Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACE; Prohormone convertase 3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    108-793
  • 氨基酸序列
    DVYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGRGIVVSILDDGIEKNHPDLAGNY DPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRML DGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGS IFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQN EKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLN ANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIEILAEPKDIGKRLEV RKTVTACLGEPNHISRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADG FNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASEGLSAPPESSGC KTLTSSQACVVCEEGFSLHQKSCVQRCPPGFTPQVLDTHYSTENDVEIIRASVCTPCHAS CATCQGPAPTDCLSCPSHASLDPVEQTCSRQSQSSRESRPQQPPPALRPEVEVEPRLRAG LASHLPEVLAGLSCLIIALIFGIVFLFLHRCSGFSFRGVKVYTMDRGLISYKGLPPEAWQ EECPSDSEEDEGRGERTAFIKDQSAL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-45).
  • 基因功能参考文献：
    1. these data suggest that furin may play an important role in regulating apoptosis and proliferation of granulosa cells. PMID: 23418414
    2. upregulated during the preovulatory period, which results in activation of proteinases associated with the breakdown of the follicular wall during ovulation PMID: 20375258
    3. integrin bidirectional signalling is critically controlled by furin PMID: 20076849
    4. significant pools of furin and proMT1-MMP along the surface of cells lining glomerular basement membranes PMID: 12665557
    5. CDX2 regulates furin expression in intestinal epithelial cells PMID: 16239403
    6. Disturbances of the MT1-MMP/furin interaction must account for a lack in extracellular matrix remodeling, increased deposition of glomerular basement membrane material, and loss of glomerular filtration integrity in diabetic glomerulopathy. PMID: 16541018

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  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Secreted. Endosome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Peptidase S8 family, Furin subfamily
  • 组织特异性：
    Cardiocytes (at protein level).
  • 数据库链接：

    KEGG: rno:54281

    STRING: 10116.ENSRNOP00000015521

    UniGene: Rn.3220