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  4. Recombinant Rat C-C chemokine receptor type 2 (Ccr2)

Recombinant Rat C-C chemokine receptor type 2 (Ccr2)

  • 货号：
    CSB-CF004841RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Ccr2; Cmkbr2; C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; CD antigen CD192
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-373
  • 氨基酸序列
    MEDSNMLPQFIHGILSTSHSLFPRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPP LYSLVFIFGFVGNMLVIIILISCKKLKSMTDIYLFNLAISDLLFLLTLPFWAHYAANEWV FGNIMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVV AVFASLPGIIFTKSEQEDDQHTCGPYFPTIWKNFQTIMRNILSLILPLLVMVICYSGILH TLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQEFLGMSNCVVDMHLDQAM QVTETLGMTHCCVNPIIYAFVGEKFRRYLSIFFRKHIAKNLCKQCPVFYRETADRVSSTF TPSTGEQEVSVGL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Key functional receptor for CCL2 but can also bind CCL7 and CCL12. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. Mediates the recruitment of macrophages and monocytes to the injury site following brain injury.
  • 基因功能参考文献：
    1. CCR2 activation in nociceptive dorsal root ganglia neurons plays a role in the pathogenesis of gastric hyperalgesia associated with diabetic gastropathy. PMID: 29359616
    2. Light exposure led to apoptosis of photoreceptors, which expressed CCL2, accelerating an inflammation-mediated cascade by activating and attracting microglia and monocytes and promoting their secretion of CCL2 in the injured position. PMID: 29142497
    3. Expressions of CCR2 mRNA began to increase on the 1st day and reached to the peak on the 7th day, but then started to decrease gradually until 28th day. PMID: 26062549
    4. Results suggest that CCL2/CCR2 in the dorsal root ganglion and spinal cord is involved in the maintenance of lumbar disc herniation-induced pain PMID: 24462503
    5. investigated the expression changes and cellular localization of spinal CCR2 in a rat model of bone cancer induced by Walker 256 cell inoculation. expression of CCR2 in the spinal cord was significantly increased on day 6, 12, and 18 in bone cancer rats PMID: 23511129
    6. Report functional roles for CCL2/CCR2 signaling at the level of the urinary bladder in reducing voiding frequency and somatic sensitivity following CYP-induced cystitis. PMID: 23594826
    7. Overexpression of CCR2 in retinal microglia promotes their chemotaxis in response to chemokines. PMID: 23288990
    8. CCR2 is involved in the process of mast cell degranulation in bladder tissues. PMID: 23049171
    9. The IL-1beta and CCL2-CCR2 signaling cascades play a role in neuron-glia-cytokine interactions and the descending facilitation of neuropathic pain. PMID: 22466130
    10. the important role of CCR2 in neuropathic pain PMID: 21143971
    11. The expressions of CCR2 mRNA and protein increase significantly in cerebral tissue of newborn rat with hypoxic-ischemic brain damage. PMID: 18095591
    12. The data show that CCR2 and CCL2 regulation in the hippocampus changes after pilocarpine-induced status epilepticus or seizures. These changes might be involved in detrimental neuroplasticity and neuroinflammatory changes that occur following seizures. PMID: 20034406
    13. expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and its receptor in the testis of rats undergoing autoimmune orchitis PMID: 14638441
    14. CCR1, CCR2, and CCR5 mRNA expression and tyrosine phosphorylation increased with peak inflammation in adjuvant induced arthritis PMID: 14674010
    15. Cultured neural progenitor cells from the subventricular zone of adult rat brain express chemokine receptor CCR2. PMID: 14732474
    16. Arterial wall and VSMC MCP-1/CCR2 increase with aging. MCP-1 enhances VSMC migration and invasion, and thus, MCP-1/CCR2 signaling may play a role in age-associated arterial remodeling. PMID: 15178559
    17. IFNG priming enhances migration to inflammatory chemokines; IFN-gamma-inducible gene expression is attenuated by high levels of Stat1; physiological regulation of the relative abundance of Stat1 and Stat3 impacts on gene expression PMID: 16148108
    18. MCP-1/CCR2 signaling is directly involved with a chronic compression injury and may contribute to associated neuronal hyperexcitability and neuropathic pain. PMID: 16174730
    19. Data show that the preferential chemokine receptor (CCR)2 ligand, MCP-1/CCL2, elicits calcium transients in primary cultured neurons from various rat brain regions expressing CCR2. PMID: 16196033
    20. CCR2 mediates recruitment of both infiltrating macrophages and resident microglia to specific sites of central nervous system inflammation. PMID: 17484785
    21. These data suggest CCL2 and CCR2 as potential candidates for integrating inflammation and central neuropathic pain after spinal cord injury PMID: 18338959
    22. CCR2 was also expressed in laser-induced CNV but did not increase after PDT. PMID: 18421085
    23. Ccr2 is upregulated by injury to sensory neurons in the lumbar dorsal root ganglia and MCP-1/Ccr2 signaling contributes to subsequent changes in neural activity. These changes may contribute to neuropathic pain. PMID: 16174730

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in lung, spleen, kidney, thymus and macrophages.
  • 数据库链接：

    KEGG: rno:60463

    UniGene: Rn.211983