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  4. Recombinant Rat Atrial natriuretic peptide receptor 3 (Npr3)

Recombinant Rat Atrial natriuretic peptide receptor 3 (Npr3)

  • 货号：
    CSB-CF016025RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Npr3
  • Uniprot No.：
  • 别名：
    Npr3; Npr-cAtrial natriuretic peptide receptor 3; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    41-535
  • 氨基酸序列
    EALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALLYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTAKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFKMRSNVKYPWGSLKLRIDETRIVEHTNSSPCKSCGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNHQEESNIGKHRELREDSIRSHFSVA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    10xHis-SUMO-tag
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
  • 基因功能参考文献：
    1. These results indicate that C-ANP4-23, via the activation of NPR-C, attenuates Ang II-induced enhanced nitroxidative stress, overexpression of Gialpha proteins, increased activation of the p38/JNK/ERK 1,2 signaling pathways. PMID: 29417337
    2. NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF-alpha, which are regulators of apoptosis. PMID: 27494651
    3. down-regulation of Npr3 gene improves the circulatory levels of ANP and antioxidant system and there by attenuates the beta-adrenoceptor over-activation mediated cardiac hypertrophic growth PMID: 27108789
    4. Results from this study point to a role for miR-100 in the regulation of NPR3 expression, and suggest a possible therapeutic target for modulation of NP bioactivity in heart disease. PMID: 25736855
    5. the increased expression of NPR-C (r=-0.943 and -0.837 for mRNA and protein respectively, p<0.05) and NEP (r=-0.687 and -0.823 for mRNA and protein respectively, p<0.05) were accompanied by a signi fi cant decline in CNP. PMID: 24189506
    6. These results indicate that NPR-C activation by C-ANP4-23 attenuates the enhanced levels of cell cycle proteins through the inhibition of enhanced expression of Gialpha proteins PMID: 24155894
    7. knockdown of NPR-A up-regulates the expression of NPR-C, Gialpha proteins, and NPR-C-linked adenylyl cyclase signalling and suggests a cross-talk between NPR-A and NPR-C. PMID: 22131352
    8. NPR-B mRNA expression was found in both cardiac cells as well as endothelial cells. PMID: 21723350
    9. data presented here suggest that rat NPRC is a substrate for PKA and Thr 505 located within the intracellular domain of NPRC is a likely candidate site for the phosphorylation PMID: 20564198
    10. results demonstrate that NPRs are clearly expressed in the cells located in the ganglion cell layer including the three major subtypes of retinal ganglion cells and the expression is mainly on the membrane of somata PMID: 20304036
    11. The data suggest that in our left ventricular hypertrophy model, the NPR-A and NPR-C receptors were increased in association to the increased BNP level. PMID: 19969282
    12. These data suggest that natriuretic peptides may play a role in maintaining the retinal functions via interaction with NPR-C. PMID: 19878700
    13. Modulation of ANP-C receptor signaling by endothelin-1 in A-10 smooth muscle cells PMID: 12054468
    14. data suggest that C-type natriuretic peptide attenuates neurotransmitter efflux by a mechanism involving suppression of neuronal protein kinase C activity via an interaction with the natriuretic peptide C receptor PMID: 12488334
    15. 17-amino acid sequence (R(469) to R(485)) in the middle region of the intracellular domain of NPR-C is both necessary and sufficient for activation of G proteins and effector enzymes. PMID: 12676657
    16. findings support that ANF exerts a stimulatory effect on pancreatic exocrine secretion mediated by NPR-C receptors coupled to the phosphoinositide pathway PMID: 12829435
    17. participation of NPR-C receptors in C-type natriuretic peptide response PMID: 14599710
    18. a cross-talk between ANP-C receptor-mediated adenylyl cyclase and PLC signaling pathways. PMID: 15044621
    19. Endothelium-derived CNP is involved in the regulation of the coronary circulation, and NPR-C activation underlies the vasorelaxant activity of this peptide. Moreover, this newly defined pathway represents a protective mechanism against I/R injury. PMID: 15337698
    20. The downregulation of ANP and NPRC in retinas of diabetic rats suggests a role for this peptide in experimental diabetic retinopathy. PMID: 15789000
    21. discussion of neuronal regulation and function of natriuretic peptide receptor C [review] PMID: 15911073
    22. Results show that natriuretic peptide receptor NPR-C mediates the activation of nitric oxide synthase by atrial natriuretic peptide in atria. PMID: 16712979
    23. NPRC is a potential direct regulator of pancreatic function. PMID: 17702953
    24. Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide. PMID: 17951249
    25. These results suggest that C-ANP(4-23) decreases the enhanced oxidative stress in spontaneously hypertensive rats by attenuating the enhanced expression of Gialpha proteins and also the enhanced levels of NADPH oxidase. PMID: 18162186
    26. our results suggest the existence of a local and complex peptidergic system in the rat testis, involving ANP and its receptors that could importantly modulate the androgen biosynthesis. PMID: 18778744
    27. Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy PMID: 19187227
    28. temporal relationship follows between a NO-induced decreased expression of NPR-C and G(i)alpha proteins PMID: 19252090

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    ANF receptor family
  • 数据库链接：

    KEGG: rno:25339

    STRING: 10116.ENSRNOP00000025966

    UniGene: Rn.11297