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  4. Recombinant Mouse Zinc transporter 1 (Slc30a1)

Recombinant Mouse Zinc transporter 1 (Slc30a1)

  • 货号：
    CSB-CF733704MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Slc30a1
  • Uniprot No.：
  • 别名：
    Slc30a1; Znt1; Zinc transporter 1; ZnT-1; Solute carrier family 30 member 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-503
  • 氨基酸序列
    MGCWGRNRGRLLCMLLLTFMFMVLEVVVSRVTASLAMLSDSFHMLSDVLALVVALVAERF ARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAVERFIEPHEMQQPLVVLSVG VAGLLVNVLGLCLFHHHSGEGQGAGHGHSHGHGHGHLAKGARKAGRAGVEAGAPPGRAPD QEETNTLVANTSNSNGLKADQAEPEKLRSDDPVDVQVNGNLIQESDNLEAEDNRAGQLNM RGVFLHVLGDALGSVIVVVNALVFYFNWKGCTEDDFCTNPCFPDPCKSSVEIINSTQAPM RDAGPCWVLYLDPTLCIIMVCILLYTTYPLLKESALILLQTVPKQIDIKHLVKELRDVDG VEEVHELHVWQLAGSRIIATAHIKCEDPASYMQVAKTIKDVFHNHGIHATTIQPEFASVG SKSSVLPCELACRTQCALKQCCGTRPQVHSGKDAEKAPTVSISCLELSENLEKKARRTKA EGSLPAVVIEIKNVPNKQPESSL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention.
  • 基因功能参考文献：
    1. This study has identified ZnT1 as a novel postsynaptic density protein. PMID: 24602382
    2. C-terminal domain of ZnT-1 was responsible for its protective effect against ischemia-reperfusion , while this part of the ZnT-1 protein did not have a protective effect against the toxicity of zinc PMID: 22193398
    3. Data suggest that expression of zinc homeostatic proteins such as ZnT1 and 3, and metallothioneins 1 and 2, is regulated by crosstalk between synaptic and intracellular pools of Zn(2+). PMID: 20432464
    4. Expression of zinc transporter ZnT1 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain. PMID: 15257151
    5. Znt1 provides an essential function during early embryonic development. PMID: 15452870
    6. Cadmium exposure down-regulated ZnT-1 gene expression in the conceptus of mice. PMID: 17669619
    7. The expression of Slc30a1, Slc39a8, and Slc39a10 in the erythrocytes of zinc deficient and replete mice is reported. PMID: 18936201

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:22782

    STRING: 10090.ENSMUSP00000042410

    UniGene: Mm.9024