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  4. Recombinant Mouse Vasoactive intestinal polypeptide receptor 2 (Vipr2)

Recombinant Mouse Vasoactive intestinal polypeptide receptor 2 (Vipr2)

  • 货号：
    CSB-CF025860MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Vipr2; Vasoactive intestinal polypeptide receptor 2; VIP-R-2; Pituitary adenylate cyclase-activating polypeptide type III receptor; PACAP type III receptor; PACAP-R-3; PACAP-R3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-437
  • 氨基酸序列
    ECRFHLEIQEEETKCAELLSSQTENQRACSGVWDNITCWRPADVGETVTVPCPKVFSNFY SRPGNISKNCTSDGWSETFPDFIDACGYNDPEDESKISFYILVKAIYTLGYSVSLMSLTT GSIIICLFRKLHCTRNYIHLNLFLSFMLRAISVLVKDSVLYSSSGLLRCHDQPASWVGCK LSLVFFQYCIMANFYWLLVEGLYLHTLLVAILPPSRCFLAYLLIGWGIPSVCIGAWTATR LSLEDTGCWDTNDHSIPWWVIRMPILISIVVNFALFISIVRILLQKLTSPDVGGNDQSQY KRLAKSTLLLIPLFGVHYMVFAAFPIGISSTYQILFELCVGSFQGLVVAVLYCFLNSEVQ CELKRRWRGLCLTQAGSRDYRLHSWSMSRNGSESALQIHRGSRTQSFLQSETSVI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.
  • 基因功能参考文献：
    1. Findings suggest that the vasoactive intestinal peptide receptor 2 plays an important role in the fear extinction processes and the regulation of the dendritic morphology in the prelimbic and infralimbic cortices. PMID: 29030297
    2. Results demonstrate critical protective roles for PACAP and the VPAC2 receptor against autoimmunity, promoting the expansion and maintenance of the Treg pool. PMID: 25305591
    3. The results suggest that caveolin-1 plays an important role in VPAC2 receptor internalization and desensitization. PMID: 23499767
    4. Cumulus cells express PACAP and its receptors PAC1-R and VPAC2-R. PMID: 23684890
    5. VPAC2R mRNA expression showed a nonsignificant tendency to increase on day 7 after ischemia induced by bilateral common carotid artery occlusion. PMID: 22669509
    6. The loss of adrenal clock gene rhythm in the VPAC2 receptor knockout mice after transfer into constant darkness was accompanied by disappearance of rhythmicity in Star mRNA expression and serum corticosterone concentration. PMID: 22622901
    7. Cyclophosphamide-induced cystitis significantly decreased VPAC2 receptor expression in the urothelium & detrusor of both WT and NGF-OE mice PMID: 22700375
    8. The circadian clock, not ambient light level, regulates Vipr2 protein localization, since VAPC2R plays a role in signaling at all times of day. PMID: 22684939
    9. while the main rhythm parameters of extra-SCN circadian oscillations are maintained in Vipr2(-/-) mice, the ability of these oscillators to resist phase shifts is compromised PMID: 21559484
    10. Cellular synchrony in electrical firing rates was lost in suprachiasmatic nucleus slices lacking the VPAC2 receptor for VIP. PMID: 21628548
    11. The absence of VPAC2 leads to aberrant antibody production in Aspergillus fumigatus sensitized and challenged mice PMID: 20923692
    12. VPAC2 signaling is necessary for a functional circadian clock driving locomotor activity, core body temperature, and heart rate rhythmicity. VPAC2-deficient mice lose the rhythms in all three parameters under constant light/darknessconditions. PMID: 21178124
    13. absence of VPAC(2) does not protect mice from developing the signs and symptoms of allergic asthma. PMID: 20226823
    14. We also show that VPAC(2) receptor activation shifts the fate of symmetrically dividing NSPCs toward a nestin-only phenotype, independent of the trophic effect. PMID: 19650041
    15. Mice lacking the VPAC2 receptor for VIP and PACAP lose normal circadian rhythms of rest/activity behavior. They also lose circadian expression of the clock genes mPer1, mPer2, mCry1 and arginine vasopressin in the SCN. PMID: 12086606
    16. RT PCR demonstrated mRNA for VPAC2 in the trigeminal ganglion. Immunocytochemistry showed VPAC2 in small-diameter TG neurons. Thus, PACAP and VIP are potential mediators of cross-excitation in the TG. PMID: 12225867
    17. VPAC2 receptor is found predominantly in smooth muscle (in blood vessels and in the smooth muscle layers of the gastrointestinal and reproductive systems), mucosal epithelium in the colon, lung, the vasculature of the kidney, adrenal medulla, and retina PMID: 14617572
    18. Absence of photic gating, together with the general lack of overt rhythms in circadian output, strongly suggests the circadian pacemaker is completely dysfunctional in the Vipr2(-/-) mouse PMID: 15071099
    19. Vasoactive intestinal peptide binding to VPAC(2) on CD4 T cells specifically induces an up-regulation of the Th2-type transcription factors c-Maf and JunB, which consequently enhances IL-4 and IL-5 production, leading to a Th2-type phenotype. PMID: 15187104
    20. analysis of a mutant form of VPAC2 shows its role in signaling and ligand binding PMID: 15302876
    21. These studies indicate that VPAC2R agonists may have utility for the treatment of skeletal muscle-wasting diseases. PMID: 15649881
    22. Data describe the involvement of conserved amino acid sequences in VPAC(2) signal transduction and regulation. PMID: 15821106
    23. Residual electrical oscillations persist in the suprachiasmatic nuclei of Vipr2(-/-) mice. PMID: 16319315
    24. The Vipr2 gene encoding the VPAC2 receptor for VIP is necessary both to maintain molecular timekeeping within individual SCN neurons and to synchronize molecular timekeeping between SCN neurons embedded within intact, organotypical circuits. PMID: 16546085
    25. The ratio of two forms of T cell VPAC2 determines the net effect of vasoactive intestinal peptide (VIP) on IL-4 generation by activated T helper type 2 (Th2) cells. PMID: 16709822
    26. splice variants may modify the immunoregulatory contributions of the VIP-VPAC2 axis PMID: 16888203
    27. Vipr2 gene may be differentially active in different mouse strains, depending on the presence of this LINE-1-like sequence in the promoter region. PMID: 17184482
    28. In Vipr2 knockout mice there is significantly lower expression of period1 expression and lower amplitude oscillations compared to wild type. PMID: 18554318
    29. Data show that VIP and the VPAC2R are critical for the normal functioning of the circadian system. PMID: 18616823
    30. PACAP/VIP can activate adenylate cyclase response and regulate IL-6 release through VPAC2 receptor. PMID: 19496170

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 组织特异性：
    Expressed at high levels in the MIN6 cells, at moderate levels in pancreatic islets, insulin-secreting cells, lung, brain, stomach, and colon, and at low levels in the heart.
  • 数据库链接：

    KEGG: mmu:22355

    STRING: 10090.ENSMUSP00000011315

    UniGene: Mm.395245