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  4. Recombinant Mouse Trimeric intracellular cation channel type B (Tmem38b)

Recombinant Mouse Trimeric intracellular cation channel type B (Tmem38b)

  • 中文名称：
    小鼠Tmem38b重组蛋白
  • 货号：
    CSB-CF872037MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Tmem38b
  • Uniprot No.：
  • 别名：
    Tmem38b; D4Ertd89e; Mg33b; Trimeric intracellular cation channel type B; TRIC-B; TRICB; Mitsugumin-33B; Transmembrane protein 38B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-292
  • 氨基酸序列
    MEYPWDDLTLAFSRTSMFPFFDIAHYLVSVMALKQRPGAVAAAWNNPLASWLSAMLHCFG GGILSCMLLAESPLKFLTNHTNILLASSIWYIVFFCPRDLVSQGYSYQPIQFLAAGMKEV TRTWKIVGGVSDANSYYRNAWIVMIVVGWARGAGGAVVTACEQLLKGDWKPEGDEWLKMS FPCKITLLGSIMFTFQHTRHLAISKHDLMFLYTIFLVTIKVTMMMTKDTAVTLTPFEDTL TRMLFGRRQQQQFSSSEKKTEVKPSSNGSASSASKRGAEPSGGAKRHAKKED
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
  • 基因功能参考文献：
    1. TRIC-B function is essential to support the production and release of large amounts of collagen by osteoblasts, which is necessary for bone mineralization PMID: 27188440
    2. This mini-review focuses on the essential role of TRIC-B channels in bone ossification. PMID: 27803445
    3. Study found that a simplified, linear, six-state gating model best encompasses the complexity of the subconductance gating behavior of TRIC-B channels PMID: 26200862
    4. Rapid transitions between TRIC-B sub-conductance states prevented development of reliable gating models. PMID: 23467973
    5. TRIC-A and TRIC-B seem to have differential functions in Ca(2+) signaling in excitable and nonexcitable cells. PMID: 24526676
    6. TRIC channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores PMID: 17611541
    7. TRIC-B-knockout neonates were cyanotic owing to respiratory failure and died shortly after birth. In mutant neonates, the deflated lungs exhibited severe histological defects, and alveolar type II epithelial cells displayed ultrastructural abnormalities. PMID: 19515693

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    TMEM38 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:52076

    STRING: 10090.ENSMUSP00000030127

    UniGene: Mm.27184