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  4. Recombinant Mouse Transmembrane 7 superfamily member 4 (Tm7sf4)

Recombinant Mouse Transmembrane 7 superfamily member 4 (Tm7sf4)

  • 货号：
    CSB-CF023625MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Dcstamp
  • Uniprot No.：
  • 别名：
    Dcstamp; Tm7sf4; Dendritic cell-specific transmembrane protein; DC-STAMP; mDC-STAMP; Dendrocyte-expressed seven transmembrane protein; Transmembrane 7 superfamily member 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-470
  • 氨基酸序列
    MRLWTLGTSIFLRLWGTYVFPRSPSWLDFIQHLGVCCFVAFLSVSLFSAAFYWILPPVAL LSSVWMITCVFLCCSKRARCFILLAVLSCGLREGRNALIAAGTGVVIFGHVENIFYNFRG LLDSMTCNLRAKSFSVHFPLLKRYTEAIQWIYGLATPLNLFDDLVSWNQTLVVSLFSPSH ALEAHMNDTRGEVLGVLHHMVVTTELLTSVGQKLLALAGLLLILVSTGLFLKRFLGPCGW KYENVYITKQFVRFDEKERHQQRPCVLPLNKKERKKYVIVPSLQLTPKEKKTLGLFFLPV LTYLYMWVLFAAVDYLLYRLISSMNKQFQSLPGLEVHLKLRGEKQGTQGVVHDSAFNISM FEPSCIPKPRLSVSETWVPLSIILLTLIILGLLSSMLMQLKILVSVSFYPKVERERIEYL HAKLLEKRSKQPLREADGKPSLYFKKIHFWFPVLKMIRKKQTIPANEDDL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.
  • 基因功能参考文献：
    1. These results suggested that hyperphosphatemia in the patients with CKD suppresses bone resorption by inhibiting osteoclastogenesis, and this impairs the regulation of bone metabolism. PMID: 28939042
    2. Immunoreceptor tyrosine-based inhibitory motif DC-STAMP is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca(2+) axis. PMID: 27723141
    3. These results suggest that Luman regulates the multinucleation of osteoclasts by promoting cell fusion of mononuclear osteoclasts through DC-STAMP induction and intracellular distribution during osteoclastogenesis. PMID: 26503158
    4. miR-7b inhibits osteoclastogenesis and cell-cell fusion by directly targeting DC-STAMP. PMID: 25123438
    5. our data indicate that Pin1 is a determinant of bone mass through the regulation of the osteoclast fusion protein DC-STAMP PMID: 24891219
    6. Mechanical vibration of osteoclast precursor cells reduces DC-STAMP expression in osteoclast precursor cells. PMID: 23994170
    7. DC-STAMP, Siglec-15, Tspan7 and Mst1r expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro. PMID: 23945674
    8. Results indicate that NFATc1 binding to the DC-STAMP promoter was inhibited by 60.9% with RvE1 treatment. PMID: 23629863
    9. Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. PMID: 23980096
    10. These results suggest that short-term mechanical stress strongly inhibits osteoclastogenesis through the downregulation of DC-STAMP. PMID: 23292096
    11. found that DC-STAMP, a key regulator of osteoclast cell fusion, is a direct target gene of Tal1 and show that Tal1 represses DC-STAMP expression by counteracting the activating function of the transcription factors PU.1 and MITF PMID: 21990371
    12. DC-STAMP is an ITIM-bearing molecule. Based on the 4 distinct patterns of DCSTAMP on human PBMC, it has potential to serve as a susceptible biomarker of psoriasis (Ps) as well as severity marker of Psoriatic Arthritis (PsA). PMID: 21987375
    13. regulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells PMID: 21978263
    14. CCN2 expressed during osteoclastogenesis promotes osteoclast formation via induction of and interaction with DC-STAMP PMID: 20721934
    15. DC-STAMP is expressed on osteoclast precursors as a dimer. RANKL induces osteoclastogenesis by stimulating DC-STAMP internalization in some osteoclast progenitors. PMID: 20039274
    16. DC-STAMP has an essential role in osteoclastogenesis. PMID: 15452179
    17. DC-STAMP expression is regulated differently in osteoclasts and macrophage giant cells. PMID: 17402846
    18. the expression of DC-STAMP affects myeloid development of hematopoietic progenitor cells, specifically suppressing granulocytic development PMID: 17713547
    19. dendritic cell antigen presentation activity is up-regulated in DC-STAMP-deficient mice; autoimmunity is present PMID: 18653699
    20. DC-STAMP over-expressing transgenic mice under the control of an actin promoter showed significantly accelerated cell-cell fusion of osteoclasts and bone resorption, with decreased osteoblastic activity and bone mass. PMID: 18952053

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endosome. Note=Localized to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes.
  • 组织特异性：
    Expressed in macrophages and bone marrow dendritic cells (BM-DC). Weakly expressed in the spleen and lymph node. Highly expressed in multi-nuclear osteoclasts compared to mono-nuclear macrophages. Expressed in foreign body giant cells (FBGCs). Isoform 1 a
  • 数据库链接：

    KEGG: mmu:75766

    STRING: 10090.ENSMUSP00000022913

    UniGene: Mm.159563