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  4. Recombinant Mouse Thromboxane A2 receptor (Tbxa2r)

Recombinant Mouse Thromboxane A2 receptor (Tbxa2r)

  • 货号：
    CSB-CF023260MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Tbxa2r; Thromboxane A2 receptor; TXA2-R; Prostanoid TP receptor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-341
  • 氨基酸序列
    MWPNGTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRS SFLALLCGLVLTDFLGLLVTGAIVASQHAALLDWRATDPSCRLCYFMGVAMVFFGLCPLL LGAAMASERFVGITRPFSRPTATSRRAWATVGLVWVAAGALGLLPLLGLGRYSVQYPGSW CFLTLGTQRGDVVFGLIFALLGSASVGLSLLLNTVSVATLCRVYHTREATQRPRDCEVEM MVQLVGIMVVATVCWMPLLVFIMQTLLQTPPVMSFSGQLLRATEHQLLIYLRVATWNQIL DPWVYILFRRSVLRRLHPRFSSQLQAVSLRRPPAQAMLSGP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.
  • 基因功能参考文献：
    1. The results suggest that EP3 along with TP contributes to vasoconstrictor responses evoked by PGI2, and hence imply a novel mechanism for endothelial cyclooxygenase metabolites (which consist mainly of PGI2) in regulating vascular functions. PMID: 28165064
    2. platelet GP6 and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation PMID: 27818280
    3. Genetic deletion of thromboxane receptor in adipose-derived stromal cells accelerated endothelial cell differentiation. PMID: 26957525
    4. PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2, possibly via increased pulmonary arterial TP receptor expression. PMID: 26890419
    5. Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor, which partially requires the activation of P2X1R through an endothelium-dependent mechanism. PMID: 25921923
    6. It is an active player in the pathogenesis of Alzheimer's disease. PMID: 25457549
    7. Adhesion of platelets through thromboxane A receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity. PMID: 25921763
    8. The results indicate that the beta1-subunit can form a tripartite complex with TP and MaxiKalpha, has the ability to associate with each protein independently. PMID: 23255603
    9. Blocking the expression of the thromboxane receptor significantly suppresses the prothrombotic effect of C-reactive protein. PMID: 22879580
    10. The thromboxane A(2) receptor agonist 11-deoxy PGF(2alpha) can partially alleviate embryo crowding in the Lpar3((-/-)) females and embryo crowding likely contributes to reduced litter size in the Lpar3((-/-)) females. PMID: 22222195
    11. We show here that thromboxane receptor in the striatum locally facilitates dopamine overflow. PMID: 21749493
    12. thromboxane A2 receptor signalling does not contribute critically to the pathogenesis of ischemic acute kidney injury PMID: 21449636
    13. Thromboxane A2 receptor activation via PKC-zeta-mediated NAD(P)H oxidase activation increases superoxide and peroxynitrite, resulting in eNOS uncoupling in endothelial cells. PMID: 20947827
    14. Genetic variations exist in this protein in platelet function disorders. PMID: 20162250
    15. thromboxane synthase, prostacyclin synthase and thromboxane receptor have roles in atherosclerotic lesions and correlate with plaque composition PMID: 19735918
    16. TXA2-TP signaling modulates acquired immunity by negatively regulating DC-T cell interactions. PMID: 12778172
    17. Thromboxane A2 (TXA2)-mediated platelet secretion and aggregation are important in thrombosis and the stable TXA2 analogue, U46619, induces two waves of platelet secretion, each of which precedes a distinct wave of platelet aggregation PMID: 12796499
    18. Activation of TP receptors promotes T cell proliferation, and contributes to immune-mediated tissue injury. PMID: 14662837
    19. Thromboxane A2 receptor has a role in the pathogenesis of angiotensin II-dependent hypertension. PMID: 14718360
    20. TP -/- mice have a basal increase in renal vascular resistance and filtration fraction associated with reactive oxygen species. PMID: 15213069
    21. TXA2 promotes and PGI2 prevents the initiation and progression of atherogenesis through control of platelet activation and leukocyte-endothelial cell interaction in Apolipoprotein e deficient mice. PMID: 15372102
    22. Baseline systolic blood pressure did not differ between TP(-/-) and TP(+/+) mice. PMID: 15635218
    23. Endothelial cells genetically lacking thromboxand receptor show reduced inflammatory responses when stimulated with isoprostane F2alpha-III but not other oxidized lipids. PMID: 16267259
    24. Endogenous activation of TXA2 receptor by eicosanoids did not modulate spontaneous neovascularization in the setting of ischemia. PMID: 16385086
    25. Increased responsiveness of thromboxane A(2) receptors occurs in diabetic ApoE-KO mouse kidneys. PMID: 17942572
    26. blockage of thromboxane receptors provoked embolus formation in wildtype blood PMID: 18000613
    27. 12/15LO- and TxA(2) receptor-mediated pro-atherogenic effects are two distinct pathways PMID: 18206890
    28. COX-1 contributes to the enhanced formation of both PGI(2) and TXA(2) in atherosclerosis, and to the development of the disease PMID: 18514659
    29. in L-NAME hypertension, TP receptors contribute to elevated blood pressure and cardiac hypertrophy; In this model, TP receptors also provided unexpected protection against kidney injury. PMID: 18684890
    30. Demonstrate that isoprostanes inhibit angiogenesis via activation of the TBXA2R. PMID: 18802021
    31. thromboxane receptor knockout mice showed normal pain behavior in all tests PMID: 18938093
    32. the results from the present and previous studies suggest an autocrine loop, involving cyclooxygenase-2, thromboxane A synthase, and thromboxane A2 and its receptor, in cyclooxygenase-2-dependent inhibition of StAR gene expression. PMID: 19325001
    33. Thromboxane A2 receptor stimulation impairs insulin signaling in vascular endothelial cells by selectively activating the Rho/Rho-associated kinase/LKB1/PTEN pathway. PMID: 19403525

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:21390

    STRING: 10090.ENSMUSP00000100962

    UniGene: Mm.4545