Recombinant Mouse T-lymphocyte activation antigen CD80 (Cd80)

1. CD80 regulates Th17 differentiation in Coxsackie virus B3-induced acute myocarditis. PMID: 29039143
2. The study showed an association between CD80 and bone mineral density and the risk of osteoporosis. PMID: 28466138
3. this study shows that CD80 expressed by CD8(+) T cells contributes to PD-L1-induced apoptosis of activated CD8(+) T cells PMID: 29181416
4. TNFalpha is a prominent mediator of renal CD80 induction and resultant albuminuria. PMID: 27125280
5. findings do not support a role for B7-1 in podocyte biology PMID: 27528551
6. PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells PMID: 28414296
7. PD-1 receptor has a role in interacting with programmed cell death ligands and B7-1 PMID: 28270509
8. Meningococcal capsular polysaccharide-loaded vaccine nanoparticles induce expression of CD80. PMID: 24981893
9. The genetic inactivation of B7.1/B7.2 deteriorates obesity-related liver steatosis and metabolic dysregulation, likely a result of the intrinsic absence of Tregs in these mice, rendering DKO mice a novel murine model of NASH. PMID: 24845056
10. These results indicate that B7H1/CD80 interaction augments Tcon cell proliferation, IL-2 production, and expression of PD-1, which leads to increased apoptosis PMID: 25488990
11. demonstrates that the simultaneous silencing of CD40 and CD80 genes has synergistic effects in preventing allograft rejection, and may therefore have therapeutic potential in clinical transplantation PMID: 24886282
12. data show an important role of the adaptive immune system, in particular T cell CD80/86 costimulation molecules, in the physiological regulation of bone resorption and preservation of bone mass PMID: 24807557
13. CD80 and CD86 costimulatory molecules regulate OT-II CD4(+) T lymphocyte proliferation and cytokine response in cocultures with antigen-presenting cells derived from pregnant and pseudopregnant mice PMID: 24771983
14. The need for additional immune suppression in the intestine reflects commensal microbe-driven T-cell activation through the accessory costimulation molecules ICOSL and OX40L in B7 deprived mice. PMID: 25002484
15. demonstrate that subcategorizing memory B cells on the basis of their expression of CD80 and PD-L2 PMID: 24880458
16. B7.1 and B7.2 molecules have equal ability to mediate host resistance to Mycobacterium tuberculosis. PMID: 24099792
17. Data suggest that decitabine (DAC) induces CD80 expression in EL4 cells via demethylation of CpG dinucleotide sites in the promoter of CD80 gene. PMID: 23671644
18. These studies identify CD80-Fc as an alternative and potentially more efficacious therapeutic agent for overcoming PDL1-induced immune suppression and facilitating tumor-specific immunity PMID: 23918985
19. The activation of protective CD8 T cells requires positive B7-1/B7-2 costimulation even when suppression by Tregs and in particular, Treg-intrinsic CTLA-4 is circumvented. PMID: 23744647
20. Macrophages from infected animals show increased expression of PDL2 and CD80 that was dependent from the sex of the host. PMID: 23533995
21. Microglia thus isolated show high surface expression of CD11c together with the co-stimulatory molecules CD40, CD80, and CD86 that are necessary for T-cell activation. PMID: 23439211
22. Blockade of B7-1/B7-2 in NOD.AireGW/+ mice results in fulminant, early-onset autoimmune peripheral neuropathy. PMID: 23487421
23. Although CD70 is required for dendritic cell-mediated delay of T cell tolerance induction, CD80 and CD86 are necessary for refunctionalizing the tolerized T cells in prostate tumor tissue PMID: 22798683
24. These data demonstrate, for the first time, that iTregs can acquire CD80 and CD86 from mDCs, and the acquisition of CD86 may enhance their suppressive function. PMID: 22307040
25. Mixed bone marrow chimeras demonstrated a B cell-intrinsic requirement for CD80 expression for normal T(FH) cell and PC development PMID: 22450810
26. Under influence of estrogen, expression of CD80 appears to be down-regulated during activation of B cells; that is, upon addition of 17beta-estradiol to cultured splenocytes, CD80 is down-regulated but IgG is up-regulated. PMID: 21726119
27. B7-1 interactions with programmed death-1 ligand 1 (PD-L1) may be particularly important for regulating potentially pathogenic self-reactive effector T cells. PMID: 21697456
28. B7-1 on stromal cells is a key molecule regulating IL-10 production by multifunctional Treg cells, HOZOT. PMID: 20628373
29. Mice inoculated with H22 tumor cells expressing B7-1, B7-2 and 4-1BBL developed a strong cytotoxic T lymphocyte response and long-term immunity against wild-type tumor, suggesting a synergistic effect between the B7 and 4-1BBL costimulatory pathways PMID: 20563597
30. A new immune regulation loop is revealed consisting of T cell-derived interferon-gamma, B7H1 expression by antigen-presenting cells, and B7.1 expression by regulatory T (Treg) cells in an autoimmune-like graft-versus-host disease model. PMID: 21263067
31. Peripheral regulatory T-cell maintenance critically depends on the presence of classical dendritic cells expressing CD80/86. PMID: 21267999
32. inhibition of PU.1 expression by short interfering RNA in bone marrow-derived dendritic cells resulted in marked down-regulation of CD80 and CD86 expression PMID: 21119111
33. T cell-expressed CD80, more so than CD86, plays an important role in limiting expansion of effector CD8-positive cytotoxic T lymphocytes. PMID: 21115734
34. These data reveal a requirement for B7-mediated signaling in regulating the CMV-specific CD4 T cell response and establishing host-virus equilibrium. PMID: 20980516
35. In the absence of CD80/86, CD4 T cell priming was intact but secondary responses to intranasal administration of vaccinia virus were reduced. PMID: 21040905
36. T-cell costimulation via B7 ligands CD80 and CD86 is essential for development of experimental hypertension; inhibition of this process could have therapeutic benefit in the treatment of this disease. PMID: 21126972
37. The interaction of CTLA4 and B7 inhibits T helper cell type (Th)17 differentiation in vitro and in vivo and suppresses Th17-mediated autoimmunity. Blocking the CTLA4-B7 interaction potentiates Th17 cell differentiation in vitro and in vivo. PMID: 20601598
38. These results provide evidence that signaling delivered by B7-1 and B7-2 plays a role in determining the outcome of group B streptococcal induced arthritis, likely due to the different local secretory pattern. PMID: 20114085
39. Covalently linked dimers of B7-1 mediate strong and persistent early events in T cell-antigen presenting cell interaction and T cell activation. PMID: 20065109
40. B7-1 and B7-2, but not PD-L1 and PD-L2, on IL-10-treated DC and DC-derived exosomes play a critical role in immunosuppressive functions of both DC and exosomes. PMID: 19757438
41. Direct signaling through B7-1 and B7-2 is identified as a potent regulator of IgG secretion by previously activated B cells. PMID: 19933871
42. upregulation of CD80 and loss of constitutive CD86 expression on monocytes was associated with higher severity of illness and inflammation confirming the findings in our mouse model PMID: 19672303
43. Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia. B7-1 was important for the induction of CD8+ T-cell immunity in the absence of CTLA-4. PMID: 11877291
44. Simultaneous expression of allogenic class II MHC and B7.1 (CD80) molecules in A20 B-lymphoma cell line enhances tumor immunogenicity. PMID: 11911464
45. B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo. B7-CD28 interaction enhances T-cell clonal expansion. PMID: 11929778
46. CD80 is important in mediating a down-regulatory effect on CD8+ CTL development, perhaps through preferential binding to CTLA4. PMID: 11937530
47. B7-1 in deleting pathogenic autoreactive T cells in the thymus. PMID: 11956287
48. distinct differences in the ability of LT and LT (E112K) to enhance B7-1 and B7-2 on APC, as well as a dependence upon these costimulatory molecules for their adjuvant properties PMID: 12165495
49. findings indicate that B7-1a, an alternatively spliced form of B7-1, serves as a more efficacious costimulatory molecule than B7-1 or B7-2 in the induction and maintenance of anti-tumor immune responses against a poorly immunogenic osteosarcoma cell line PMID: 12174878
50. Differential effects of iron deficiency on the expression of CD80 and CD86 co-stimulatory receptors in mitogen-treated and untreated murine spleen cells PMID: 12210763

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KEGG: mmu:12519

STRING: 10090.ENSMUSP00000097404

UniGene: Mm.89474