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  4. Recombinant Mouse Syndecan-4 (Sdc4)

Recombinant Mouse Syndecan-4 (Sdc4)

  • 货号：
    CSB-CF020891MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Sdc4
  • Uniprot No.：
  • 别名：
    Sdc4; Syndecan-4; SYND4; Ryudocan core protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-198
  • 氨基酸序列
    ESIRETEVIDPQDLLEGRYFSGALPDDEDAGGSDDFELSGSGDLDDTEEPRPFPEVIEPLVPLDNHIPENAQPGIRVPSEPKELEENEVIPKRAPSDVGDDMSNKVSMSSTAQGSNIFERTEVLAALIVGGVVGILFAVFLILLLVYRMKKKDEGSYDLGKKPIYKKAPTNEFYA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
  • 基因功能参考文献：
    1. SDC4 antagonizes the activation of RIG-I in a CYLD-mediated deubiquitination-dependent process, thereby balancing antiviral signalling to avoid deleterious effects on host cells. PMID: 27279133
    2. Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4. PMID: 27751945
    3. Syndecan-4 is essential for the compensated hypertrophy and the maintenance of cardiac function during the process of heart failure following pressure overload. PMID: 28395201
    4. This study demonstrates that the shedding of synd4 from Endothelial progenitor cells (EPCs) plays a key role in advanced glycation end products-mediated dysfunction of EPC migration and homing. PMID: 27662820
    5. Syndecan-4 therapy also induces a marked immunomodulation in the tissues, increasing the polarization of macrophages toward the M2 phenotype. PMID: 26891081
    6. SDC4 thus controls flow-induced lymphatic endothelial cell polarization via regulation of VANGL2 expression. PMID: 27789626
    7. loss of N-sulfation leads to the disruption of the pattern of distribution of Sdc-4 within the glomeruli of Ndst1-/- mutants PMID: 26936875
    8. Sdc4 has been identified as a mycobacterial attachment receptor on alveolar epithelial cells. PMID: 27279134
    9. Synd4 shedding from vascular endothelial cells played an important role in the diabetes-related impairment of angiogenesis. PMID: 27018253
    10. the present study demonstrated that synd4 was involved in the chemotactic migration of ECs in vitro and in vivo. PMID: 27541034
    11. Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice. PMID: 26449522
    12. SDC4 plays an important role in asthma induction. Disturbed SDC4 signalling leads to an impaired motility and directional migration of antigen-presenting dendritic cells. PMID: 26165408
    13. Syndecan-4 exerts a dual role in collagen cross-linking, one involving its cytosolic domain and calcineurin/nuclear factor of activated T-cells signalling leading to collagen PMID: 25587045
    14. Locally generated Sdc4 may play a role in regulating TRPC6 channels, and may contribute to glomerular pathology. PMID: 26193076
    15. Sdc4 contributes to the development of collagen induced arthritis by promoting germinal center formation and autoantibody production through its regulation of SDF-1-mediated B cell migration. PMID: 25989265
    16. binding interaction between syndesmos and syn4(cyto) was characterized as a low-affinity interaction (Kd = 62 muM) by surface plasmon resonance and nuclear magnetic resonance PMID: 26100207
    17. the crucial role of SDC-4 for neuron density, neurite length, and branches. PMID: 25757361
    18. SDC4 participates in amelogenesis, and FGF10 may modulate dental epithelial cell behaviors through the regulation of SDC4 expression. PMID: 25174688
    19. Data show that endothelial cells (ECs) from the thoracic aortas of syndecan 4 (S4-/-) mice were poorly aligned in the direction of the flow. PMID: 25404299
    20. Sdc4 is required for cell surface targeting of transglutaminase 2 and the development of kidney fibrosis in chronic kidney disease. PMID: 24357671
    21. The results indicate that syndecan-4 may play an important role in beta-cell function and that the cell-surface HS proteoglycans may be the missing link to maintaining islet longevity after isolation. PMID: 22872317
    22. Results indicate that the DC-HIL/syndecan-4 (SD-4) pathway regulates autoimmune responses by mediating the T cell suppressor function of myeloid-derived suppressor cells (MDSCs). PMID: 24516197
    23. Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways. PMID: 24235146
    24. Sdc4 has a dynamic expression pattern during development and is detected in tissues, including the neural tube during and following closure, the hindgut and the cochlea. Co-expression with Vangl2 is consistent with a possible role for Sdc4 in Wnt/PCP signaling during morphogenesis. PMID: 23760952
    25. PGE2-induced activation of angiogenesis is mediated via syndecan-4-dependent activation of PKCalpha. PMID: 23525101
    26. syndecan-4 is important for the differentiation of cardiac fibroblasts into myofibroblasts in the pressure-overloaded heart. PMID: 23178899
    27. A deletion or knockdown of the Syndecan 4 effector molecule PKCalpha led to a similar reduction in phosphorylation of Thr308 while overexpression of myristoylated PKCalpha rescued AktThr308 phosphorylation in endothelial cells lacking Syndecan 4. PMID: 22975683
    28. Alpha-actinin interaction with syndecan-4 has a role in stabilising cell-matrix adhesion. PMID: 22940199
    29. Our results demonstrate that syndecan 4 is functionally involved in endochondral ossification and that its loss impairs fracture healing, due to inhibition of compensatory mechanisms under inflammatory conditions. PMID: 23233348
    30. Arf6 is responsible for alpha5beta1-integrin recycling and thereby completes the cycle of syndecan-4-regulated integrin trafficking. PMID: 22790193
    31. SD-4, as the T-cell ligand of DC-HIL, is a potent inhibitor of allo-reactive T cells responsible for GVHD and a potentially useful target for treating this disease. PMID: 23113638
    32. Macrophages and epithelial cells treated with LPS had increased expression of syndecan-4. PMID: 22427536
    33. Reduced Syndecan-4 is associated with severe colitis in IL-10 knockout mice. PMID: 21987406
    34. Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway PMID: 22164265
    35. The proteoglycan syndecan 4 regulates transient receptor potential canonical 6 channels via RhoA/Rho-associated protein kinase signaling in glomerular permeability. PMID: 22155451
    36. Interception of the Sdc4 pathway enhances infarct expansion and hypertrophic remodelling during early infarct healing in ischaemic-reperfusion injury. PMID: 21632883
    37. Disruption of syndecan-4 or caveolin, gene disruption of RhoG in mice was found to retard closure of dermal wounds due to a migration defect of the fibroblasts and keratinocytes of RhoG null mice. PMID: 21982645
    38. inhibits T-cell activation by employing CD148 protein tyrosine phosphatase activity PMID: 21469128
    39. Syn4 plays an important role in the inflammatory response and granulation tissue formation, thereby preventing cardiac rupture and dysfunction after myocardial infarct PMID: 21493899
    40. Syn4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. PMID: 21330609
    41. A new houttuyfonate derivative can inhibit the proliferation of NIH3T3 cell and the expression of syndecan-4 protein induced by TNF-alpha in vitro. PMID: 20518314
    42. RGD-independent cell adhesion via a tissue transglutaminase 2-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 and {alpha}5{beta}1 integrin co-signaling. PMID: 20929862
    43. Loss of syndecan-4 do not organize alpha-smooth muscle actin into bundles. PMID: 20154082
    44. demonstrate the ability of syndecan-4 molecules to support cell attachment and spreading without the direct extracellular binding of integrins PMID: 20080785
    45. Syndecan4 has a role in regulation of microvascular homeostasis by carrying heparan sulfate PMID: 12074629
    46. role of syndecan-4 in focal adhesion kinase phosphorylation PMID: 12087088
    47. Syndecan-4 mRNA transcripts are expressed by reactive astrocytes in the region surrounding the necrotic brain tissue, exhibiting peak levels at day 7 after cryo-injury. PMID: 12112370
    48. enhanced syndecan-4 expression in mouse cardiac endothelial cells results in preferential augmentation of fibroblast growth factor 2 but not VEGF-A(165)-induced NO release PMID: 12543640
    49. This protein is synthesized together with syndecan 1 by mouse mammary gland epithelial cells and bears heparan sulfate chains that are apparently structurally indistinguishable. PMID: 12571251
    50. augmentation of TGF-beta function by induced syndecan-4 was suggested as a mechanism of the suppressive action of syndecan-4 against endotoxin shock PMID: 12975610

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Secreted.
  • 蛋白家族：
    Syndecan proteoglycan family
  • 组织特异性：
    Ubiquitous. Highest levels in liver, kidney and lung.
  • 数据库链接：

    KEGG: mmu:20971

    STRING: 10090.ENSMUSP00000017153

    UniGene: Mm.3815