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  4. Recombinant Mouse Syndecan-1 (Sdc1)

Recombinant Mouse Syndecan-1 (Sdc1)

  • 货号：
    CSB-CF020888MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Sdc1; Synd-1; Synd1; Syndecan-1; SYND1; CD antigen CD138
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-311
  • 氨基酸序列
    QIVAVNVPPEDQDGSGDDSDNFSGSGTGALPDTLSRQTPSTWKDVWLLTATPTAPEPTSSNTETAFTSVLPAGEKPEEGEPVLHVEAEPGFTARDKEKEVTTRPRETVQLPITQRASTVRVTTAQAAVTSHPHGGMQPGLHETSAPTAPGQPDHQPPRVEGGGTSVIKEVVEDGTANQLPAGEGSGEQDFTFETSGENTAVAAVEPGLRNQPPVDEGATGASQSLLDRKEVLGGVIAGGLVGLIFAVCLVAFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
  • 基因功能参考文献：
    1. Based on our results, we conclude that SDC1 on DC negatively regulates DC migration. PMID: 28453867
    2. findings support a key role for Sdc1 in modulating pulmonary protection by FFP after hemorrhagic shock. PMID: 28107214
    3. 2-O-sulfated domains in syndecan-1 heparan sulfate halt disease progression and promote liver repair by enhancing hepatocyte survival in acetaminophen-induced liver injury PMID: 28543100
    4. CD138 expression on fully mature Antibody secreting cells (ASCs) provides a selective survival advantage over less mature, newly minted ASCs, by enhancing pro-survival cytokine signaling. PMID: 28381397
    5. Sdc1 deficiency results in increased susceptibility to colitis-associated tumorigenesis. PMID: 28350804
    6. MMP7 shedding of syndecan-1/CXCL1 complexes functions as a checkpoint that restricts neutrophil activation at sites of epithelial injury. PMID: 26934670
    7. Data show that heparanase-1 (HPA-1) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1) facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1/VEGF-C complex into the medium of hepatocarcinoma cell. PMID: 28209511
    8. This study indicates that, while syndecan-1 is important for providing a barrier to acute S. aureus infection in PD, it does not affect peritoneal fibrosis and angiogenesis. PMID: 26832929
    9. Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1) and -beta-D-glucuronidase heparanase (HPSE). PMID: 25702768
    10. Study showed the expression, distribution and function of syndecan-1 in primary sensory neurons after nerve injury PMID: 26002314
    11. A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation. PMID: 25912030
    12. The PPARgamma agonist rosiglitazone rescues Sdc1-/- intradermal adipose tissue, placing PPARgamma downstream of Sdc1 in triggering adipocyte differentiation PMID: 25101993
    13. no expression within the vasculature PMID: 25972509
    14. Specific structural motifs in syndecan-1 HS promote Staphylococcus aureus corneal infection by inhibiting neutrophil CRAMP. PMID: 25931123
    15. These results demonstrate that defective motility in Sdc-1(-/-) macrophages promotes a persistent inflammatory state with relevance to the pathogenesis of atherosclerosis. PMID: 25550207
    16. Sdc1 affects arteriogenesis in response to hindlimb ischemia and is required in the local tissue environment for normal arteriogenesis. PMID: 25194470
    17. Syndecan-1 promotes vascular smooth muscle cell differentiation and quiescence. PMID: 24587062
    18. The conserved domain 2 (C2) and variable (V) regions of syndecan- 1 cytoplasmic tail mediate heparanase processing. PMID: 24788042
    19. These data show that CD138(+) cells, induced by treatment with CS, migrate into the bone marrow and may displace other antigen-specific plasma cells. PMID: 24555985
    20. studies support a key role for sdc-1 in endothelial mechanosensing and regulation of endothelial phenotype. PMID: 24554698
    21. In Sdc-1(-/-) mice, early leukocyte recruitment via the choroid plexus is enhanced, and IL-6 is elevated, which collectively results in higher numbers of the disease inducing Th17 cells in the CNS, thereby contributing to enhanced disease severity. PMID: 24078687
    22. high expression of the ppGalNAc-T13 gene generates tTn antigen on Syndecan 1, leading to enhanced invasion and metastasis via the formation of a complex consisting of integrin alpha5beta1, Syndecan 1, and MMP-9 in the glycolipid-enriched microdomain/rafts. PMID: 23814067
    23. Syndecan-1 does not appear to be a prerequisite for the existence of an endothelial glycocalyx. PMID: 23428342
    24. early differentiated CD138(high)MHCII(+) rather than terminally differentiated CD138(high)MHCII(low) plasma cells may be involved in the renal inflammatory injury in lupus, due to CXCR3 expression and IgG secretion. PMID: 23520491
    25. Clearance of triglyceride-rich lipoproteins by hepatic SDC1 is atheroprotective and mediated by multivalent binding to ApoE and ApoAV. PMID: 23676495
    26. These results suggest that insulin stimulates the association of insulin receptor with syndecan-1 and the complex formation of syndecan-1 and integrin could play an important role in ERK I/II-ALP signaling pathway in osteoblast cells. PMID: 23252577
    27. Sdc1 in the germinal niche is a key HSPG regulating the maintenance and proliferation of NPCs during cortical neurogenesis, in part by modulating the ability of NPCs to respond to Wnt ligands. PMID: 22936997
    28. The loss of syndecan-1 expression in the epithelial cell membrane is associated with tumor cell growth and invasiveness PMID: 22686587
    29. These results suggest that syndecan-1 may have a crucial role in the survival of injured motor neurons and in nerve regeneration after injury. PMID: 22944346
    30. Data suggest a mechanism for the inhibitory effects of Sdc-1 on cell growth that involves the interaction between the cytoplasmic domain of Sdc-1 and the SUMO-1 E3 ligase, Topors. PMID: 22912899
    31. did not see a significant reduction in reporter-gene transduction by papillomaviruses in syndecan-1 null mice PMID: 22995187
    32. the lung epithelium requires the syndecan-1 transmembrane domain to govern cell migration and is independent from its ability to control cell adhesion via the extracellular domain. PMID: 22936802
    33. The 1.5-kb upstream region of the syndecan-1 gene was sufficient to induce its expression in dental papilla, and binding of Sp3 transcription factor may play a pivotal role in this syndecan-1 induction. PMID: 22134060
    34. Reduced Syndecan-1 is associated with severe colitis in IL-10 knockout mice. PMID: 21987406
    35. These results suggest that syndecan 1 plays a novel role in the protective effects of enteral glutamine in the postischemic gut. PMID: 22706022
    36. Data show that wildtype-syndecan-1(WT-sdc1) and unshedding-syndecan-1(uS-sdc1) are successfully constructed. PMID: 22482411
    37. syndecan-1 promotes tubular survival and repair in ischemia/reperfusion injury PMID: 22237752
    38. The myocardial levels of expression of Sdc1 mRNA and protein increased significantly in myocardial infarction(MI); The expression of soluble Sdc1 in the sera of the rats in the MI group followed a similar pattern PMID: 21842422
    39. Heparan sulfate chains of syndecan-1 regulate ectodomain shedding. PMID: 22298773
    40. Molecular functions of syndecan-1 in disease.(review) PMID: 22033227
    41. Bacillus anthracis infection contribute to the formation of thrombi consisting of aggregated bacteria, vWF, shed SDC-1, fibrin, activated platelets and fibronectin. PMID: 22001909
    42. Syndecan-1 displays a protective role in aortic aneurysm formation by modulating T cell-mediated responses. PMID: 22173227
    43. Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype PMID: 21757697
    44. SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis PMID: 21257720
    45. Sdc1 shedding is activated in colitis. Heparin, which mimics Sdc1 functions, relieves colitis severity by inhibiting Sdc1 shedding and downregulating cytokines expression. PMID: 20936359
    46. previously unknown bacterial subversion mechanism where S. aureus exploits the capacity of syndecan-1 ectodomains to inhibit neutrophil-mediated bacterial killing mechanisms in an heparan sulfate-dependent manner to promote its pathogenesis in the cornea PMID: 21127056
    47. the loss of syndecan1 (sdc1) in corneal stromal cells (CSC) impacts cell migration rates, the sizes and composition of focal and fibrillar adhesions, the activation of integrins, and the assembly of fibronectin into fibrils PMID: 20580707
    48. Zoledronic acid can inhibit the growth of KM3 cells in a dose-dependent manner and inhibit CD138 expression. PMID: 19642368
    49. Sdc1 has a protective effect during experimental colitis. PMID: 20008145
    50. MMP7 shedding of syndecan-1 facilitates wound closure by causing the alpha(2)beta(1) integrin to assume a less active conformation thereby removing restrictions to migration PMID: 19668337

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Secreted. Secreted, extracellular exosome.
  • 蛋白家族：
    Syndecan proteoglycan family
  • 数据库链接：

    KEGG: mmu:20969

    STRING: 10090.ENSMUSP00000020911

    UniGene: Mm.2580