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  4. Recombinant Mouse Somatostatin receptor type 1 (Sstr1)

Recombinant Mouse Somatostatin receptor type 1 (Sstr1)

  • 货号：
    CSB-CF022724MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Sstr1; Smstr1; Somatostatin receptor type 1; SS-1-R; SS1-R; SS1R; SRIF-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-391
  • 氨基酸序列
    MFPNGTASSPSSSPSPSPGSCGEGACSRGPGSGAADGMEEPGRNASQNGTLSEGQGSAIL ISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLL RHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLG VWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAIC LCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQD DATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKS RAYSVEDFQPENLESGGVFRNGTCASRISTL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
  • 基因功能参考文献：
    1. This study showed that reduced expression of the Sstr1 which modulate antidepressant action in hippocampus. PMID: 25784603
    2. The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported. PMID: 25149275
    3. SSTR1 was expressed in Kolliker's organ on E14, on cochlear duct hair cells & supporting cells on E17 and only on the organ of Corti at birth, increasing & peaking at P14 but dropping off at P21. PMID: 22986312
    4. SSTR1-like immunoreactivity increases in hypothalamus except in paraventricular nucleus of ApoD(-/-) mice. PMID: 22581439
    5. SST and SSTRs might play an important role in regulation of neurodegeneration PMID: 21912697
    6. Data suggest an important role for the brain somatostatin receptor 1 subtype in the modulation of the gastrointestinal response to activation of brain CRF pathways. PMID: 21564422
    7. The effect of sst2 receptor knockout on sst1 receptor mRNA localization and binding sites throughout the brain has been determined. PMID: 11897118
    8. The localization of somatostatin to retinal amacrine cells, together with the expression of somatostatin receptors in amacrine, bipolar and horizontal cells suggests that somatostatin acts at multiple levels of retinal circuitry. PMID: 11988224
    9. sst1 receptor loss causes a significant increase in retinal levels of somatostatin-14 (SRIF) whereas it does not affect SRIF messenger RNA, indicating that sst1 receptors play a role in limiting retinal SRIF at the post-transcriptional level. PMID: 14614951
    10. somatostatin receptors 1 and 2 are expressed in the adult mouse kidney PMID: 15093692
    11. SSTR1 plays an important role in the regulation of insulin secretion in the endocrine pancreas in mice. PMID: 16406265
    12. SSTR1 activation can inhibit insulin secretion in pancreatic beta-cells. PMID: 18845633

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Jejunum and stomach.
  • 数据库链接：

    KEGG: mmu:20605

    STRING: 10090.ENSMUSP00000037045

    UniGene: Mm.278336