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  4. Recombinant Mouse Short transient receptor potential channel 1 (Trpc1)

Recombinant Mouse Short transient receptor potential channel 1 (Trpc1)

In Stock
  • 货号：
    CSB-CF720236MO
  • 规格：
    ￥12960
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Trpc1; Trp1; Trrp1; Short transient receptor potential channel 1; TrpC1; Transient receptor protein 1; TRP-1; mTrp1; Trp-related protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    in vitro E.coli expression system
  • 分子量：
    94.0 kDa
  • 表达区域：
    1-793aa
  • 氨基酸序列
    MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
  • 基因功能参考文献：
    1. these results suggest that dopaminergic neurotoxins initially decreased Ca(2+) entry, which inhibited the binding of NF-kappaB to the TRPC1 promoter, thereby inhibiting TRPC1 expression and resulting in cell death by preventing autophagy. PMID: 29150520
    2. the role of TRPC1 in the development of podocyte injury and disorders of the podocyte cytoskeleton, which may contribute to the development of novel therapeutics for podocyte injury-associated kidney diseases. PMID: 28949388
    3. By use of electrophysiology and intracellular Ca2+ imaging, this study characterises a Ca2+ permeable channel in white adipocytes. The current shows functional characteristics resembling the Ca2+ -permeable transient receptor potential channel 1 (TRPC1). PMID: 29524421
    4. TRPC3-induced Ca2+ entry promotes astrocyte proliferation and migration i.e. astrocyte activity in vitro which is attenuated by the presence of TRPC1. Following brain injury, the absence of TRPC3 results in a significant reduction of astrogliosis and cortical edema in vivo, suggesting that a targeted therapy to reduce TRPC3 channel activity might be beneficial in traumatic brain injury. PMID: 28636132
    5. Data show that transient receptor potential channel 1 (TRPC1) deficiency caused neuronal apoptosis in basal ganglia. PMID: 27738307
    6. TRPC1 is indispensable for the enriched environment-induced hippocampal neurogenesis and cognitive enhancement. PMID: 26910815
    7. Data (including data from studies using knockout mice) suggest that TRPC1 inhibits positive effects of exercise on insulin resistance and type II diabetes in a high-fat diet-induced obesity environment. PMID: 29074621
    8. TRPC1 regulated directly or indirectly the expression of multiple proteins, which may be crucial for the maintenance of memory ability. PMID: 27034165
    9. we confirmed that the activation of OTX2, a determinant of DA neuron development and the expression of which is induced by thyroid hormone, is dependent on TRPC1-mediated calcium signaling. PMID: 28779972
    10. These results indicate the contribution of heteromultimeric channels from TRPC1, TRPC4, and TRPC5 subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons. PMID: 28790178
    11. Down-regulation of TRPC1 in weight-bearing soleus muscles resulted in reduced muscle mass and reduced myofibre cross-sectional area. PMID: 26752511
    12. these data indicate for the first time a functional interaction between Orai1, TRPC1, and CaV1.2 channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2+) entry due to co-activation of Orai1- and TRPC1-dependent store-operated Ca(2+) channels and L-type Ca(2+) channels. PMID: 27535226
    13. mechanosensitive TRPC1 channels in murine PSCs exposed to elevated ambient pressure PMID: 27670661
    14. The results of this study showed that Loss of TRPC1 facilitated the gliotic response induced by increased intraocular pressure (IOP), suggesting that the channel might contribute to the glial mechanosusceptibility. PMID: 26985029
    15. Together the data suggests that Ca(2+) entry via the TRPC1 channels is essential for the activation of CaCC PMID: 25899321
    16. TRPC1(-/-) mice exhibited decreased survival, severe lung injury, and systemic bacterial dissemination upon infection. PMID: 26031335
    17. TRPC1 controls the activity of further Ca(2) influx channels and thus regulates the maintenance of intracellular Ca(2) gradients which are critical for cell migration. PMID: 25595528
    18. Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction. PMID: 25047165
    19. Soleus muscle TRPC1 mRNA was unaltered during the hindlimb unloading-reloading period. However, protein expression remained depressed through the reloading process. Decreased localization of TRPC1 to the sarcolemma was observed. PMID: 23852583
    20. These results suggest that the AR region of TRPC3 could mediate the heteromeric TRPC3/1 formation, and the heteromeric TRPC3/1 could participate in regulating the resting cytosolic Ca(2+) levels in skeletal muscle. PMID: 24613381
    21. TRPC1 participates in the pathophysiological development of hypoxic pulmonary hypertension in the mouse model. PMID: 24144647
    22. Data suggest that TRPC1 and TRPC4 are involved in the sprouting of sensory neurons following bladder cystitis, which leads to overactive bladder disease. PMID: 23922735
    23. Results indicate an important role of TRPC1 in pulmonary vascular remodeling underlying the development of hypoxia-induced pulmonary hypertension. PMID: 24251695
    24. promotes recovery from the anaphylactic response by repressing antigen-mediated TNF-alpha release from mast-cells PMID: 23489970
    25. propose that the positive and negative modulation of the CRAC channel by TRPC1epsilon and I-mfa, respectively, fine-tunes the dynamic range of the CRAC channel regulating osteoclastogenesis PMID: 23770672
    26. Mammalian rods express two new calcium signalling mechanisms associated with SOCE and TRPC1 signalling which modulate calcium homeostasis and may protect against prolonged [Ca2+]i decreases in saturating light PMID: 22674725
    27. Is unaltered in TRPC5 KO mice, but is abolished in TRPC1 KO and TRPC1/4 DKO mice. PMID: 23188715
    28. mGluR5 activation of cation current-carrying TRPC channels plays an important role in governing the cycle-by-cycle variability of the respiratory rhythm. PMID: 22612431
    29. TRPC1 attenuates receptor-mediated aortic contraction through activation and/or expression of smooth muscle BK(Ca) channels and participates in endothelial cell Ca(2+) influx and vasorelaxation of aorta. PMID: 23095462
    30. The suppression of TRPC1 expression arrested the adult neural progenitor cell cycle at G0/G1 phase. PMID: 22579301
    31. TRPC1 is involved in regulating Ca2+ homeostasis and inhibiting the unfoled protein rsponse and thus contributes to neuronal survival after neurotoxin exposure. PMID: 22446186
    32. the involvement of Trpc1 channels in skeletal muscle development in vitro and in vivo, and identify a Ca(2+)-dependent activation of the PI3K/Akt/mTOR/p70S6K pathway during myoblast differentiation and muscle regeneration. PMID: 22399301
    33. This study concluded that TRPC1 can be activated downstream of NMDA receptor activation and contribute to slow synaptic transmission in the olfactory bulb, including the calcium dynamics required for asynchronous release from the granule cell spine. PMID: 22539836
    34. Study concludes that mechanical injury of brain endothelial cells induces a rapid influx of calcium, mediated by TRPC1 and TRPP2 channels, which leads to NO synthesis and actin cytoskeletal rearrangement. PMID: 22192412
    35. The results suggested that TRPC1 may be important in the detection of innocuous mechanical force. PMID: 22072513
    36. report that the large depolarizing plateau potential that underlies the epileptiform burst firing induced by metabotropic glutamate receptor agonists in lateral septal neurons was completely abolished in TRPC1/4 double-knockout mice PMID: 22144671
    37. a novel regulatory mechanism relying on the expression of TRPC1 and the subsequent formation of heteromeric TRPC channel complexes with reduced calcium permeability, thereby fine-tuning neuronal migration. PMID: 22157757
    38. An enhanced vesicular trafficking of heteromeric TRPV4-C1 channels contributes to store-operated Ca(2+) entry in vascular endothelial cells. PMID: 21930300
    39. Agents that deplete intracellular Ca(2+) stores activate native heteromeric TRPC1/C5 channels in vascular smooth muscle cells. PMID: 21968068
    40. Data suggest that UCN regulates osteoclast resorption by suppressing osteoclast maturation/function via suppression of constitutively active cation channel (CRFR2beta) with properties of canonical transient receptor potential 1 (TRPC1) channel. PMID: 22083217
    41. It is suggested that different levels of the stretch-activated calcium channel protein TRPC1 may contribute to the different degrees of the dystrophic phenotype seen in mdx mice PMID: 21900691
    42. the enhanced expression of TRPC1 increases SOCE and has a negative effect on the STIM1-Orai1 system, indicating an interaction between these proteins. PMID: 21524792
    43. data demonstrate that TRPC1 acts as a negative regulator of endothelial KCa channel-dependent EDHF-type vasodilatations and thereby contributes to blood pressure regulation PMID: 20718731
    44. Klotho protein is associated with VEGFR-2/TRPC-1 in causing cointernalization, thus regulating TRPC-1-mediated Ca(2+) entry to maintain endothelial integrity. PMID: 20966350
    45. Data show that gene silencing and pharmacological inhibition of TRPC1 significantly reduced connexin 43 up-regulation and Cx43/cytoskeletal interaction elicited by sphingosine 1-phosphate. PMID: 20614160
    46. TRPC1 participates in calcium influx and other key events required for mast cell degranulation. PMID: 20571036
    47. canonical transient receptor potential 1 and canonical transient receptor potential 3 have roles in normal and asthmatic airway smooth muscle cells PMID: 19648473
    48. TRPC1 may be expressed in the plasma membrane [letter] PMID: 20097773
    49. TRPC1 ion channels modulate the entry of Ca++ during repeated contractions and help muscles to maintain their force during sustained repeated contractions. PMID: 19846750
    50. Homer facilitates a physical association between TRPC1 and the IP(3)R that is required for the TRP channel to respond to signals PMID: 14505576

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC1 sub-subfamily
  • 数据库链接：

    KEGG: mmu:22063

    STRING: 10090.ENSMUSP00000057640

    UniGene: Mm.149633