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  4. Recombinant Mouse Short-chain dehydrogenase/reductase 3 (Dhrs3)

Recombinant Mouse Short-chain dehydrogenase/reductase 3 (Dhrs3)

  • 货号：
    CSB-CF006860MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Dhrs3
  • Uniprot No.：
  • 别名：
    Dhrs3; Rsdr1; Short-chain dehydrogenase/reductase 3; Retinal short-chain dehydrogenase/reductase 1; retSDR1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-302
  • 氨基酸序列
    MVWKWLGALVVFPLQMIYLVTKAAVGMVLPPKLRDLSRESVLITGGGRGIGRHLAREFAE RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQMAKAVREKVGDITIL VNNAAVVHGKSLMDSDDDALLKSQHVNTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALS AIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPP LKPETVARRTVDAVQQNQALLLLPWTMNILIILKSILPQAALEEIHRFSGTYTCMNTFKG RT
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
  • 基因功能参考文献：
    1. Epicardial upregulation of DHRS3 gene Results in Defective Coronary Vessel Development. PMID: 29689192
    2. Yap targets Dhrs3, to reduce retinoic acid synthesis and inhibit cardiac fibroblast differentiation during development. PMID: 29689192
    3. Dhrs3 plays critical roles in the development of the heart and the coronary vasculature by controlling the formation of retinoic acid. PMID: 29447006
    4. DHRS3 is important in limiting the formation of retinoic acid to ensure the proper development of the coronary vasculature. PMID: 29447006
    5. DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. Lack of DHRS3 leads to increases in the levels of retinoic acid, decreases in the levels of retinol and retinyl esters and changes in the expression of genes regulated by retinoic acid. As a result, Dhrs3-deficient embryos exhibit defects in the development of the heart, palate and skeleton and are not viable. PMID: 24005908
    6. Reduction of retinaldehyde by DHRS3 is critical for preventing formation of excess ATRA during embryonic development. PMID: 24005908
    7. p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation. PMID: 21659514

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 组织特异性：
    In the embryo, expressed in developing osteogenic and chondrogenic tissues of vertebra, rib, tooth and limb bud.
  • 数据库链接：

    KEGG: mmu:20148

    STRING: 10090.ENSMUSP00000122552

    UniGene: Mm.14063